A kind of ginkgo diterpene lactone composition

A kind of ginkgo diterpene lactone and ginkgolide technology are applied in the field of ginkgo diterpene lactone composition, and can solve problems such as research on the ratio relationship of diterpene lactones

Active Publication Date: 2019-03-26
JIANGSU KANION PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This patent does not conduct in-depth research on the proportional relationship between various diterpene lactones

Method used

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  • A kind of ginkgo diterpene lactone composition
  • A kind of ginkgo diterpene lactone composition
  • A kind of ginkgo diterpene lactone composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Example 1 Protective effect of ginkgo diterpene lactone composition on ischemic brain disease model

[0025] 1. Materials

[0026] 1.1 The ginkgo diterpene lactone composition can be prepared by the following methods: get ginkgo biloba through ethanol extraction, concentration, adsorbent impurity removal, organic solvent elution, washing and purification, steps such as recrystallization, and extract parameters, adsorbent wherein Selection, eluent selection, washing solution selection and recrystallization solvent selection are adjusted to obtain; or prepared according to the method disclosed in CN1424031A, and prepared by adjusting the preparation parameters; the composition can also be prepared by compounding the compound And get. Obtain the ginkgo diterpene lactone composition of Table 1 proportioning by above-mentioned method.

[0027] Obtain different compositions or extracts by weight percentage by each method above, and measure the percentage content of its gink...

Embodiment 2

[0062] Example 2 Effect of Ginkgo Diterpene Lactone Composition on Platelet Aggregation in Rabbits

[0063] 1. Experimental materials

[0064] 1.1 Instrument

[0065] STEELIEX platelet aggregation coagulation factor analyzer, Beijing Shidi Scientific Instrument Company; LDZ5-2 centrifuge, Beijing Medical Centrifuge Factory.

[0066] 1.2 Reagents and Drugs

[0067] The specific ratio of the drug group is the same as in Table 1.

[0068] Nimodipine, produced by Shandong Xinhua Pharmaceutical Co., Ltd., batch number 1609215; adenosine diphosphate (adenosindiphosphate, ADP), Shanghai Boao Biotechnology Co., Ltd. (imported packaging); platelet activating factor (platelet activating factor, PAF), by sigma Provided by the company; trisodium citrate, Shanghai Lingfeng Chemical Reagent Co., Ltd.

[0069] 1.3 Experimental animals

[0070] New Zealand white rabbits were provided by Laifu Farm, Pukou District, Nanjing, with the experimental animal production license SCXK (Su) 2014-00...

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PUM

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Abstract

The invention relates to a ginkgo diterpene lactone composition. The extract can reduce the neurological score of rats with cerebral ischemia-reperfusion, reduce the area of ​​cerebral ischemia, reduce the water content of brain tissue after edema, increase the activity of SOD and reduce the content of MDA , and the composition can inhibit rabbit platelet aggregation induced by PAF and ADP inducers at different time points, and reduce the maximum aggregation rate. In addition, experiments have shown that each monomer compound in the ginkgo diterpene lactone composition has a certain ratio Its effect is significantly improved.

Description

technical field [0001] The invention belongs to the technical field of medicine, in particular to a fixed-component ginkgo diterpene lactone composition and its application. Background technique [0002] Ginkgo biloba has a wide range of biological activities and contains a variety of chemical components, mainly including flavonoids, terpenes, polysaccharides, phenols, organic acids, alkaloids, amino acids, steroidal compounds, trace elements, etc. Among them, vitamin C, vitamin E, carotene, calcium, phosphorus, boron, selenium and other mineral elements are also very rich, and the most important medicinal components are flavonoids and terpenes. Flavonoids and terpenoids have various effects such as blood vessel expansion and anti-oxidation. [0003] Ginkgolide, as one of the main active ingredients in Ginkgo biloba, is a rare natural compound that has not been found in other plants so far. It has anti-oxidation, anti-inflammation, anti-platelet aggregation, anti-apoptosis ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/365A61K9/00A61P9/10A61P7/02A61P25/00
CPCA61K9/0019A61K31/365A61K2300/00A61K36/16A61P25/28A61P7/02A61P9/10A61P25/00
Inventor 萧伟常秀娟周恩丽康小东王永香胡晗绯吴云王振中章晨峰
Owner JIANGSU KANION PHARMA CO LTD
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