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Nanometer hydroxyapatite dispersion body and preparation process thereof

A nano-hydroxyapatite and dispersion technology, applied in the field of nano-materials, can solve the problems of expensive surfactants, lower biological performance, and difficulty in complete removal, etc., achieve particle uniformity reduction, improve transparency, and save aging the effect of time

Active Publication Date: 2018-01-09
BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the surfactant, which plays a crucial role in controlling the uniform generation of hydroxyapatite particles, and the organic solvent necessary to establish the oil-water system of the microemulsion will bring two main problems: First, due to the nano-apatite particles It will have a strong adsorption effect on organic matter, and it is difficult to completely remove it after repeated cleanings, which reduces its biological performance and limits its application; secondly, some surfactants used to control particle size distribution are often more expensive. If it is used for large-scale commercial production of nano-hydroxyapatite dispersion, it will increase the preparation cost

Method used

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  • Nanometer hydroxyapatite dispersion body and preparation process thereof
  • Nanometer hydroxyapatite dispersion body and preparation process thereof

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Embodiment 1

[0054] The high gravity rotary packed bed reactor used in the present invention is the prior art, and the schematic diagram of the high gravity rotary packed bed reactor is as follows figure 1 As shown, the meanings represented by the numbers in the figure are: 1-calcium salt solution inlet, 2-phosphate solution inlet, 3-filler, 4-motor, 5-suspension outlet.

[0055] A method for preparing a transparent nano-zirconia liquid phase dispersion by utilizing a high-gravity rotating packed bed reactor, comprising the following steps:

[0056] 1) Dissolve 4.72g of calcium nitrate tetrahydrate in 100ml of water to prepare an aqueous solution of calcium nitrate, add 1.176g of crystal form regulator sodium citrate, adjust the pH value to 11.5 with ammonia water, and use it as raw material A.

[0057] 2) Dissolve 1.584g of diammonium hydrogen phosphate in 60ml of water to prepare an aqueous solution of diammonium hydrogen phosphate, so that the ratio of calcium to phosphorus is 1.67, and...

Embodiment 2

[0067] 1) Dissolve 11.8g of calcium nitrate tetrahydrate in 100ml of water to prepare an aqueous solution of calcium chloride, add 3.0g of crystal form regulator sodium tripolyphosphate, adjust the pH value to 10.5 with ammonia water, and use it as raw material A.

[0068] 2) Dissolve 3.96 g of disodium hydrogen phosphate in 60 ml of water to prepare an aqueous solution of disodium hydrogen phosphate so that the ratio of calcium to phosphorus is 1.67, and add ammonia water to adjust the pH value to 10.5 as raw material B.

[0069] 3) Turn on the supergravity rotation device and adjust the rotation speed to 2000rpm;

[0070] 4) Turn on the peristaltic pump, control the flow rates to 1L / min and 0.6L / min respectively, and feed the two raw materials A and B into the high-gravity rotating bed using the peristaltic pump, and keep the calcium-phosphorus ratio at 1.67 at the two feeding rates. Control the temperature of the reaction system at 60° C. to carry out the reaction.

[0071...

Embodiment 3

[0076] 1) Dissolve 2.32g of calcium chloride tetrahydrate in 100ml of water to prepare an aqueous solution of calcium nitrate, add 0.5g of crystal form regulator water glass, and adjust the pH value to 10.5 with 1mol / L sodium hydroxide as raw material A.

[0077] 2) Dissolve 0.792 g of disodium hydrogen phosphate in 60 ml of water to prepare an aqueous solution of disodium hydrogen phosphate so that the ratio of calcium to phosphorus is 1.67. Add 1 mol / L sodium hydroxide to adjust the pH value to 10.5 as raw material B.

[0078] 3) Turn on the supergravity rotation device and adjust the rotation speed to 1500rpm;

[0079] 4) Turn on the peristaltic pump, control the flow rate to be 0.2L / min and 0.12L / min respectively, and feed the two raw materials A and B into the high-gravity rotating bed by using the peristaltic pump, and keep the calcium-phosphorus ratio at 1.67 at the two feeding rates. Control the temperature of the reaction system at 25° C. to carry out the reaction.

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Abstract

The present invention discloses a nanometer hydroxyapatite dispersion body and a preparation process thereof. According to the nanometer hydroxyapatite dispersion body, nanometer hydroxyapatite particles are uniformly dispersed in a liquid phase medium, the solid content of the nanometer hydroxyapatite dispersion body is 1-5 wt%, the size of the nanometer hydroxyapatite particles is 40-60 nm, theaspect ratio of the nanometer hydroxyapatite particles is 1-5, and the liquid phase medium is water, an organic solvent, the mixture of a water-miscible organic solvent and water, or the mixture of different organic solvents. According to the present invention, by combining the hydrothermal method and the super gravity technology, the microcosmic mixing effect is strengthened, and the method has advantages of low production cost, simple operation and good repeatability; the prepared nanometer hydroxyapatite dispersion body has advantages of controlled particle size, good dispersion effect andgood stability; and with the technical scheme, the problems of easy agglomeration, poor dispersibility and the like of the nanometer hydroxyapatite particles can be solved, and the product can be endowed with the high application performance and the broad application range.

Description

technical field [0001] The invention relates to the technical field of nanometer materials. More specifically, it relates to a nano-hydroxyapatite dispersion and a preparation process thereof. Background technique [0002] Hydroxyapatite is a very important biomedical material. It is the main component of natural bone inorganic matter, and it has similar chemical composition and structure with biological hard tissue. Previous basic research and clinical applications have proved that artificially synthesized hydroxyapatite is non-toxic, non-irritating, and has no adverse reactions when implanted in the body. It has good biocompatibility and biological activity, and can not only serve as a scaffold for calcium salt deposition It can also guide the formation of new bone, and can directly form chemical bonds with human soft and hard tissues, so it has excellent osteoconductivity and can be used for clinical bone tissue repair and replacement. In addition, hydroxyapatite can a...

Claims

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Application Information

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IPC IPC(8): C01B25/32
Inventor 王洁欣吕博杨曾晓飞陈建峰张亮亮
Owner BEIJING UNIV OF CHEM TECH
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