Preparation method of electron beam radiation crosslinking composite polymer hydrogel dressing

An electron beam irradiation and composite polymer technology is applied in the field of composite polymer materials to prepare hydrogel dressings, which can solve the problems of weak irradiation cross-linking force and influence on mechanical properties, etc. Pure ingredients

Inactive Publication Date: 2018-03-13
SHANDONG LANFU HIGH ENERGY PHYSICS TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] Among the existing patent documents on electron beam irradiation technology and polysaccharide-containing hydrogel, patent CN106729960 discloses a chitosan-based hydrogel composite dressing loaded with kaempferol and its preparation method, which does not contain low molecular weight Polysaccharides, the cross-linking force of ultraviolet light irradiation is we

Method used

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  • Preparation method of electron beam radiation crosslinking composite polymer hydrogel dressing

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Weigh a certain mass of polyvinyl alcohol, polyvinylpyrrolidone, and gelatin solid powder, respectively, and add them into deionized water to make three aqueous solutions. %; respectively dissolved in a high-pressure steam container at a temperature of 120°C for 2 hours; after complete dissolution, the three solutions were mixed according to a certain volume ratio, and an appropriate amount of deionized water was added as needed to prepare a substrate layer mixed solution. The mass fraction of polyvinyl alcohol in the substrate layer mixed solution is 1 wt%, the mass fraction of polyvinylpyrrolidone is 1 wt%, and the mass fraction of gelatin is 4 wt%.

[0022] Take part of the above-mentioned substrate layer solution, add a certain amount of low-molecular chondroitin sulfate and low-molecular hyaluronic acid solid powder, and fully stir and mix. The mass fractions of low-molecular chondroitin sulfate and low-molecular hyaluronic acid are respectively 2wt%, to prepare a ...

Embodiment 2

[0026] Adopt exactly the same steps as Example 1, the only difference is the mass fraction in the mixed solution of the preparation substrate layer, the mass fraction of polyvinyl alcohol is 3wt%, the mass fraction of polyvinylpyrrolidone is 3wt%, the mass fraction of gelatin Fraction 18wt%.

[0027] The hydrogel dressing obtained by testing is sterile, and the tensile strength measured by an electronic tensile testing machine is 0.024MPa, the elongation at break is 97.45%, the ability to absorb deionized water is 17.49g / g, and the ability to absorb normal saline is 4.82g / g.

Embodiment 3

[0029] Adopt exactly the same steps as Example 1, the only difference is the mass fraction in the mixed solution of the preparation substrate layer, the mass fraction of polyvinyl alcohol is 2wt%, the mass fraction of polyvinylpyrrolidone is 2wt%, the mass fraction of gelatin Fraction 15wt%.

[0030] The hydrogel dressing obtained by testing is sterile, and the tensile strength measured by an electronic tensile testing machine is 0.026MPa, the elongation at break is 275.13%, the ability to absorb deionized water is 100.50g / g, and the ability to absorb normal saline is 9.99% g / g.

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Abstract

The invention relates to a preparation method of an electron beam radiation crosslinking composite polymer hydrogel dressing, in particular to an electron beam radiation chemical technology. The dressing consists of a substrate layer, a base material layer, a functional layer and a release film which are closely laminated in sequence, wherein the substrate layer is a hydrogel formed by mixing polyvinyl alcohol, polyvinyl pyrrolidone, gelatin and deionized water to form a settable dope which is crosslinked by electron beam radiation; the functional layer is formed by adding low-molecular chondroitin sulfate and low-molecular hyaluronic acid into the hydrogel of the substrate layer; electron beam irradiation, a pure physical means, is adopted to synchronously realize polymer crosslinking andproduct sterilization, thereby avoiding problems of preparation residues and chemical waste liquid emission of a chemical crosslinking method and a problem of pollution of ethylene oxide sterilization; and the high-cost low-molecular chondroitin sulfate and the low-molecular hyaluronic acid are only used for a thin functional layer on the surface, thereby reducing the material cost.

Description

technical field [0001] The invention relates to the technical field of preparing hydrogel dressings from composite polymer materials, in particular to electron beam radiation chemical technology. Background technique [0002] In recent years, the application of hydrogel has become increasingly widespread, and its unique advantages have also attracted attention in the field of medical cosmetology, and new products and their scope of use have continued to increase. Dry dressings represented by gauze have obvious defects, including too high permeability, which will easily dry the wound surface, adhere to the wound surface, cause mechanical damage and severe pain when replaced, and the external environment microorganisms are easy to penetrate. It accounts for a very small proportion, and the medical field in my country is also popularizing the use of moist dressings. In addition to wound isolation protection, avoiding dressing damage and pain, it can also limit the evaporation ra...

Claims

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Application Information

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IPC IPC(8): A61L15/28A61L15/26A61L15/24A61L15/32A61L15/42A61L2/08C08J3/28
CPCA61L2/087A61L15/225A61L15/26A61L15/42C08J3/28C08J2389/06C08J2429/04C08J2439/06C08L75/04C08L5/08C08L29/04C08L39/06C08L89/00
Inventor 徐宝琨杨晓煜李传南田小建王剑钢杨松山
Owner SHANDONG LANFU HIGH ENERGY PHYSICS TECH CO LTD
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