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Anticancer biological film nano target cooperated plastid and preparing method and application thereof

A biofilm and nanotechnology, applied in the field of biomedicine, can solve the problems of increasing the difficulty of tumor cells, increasing the toxicity of sensitizing drugs, and increasing clinical applications, achieving the effects of low cytotoxicity, increased number of atoms, and good biocompatibility.

Inactive Publication Date: 2017-11-10
广西玉林魔树树棉科技有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The problems of anticancer drugs currently used in clinical practice include: high toxicity of sensitizing drugs, poor targeting of drugs, or daily radiotherapy combined with daily medication, which increases the inconvenience of clinical application, etc.
This increases the difficulty for tumor cells to internalize silica

Method used

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  • Anticancer biological film nano target cooperated plastid and preparing method and application thereof
  • Anticancer biological film nano target cooperated plastid and preparing method and application thereof
  • Anticancer biological film nano target cooperated plastid and preparing method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] A biomembrane nano-targeting ligand body is composed of the following raw materials in parts by weight: 160 parts of lecithin, 40 parts of bovine serum albumin, 10 parts of targeting polypeptide and 5 parts of ferrous sulfate. The targeting polypeptide is a polypeptide formed by dehydration polymerization of 5 amino acids.

[0039] Its preparation method comprises the following steps:

[0040] 1) Dissolve lecithin in chloroform to make lecithin chloroform solution, and dissolve bovine serum albumin, targeting polypeptide and ferrous sulfate in water respectively to obtain protein solution, polypeptide solution and ferrous sulfate solution;

[0041] (2) Add the peptide solution and the protein solution into the lecithin chloroform solution, vortex at a speed of 1000 r / min for 20 min, and ultrasonically at 40 kHz for 10 min to obtain a suspension A;

[0042] (3) Add ferrous sulfate solution into solution A, vortex at 1000 r / min for 20 min, and ultrasonicate at 80 kHz for...

Embodiment 2

[0047] An anti-cancer biomembrane nano-targeted ligand body, which consists of the following raw materials in parts by weight: 200 parts of phospholipids, 50 parts of human serum albumin, 30 parts of targeting polypeptides, 5 parts of manganese sulfate and 10 parts of potassium ferrocyanide . The targeting polypeptide is a polypeptide composed of 13 amino acids dehydrated and polymerized.

[0048] Its preparation method comprises the following steps:

[0049] 1) Dissolve lecithin in chloroform-ethanol (2:1 volume ratio) to make lecithin chloroform-ethanol solution, dissolve human serum albumin, targeting polypeptide, manganese sulfate, and ferrous sulfate in water to obtain protein solution, polypeptide solution, manganese sulfate solution, ferrous sulfate solution;

[0050] (2) Add the polypeptide solution and protein solution to the chloroform-ethanol solution of phospholipids, vortex for 10 minutes at a rotation speed of 1500 r / min, and sonicate at 80 kHz for 20 minutes t...

Embodiment 3

[0056] An anti-cancer biofilm nano-targeted ligand body, which is composed of the following raw materials in parts by weight: 250 parts of lecithin, 60 parts of soybean albumin, 50 parts of targeting polypeptide, 3 parts of potassium ferrocyanide, and ferric chloride 4 parts of salt and 1 part of manganese sulfate. The targeting polypeptide is a polypeptide composed of 10 amino acids dehydrated and polymerized.

[0057] Its preparation method comprises the following steps:

[0058] 1) Dissolve lecithin with cyclohexane to make lecithin cyclohexane solution, dissolve soybean albumin, targeting polypeptide, potassium ferrocyanide, ferric chloride, and manganese sulfate in water respectively to obtain protein solution, Polypeptide solution, potassium ferrocyanide, ferric chloride solution, manganese sulfate solution;

[0059] (2) Add the polypeptide solution and the protein solution to the lecithin cyclohexane solution, vortex for 5 minutes at a rotation speed of 3000 r / min, an...

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Abstract

The invention discloses an anticancer biological film nano target cooperated plastid and a preparing method thereof. The cooperated plastid is prepared from, by weight, 160-250 parts of lecithin, 40-60 parts of soluble protein, 10-50 parts of target polypeptide and 5-20 parts of soluble meta salt. The prepared anticancer biological film nano target cooperated plastid is easily fused with a cell membrane, the biocompatibility, the targeting performance, the degradability, the bioavailability and the stability of drugs can be improved, the degradability is high, the anticancer biological film nano target cooperated plastid is safe and poisonous to the human body, and normal tissue cells are not damaged; the anticancer biological film nano target cooperated plastid can serve as a tumor diagnosis reagent, a carrier for of drugs for resisting cancer, a transgene carrier, a photo-thermal photodynamic therapeutic agent, an ultrasonic photodynamic therapeutic carrier, a radio frequency and microwave hyperthermia carrier, a medical image reinforcing agent and the like.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to an anti-cancer biofilm nano-targeting ligand and its preparation method and application. Background technique [0002] Cancer (Cancer) is currently one of the most common major diseases that seriously threaten people's health and life. The current drug treatment of cancer still faces many bottlenecks, such as high recurrence rate, rapid drug resistance, high toxicity and side effects, and drug treatment. low efficiency. The current problems of anticancer drugs in clinical use include: high toxicity of sensitizing drugs, poor targeting of drugs, or daily radiotherapy combined with daily medication increases the inconvenience of clinical application, etc. Taking cisplatin as an example of an anticancer drug, the drug itself has a good anticancer effect and can be used as a first-line chemotherapy drug. At the same time, cisplatin is a highly effective radiosensitiz...

Claims

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Application Information

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IPC IPC(8): A61K47/69A61K47/64A61K47/52A61K41/00A61K9/127A61K49/00A61P35/00
CPCA61K41/0033A61K41/0052A61K41/0057A61K49/0002
Inventor 聂国朝方贵定韦冬群劳艳霞黄雪芳罗小华黄惠民
Owner 广西玉林魔树树棉科技有限公司
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