Digestion-resistant starch as well as preparation method and applications thereof

A technology of anti-digestible starch and starch, which is applied in pharmaceutical formulations, medical preparations of non-active ingredients, food science, etc., can solve the problems of small-scale carrier materials, unfavorable large-scale production, low production efficiency, etc., and achieve improved targeting Conveying efficiency, high degree of automation and controllability, and high conversion rate

Active Publication Date: 2017-12-01
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the research on constructing drug/functional factor delivery system with starch-based carrier materials is mostly focused on how to improve the resistance of the delivery carrier to the extreme environment of the human body, but there are relatively few re

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  • Digestion-resistant starch as well as preparation method and applications thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027]Common cornstarch and phosphate buffer (pH 5.0) are formulated into starch slurry at a ratio of 5% by mass of starch. After gelatinization, put it into an enzyme membrane reactor. And the ultrafiltration membrane of the pullulanase immobilized 30ASPU / g starch carries out enzymolysis and ultrafiltration, processes 30min to obtain filtrate, adds the lauryl gallate of 5% starch dry basis mass in filtrate, 60 ℃, under 0.5MPa Mix for 30 minutes. Finally, wash with 70% ethanol and dry to obtain the product.

[0028] The digestibility of the digestible starch prepared in this example was measured by Englyst method; the antibacterial activity of starch-lauryl gallate was measured by calculating the total number of Staphylococcus aureus colonies in the culture medium; the antioxidant activity of the complex was measured by DPPH method. The control sample was common corn starch.

[0029] Measured through testing, the product anti-digestive starch content prepared in this embodim...

Embodiment 2

[0031] Potato starch and phosphate buffer solution (pH 6.0) are made into starch slurry according to the ratio of starch mass percentage of 8%. After gelatinization, put it into the enzyme membrane reactor. The ultrafiltration membrane of the pullulanase immobilized 35ASPU / g starch carries out enzymolysis and ultrafiltration, processes 50min and obtains ultrafiltration, adds ascorbyl palmitate of 10% starch dry weight in filtrate, 70 ℃, under 4.5MPa With 100min. Finally, wash with 70% ethanol and dry to obtain the product.

[0032] The digestibility of the digestible starch prepared in this example was determined by Englyst method; the antibacterial activity of starch-ascorbyl palmitate was measured by calculating the total number of Staphylococcus aureus colonies in the culture medium; the antioxidant activity of the complex was determined by DPPH method. The control sample was potato starch.

[0033] Measured through testing, the product anti-digestive starch content prepa...

Embodiment 3

[0035] Tapioca starch and phosphate buffer solution (pH 4.8) are made into starch slurry according to the ratio of starch mass percentage of 10%. After gelatinization, put it into the enzyme membrane reactor. The ultrafiltration membrane of the isoamylase immobilized 45 ASPU / g starch carries out enzymolysis and ultrafiltration, obtains filtrate after processing 110min, adds the lauryl gallate of 15% starch dry weight in filtrate, 70 ℃, under 6MPa With 80min. Finally, wash with 70% ethanol and dry to obtain the product.

[0036] The digestibility of the digestible starch prepared in this example was measured by Englyst method; the antibacterial activity of starch-lauryl gallate was measured by calculating the total number of Staphylococcus aureus colonies in the culture medium; the antioxidant activity of the complex was measured by DPPH method. The control sample was tapioca starch.

[0037] Measured through testing, the product anti-digestive starch content prepared in this...

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Abstract

The invention discloses digestion-resistant starch as well as a preparation method and applications thereof, belonging to the field of deeply processing starch. The preparation method comprises the following steps: preparing starch slurry from 5-15% of starch and a phosphate buffer solution and then gelatinizing, adding into an enzymatic membrane reactor, performing enzymolysis and ultrafiltration sequentially by utilizing ultrafiltration membranes respectively with cut-off molecular weight of 1000Da and 100000Da and immobilized pullulanase or isoamylase, wherein the vigor of the immobilized enzyme is 10-55ASPU/g starch; adding fat-soluble phenol derivatives into the cut-off filtrate, compounding under a pressure filed and then washing with ethanol, and drying to obtain a product. The digestion-resistant starch is a compound of starch and fat-soluble phenol derivatives, has digestion-resistant, anti-oxidization and bacteriostatic activity, can be used for functional active substances to control released carrier materials, and is beneficial to stability of functional factors in a delivery system.

Description

technical field [0001] The invention relates to the field of deep processing of starch, in particular to the preparation of anti-digestion starch with anti-oxidation and antibacterial functions by using enzyme-membrane reaction, and its use in the research and development of the field of controlled release of biological active substances. Background technique [0002] As the main dietary source of carbohydrates, starch provides the main source of energy for humans; at the same time, as a renewable resource second only to cellulose, starch is cheap, easy to obtain, safe, non-toxic and has good biocompatibility, and is often used as a drug And the construction of delivery vectors such as functional factors. For a long time, researchers from all over the world have attached great importance to the development and utilization of natural polysaccharides, especially the modification of starch through various modification methods and the construction of functional factor delivery s...

Claims

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Application Information

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IPC IPC(8): C12P19/16C12P19/04A61K47/36A61K47/14A61K47/22A23L29/30
CPCA61K47/14A61K47/22A61K47/36A23L29/30C12P19/04C12P19/16
Inventor 李晓玺陆萍池承灯陈玲李琳
Owner SOUTH CHINA UNIV OF TECH
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