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Momordica grosvenori root bionic extracts and preparation and application thereof

A technology of bionic extraction and Luo Han Guo, which is applied in the direction of drug combination, plant raw materials, medical preparations containing active ingredients, etc., can solve the problems of unconsidered development and utilization, and achieve non-toxic side effects, simple formula, and obvious blood lipid-lowering effect Effect

Inactive Publication Date: 2018-06-15
GUANGXI UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the past, people's research on the development of Luo Han Guo was limited to the extraction, separation and application of its fruit, without considering the development and utilization of its root.

Method used

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  • Momordica grosvenori root bionic extracts and preparation and application thereof
  • Momordica grosvenori root bionic extracts and preparation and application thereof
  • Momordica grosvenori root bionic extracts and preparation and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] The preparation of embodiment 1 Momordica grosvenori biomimetic extract

[0029] Follow the steps below:

[0030] (1) drying and pulverizing the roots of Luo Han Guo, and passing through a 100-mesh sieve to obtain the root powder of Luo Han Guo;

[0031] (2) Preparation of bionic extract: 0.2% sodium chloride, 0.32% pepsin and 0.02mol / L hydrochloric acid, adjust pH=5.5;

[0032] (3) Mix according to the weight ratio of Luo Han Guo root and biomimetic extract 1:30, heat in a water bath at 37°C, seal with a plastic film, extract with magnets for 120 minutes, filter, collect the filtrate, concentrate in a water bath to 1 / 4 volume, and collect the concentrate;

[0033] (4) Mix the concentrated solution in step (3) with ethyl acetate-butyl acetate solution in a volume ratio of 1:4, extract 3 times, collect the organic phase, remove the solvent by rotary evaporation under reduced pressure, and obtain a white powder, which is Monk Fruit Root Biomimetic Extract.

Embodiment 2

[0034] Example 2 The biomimetic extract of Luo Han Guo root is used to prepare blood lipid-lowering medicines

[0035] Add an appropriate amount of maltodextrin to the biomimetic extract of Luo Han Guo root prepared in Example 1, mix, add 90% ethanol, prepare a soft material, continue to make granules, dry, granulate, add magnesium stearate, silicon dioxide and Microcrystalline cellulose, mixed, compressed into tablets, made into Luo Han Guo root slices.

Embodiment 3

[0036] Embodiment 3 a kind of hypolipidemic tablet

[0037] Composition of raw materials: 20 parts of Luo Han Guo root bionic extract, 15 parts of snow ginseng, 15 parts of Cordyceps militaris, 10 parts of purslane, 10 parts of bellflower, 5 parts of buckwheat, 20 parts of auxiliary materials;

[0038] Preparation steps:

[0039] (1) Grind snow ginseng, cordyceps militaris, purslane, platycodon grandiflorum, and buckwheat, add water with a weight ratio of 1:8, soak for 1 hour, decoct for 3 hours, filter, then add filter residue with water with a weight ratio of 1:5, and fry Boil for 2 hours, concentrate to a density of 0.9-1.5, add maltodextrin, and spray dry to obtain spray powder;

[0040] (2) Add the biomimetic extract of Luo Han Guo root, magnesium stearate, silicon dioxide and microcrystalline cellulose to the spray powder prepared in step (1), mix and compress into tablets to make blood lipid-lowering tablets.

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Abstract

The invention provides momordica grosvenori root bionic extracts and a preparation method and application thereof. The preparation method comprises the steps of drying and pulverizing the roots of momordica grosvenori to obtain the root powder of the momordica grosvenori; mixing with bionic extract liquid, extracting, filtering, concentrating, and collecting concentrated solution; mixing the concentrated solution with ethyl acetate-butyl acetate solution, extracting, and removing solvent by rotary evaporation to obtain white powder which is the bionic extracts of the momordica grosvenori roots. The momordica grosvenori root bionic extracts, stachyodes lindl, cordyceps militaris, purslane, platycodon grandiflorum, buckwheat and auxiliary materials are taken to prepare descendens blood fat drugs. The momordica grosvenori root bionic extracts have an obvious effect of lowering blood fat.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine extraction technology and application, in particular to the biomimetic extract of Luo Han Guo root and its preparation, and in particular to the application of the extract in reducing blood fat. Background technique [0002] Hyperlipidemia refers to a systemic abnormal lipid metabolism disease in which total cholesterol (TC), triglyceride (TG) and low-density lipoprotein (LDL) in serum are too high or serum high-density lipoprotein (HDL) is too low. It is the direct cause of arteriosclerosis, hypertension, coronary heart disease and other diseases, and is called the "fuse" of cardiovascular and cerebrovascular diseases. At present, there are many kinds of blood lipid-lowering drugs and health foods on the market, but the drugs have many toxic and side effects on the human body, and the effect of health foods on lowering blood fat is not obvious. Therefore, it is urgent to develop a trad...

Claims

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Application Information

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IPC IPC(8): A61K36/42A61K36/70A61P3/06A61K125/00
CPCA61K36/42A61K36/068A61K36/185A61K36/346A61K36/48A61K36/70A61K2236/15A61K2236/19A61K2236/333A61K2236/55A61K2300/00
Inventor 赵立春扈芷怡
Owner GUANGXI UNIV OF CHINESE MEDICINE
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