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A kind of Schima superba extract and its application

A technology of extract and lotus root, applied in the field of lotus root extract, can solve the problem of no antibacterial biological activity of the lotus root extract, and achieve the effect of good antibacterial effect

Active Publication Date: 2020-12-22
河北圣奥化妆品有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the prior art, there is no relevant report on the antibacterial biological activity of Schima superba extract

Method used

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  • A kind of Schima superba extract and its application
  • A kind of Schima superba extract and its application
  • A kind of Schima superba extract and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] In vitro anti-Candida albicans activity test

[0019] In this experiment, the sensitive strains of Candida albicans and the resistant strains of Candida albicans were used as indicator bacteria, and the antibacterial activity of the extracts was determined by the Oxford cup method in vitro drug susceptibility test.

[0020] Wood lotus water extract

[0021] The root bark of the lotus root was properly pulverized, passed through a 40-mesh sieve, and 200 g was taken, and 500 mL of water was added for heating and reflux extraction for 3 times, each time for 1 hour. The extracts were combined and concentrated under reduced pressure to obtain 18.6 g of the extract.

[0022] xylohol extract

[0023] The root bark of the lotus root was properly pulverized, passed through a 40-mesh sieve, 200 g was taken, and 500 mL of 95% ethanol water was added for heating and reflux extraction for 3 times for 1 hour each time. The extracts were combined and concentrated under reduced pressu...

Embodiment 2

[0032] 4.5 kg of dried coarse powder of the stem of the lotus root was heated and refluxed 3 times with 95% ethanol (8 times the amount of medicinal materials) for 2 hours each time, and the extracts of the 3 times were combined and concentrated under reduced pressure to obtain 200 g of total extract.

[0033] The total extract was dissolved and dispersed with 50% methanol water, and extracted with petroleum ether, chloroform, ethyl acetate and n-butanol successively to obtain 50 g of petroleum ether layer, 35 g of chloroform layer, 22 g of ethyl acetate layer, and 20 g of n-butanol. and water layer 45g. The ethyl acetate fraction was subjected to silica gel column chromatography with a chloroform-methanol system (100:0; 90:10; 80:20; 70:30; 60:40; 50:50; 30:70; 0:100) to obtain Fr.1 -20 fractions. The fraction Fr.12 (3.3g) was subjected to ODS reverse column chromatography (180g, 3.5cm x 40cm) water-methanol system (80:20; 70:30; 60:40; 40:60; 20:80; 0 : 100) to obtain frac...

Embodiment 3

[0038] 1. Structural identification of the compound sasanquasaponin III (SS-9)

[0039]

[0040] white amorphous powder, (c 0.30, MeOH). Both Liebermann-Buchard and Molish reactions were positive, and concentrated sulfuric acid-vanillin showed red color (TLC), which was presumed to be triterpenoid saponins. ESI-MS m / z1241.6[M+Na] + , suggesting that the molecular weight may be 1218, combined with 1 H NMR and 13 C NMR spectrum speculates that the molecular formula of compound SS-9 is C 59 H 94 O 26 .

[0041] 1 H NMR spectrum shows 7 angle methyl hydrogen signals [δ H 0.81(3H,s,H-25),1.03(3H,s,H-26),1.08(3H,s,H-29),1.08(3H,s,H-24),1.30(3H,s, H-23), 1.43(3H,s,H-30),1.85(3H,s,H-27)], 1 alkene hydrogen signal (δ H 5.48, br.s), 4 terminal hydrogen signals [δ H 4.92(d,J=7.1Hz,H-1'),5.95(d,J=7.6Hz,H-1"),6.19(d,J=7.0Hz,H-1"') and 6.26(br. s,H-1″′)], a set of characteristic angelica acyl hydrogen signals [δ H 1.88(s,H 3 -5″″′), 2.05(d, J=6.6Hz, H 3 -4""'), 5.86 (...

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Abstract

The invention discloses applications of a Schima superba extract in preparation of antifungal drugs or health products or cosmetics, wherein the part of the Schima superba is preferably the root and / or the stem, the extract comprises a water extract or an ethanol extract, and the ethanol is preferably 95% ethanol.

Description

technical field [0001] The present invention relates to the field of medicinal materials, in particular to a lotus root extract and use thereof. Background technique [0002] Fungal infection, especially deep fungal infection and fungal drug resistance, is a major problem facing human health and one of the main causes of human disease and death. In recent years, with the widespread use of immunosuppressants, the widespread development of tumor radiotherapy and chemotherapy, especially the increasing number of AIDS patients, the incidence of fungal infections, especially deep fungal infections, has increased dramatically. Statistics show that in a tertiary hospital in my country, from 2012 to 2014, the mortality rate caused by fungal infection in the hospital reached 12.88%. Fungal infection has become one of the main causes of death in the above-mentioned immunocompromised patients with major diseases. While antifungal drugs have been widely used in the clinic for a long t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/704A61K36/82A61P31/10A61K8/9789A61K8/60A61Q17/00A61K125/00A61K135/00
CPCA61K8/602A61K8/97A61K9/0034A61K9/0053A61K31/704A61K36/82A61K2236/333A61Q17/005
Inventor 吴春李黎明王雅英
Owner 河北圣奥化妆品有限公司
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