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Hydroxyapatite-based bone tissue engineering bracket and powder 3D printing method thereof

A technology of tissue engineering scaffold and hydroxyapatite, which is applied in the field of biomedical materials, can solve the problems of affecting printing efficiency and printing accuracy, low scaffold strength, slow molding and curing, etc., and achieve fast printing speed, improved mechanical properties, and good flow sexual effect

Inactive Publication Date: 2018-05-08
JINING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the above process, in order to ensure the fluidity of the printing ink and the uniformity of each phase, the content of ceramic powder is generally low, resulting in low strength of the bracket; in addition, the molding and curing of the material is slow, which affects the final printing efficiency and printing efficiency. precision

Method used

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  • Hydroxyapatite-based bone tissue engineering bracket and powder 3D printing method thereof
  • Hydroxyapatite-based bone tissue engineering bracket and powder 3D printing method thereof
  • Hydroxyapatite-based bone tissue engineering bracket and powder 3D printing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] The powder 3D printing method of the hydroxyapatite-based bone tissue engineering scaffold has the following steps:

[0036] (1) Using CT three-dimensional imaging technology to reconstruct the health status map of the defect, combined with the defect bone state map waiting to be implanted, separate the bone morphology map to be implanted, and form a DICOM format map; convert it into STL for 3D printing through software File, further process the STL format file according to the required porosity and connectivity requirements; import the modified STL file into the 3D printer.

[0037] (2) Take a certain mass of Ca(NO 3 ) 2 , (NH 4 ) 2 HPO 4 and gelatin, were prepared as aqueous solutions; the gelatin solution was added to Ca(NO 3 ) 2 A mixed solution is formed in the solution; the pH value is adjusted to 10 with ammonia water; (NH 4 )2 HPO 4 The solution was dropped into the mixed solution for in-situ chemical co-precipitation reaction to obtain hydroxyapatite / ge...

Embodiment 2

[0040] (1) Using CT three-dimensional imaging technology to reconstruct the health status map of the defect, combined with the defect bone state map waiting to be implanted, separate the bone morphology map to be implanted, and form a DICOM format map; convert it into STL for 3D printing through software File, further process the STL format file according to the required porosity and connectivity requirements; import the modified STL file into the 3D printer.

[0041] (2) Take a certain mass of Ca(NO 3 ) 2 , (NH 4 ) 2 HPO 4 and chitosan, respectively formulated into aqueous solutions; the chitosan solution was added to the Ca(NO 3 ) 2 A mixed solution is formed in the solution; the pH value is adjusted to 10 with ammonia water; (NH 4 ) 2 HPO 4 Drop the solution into the mixed solution for in-situ chemical co-precipitation reaction to obtain hydroxyapatite / chitosan composite slurry; after the reaction, obtain hydroxyapatite / chitosan composite powder by spray drying meth...

Embodiment 3

[0044] (1) Using CT three-dimensional imaging technology to reconstruct the health status map of the defect, combined with the defect bone state map waiting to be implanted, separate the bone morphology map to be implanted, and form a DICOM format map; convert it into STL for 3D printing through software File, further process the STL format file according to the required porosity and connectivity requirements; import the modified STL file into the 3D printer.

[0045] (2) According to Ca / P atomic ratio=1.67, inorganic / organic phase ratio 60 / 40, gelatin / chitosan ratio 1 / 1, weigh a certain amount of Ca(NO 3 ) 2 , (NH 4 ) 2 HPO 4 , gelatin and chitosan were formulated into aqueous solutions respectively; the chitosan solution was added to Ca(NO 3 ) 2 The solution was mixed solution A, and the gelatin solution was added to (NH 4 ) 2 HPO 4 A mixed solution B is formed in the solution; the pH value is adjusted to 10 with ammonia water; the mixed solution B is added dropwise ...

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Abstract

The invention belongs to the technical field of biomedical materials and particularly relates to a hydroxyapatite-based bone tissue engineering bracket and a powder 3D printing method thereof. The hydroxyapatite-based bone tissue engineering bracket takes hydroxyapatite-based composite powder as a 3D printed powder material and a water-soluble polymer solution as an adhesive; the hydroxyapatite-based composite powder is one of hydroxyapatite / gelatin compound powder, hydroxyapatite / chitosan compound powder or hydroxyapatite / gelatin / chitosan compound powder obtained according to an in-situ chemical precipitation method and in combination with a spray drying process. The hydroxyapatite-based bone tissue engineering bracket provided by the invention adopts a material pore structure, is controllable in degree of connectivity, proper in mechanical property and good in biocompatibility, has good appearance size and conforms to an individualized treatment principle; the powder 3D printing method provided by the invention is high in printing speed and high in precision.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a hydroxyapatite-based bone tissue engineering scaffold and a powder 3D printing method thereof. Background technique [0002] Fractures or bone defects caused by population aging, diseases and accidents such as industrial, traffic and sports accidents amount to millions of people every year, and there is an increasing trend. In terms of the number of applications, bone transplantation has become second only to blood transfusion in human tissue transplantation. Traditional methods of treating bone defects include autologous bone, allogeneic bone and artificial bone grafting. However, these methods have problems such as insufficient donors, immune rejection, disease transmission, mismatch with the mechanical properties and formation rate of the host bone, and inability to degrade, which cannot be ignored. [0003] Tissue engineering provides a new resear...

Claims

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Application Information

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IPC IPC(8): A61L27/46A61L27/50A61L27/56B33Y10/00B33Y70/00B33Y80/00
CPCA61L27/46A61L27/50A61L27/56A61L2430/02B33Y10/00B33Y70/00B33Y80/00C08L5/08C08L89/00
Inventor 卢志华马育栋王伟娜
Owner JINING UNIV
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