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Triamcinolone acetonide acetate and miconazole nitrate neomycin sulfate cream and preparation method thereof

The technology of Quimixin and cream, applied in the field of Quimixin cream and its preparation, can solve the problems of uneven distribution of main drug components, easy instability of the cream, loss of effectiveness of the cream, etc. Improved penetration and reduced stinging effect

Inactive Publication Date: 2018-06-22
重庆希尔安药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] There are the following problems in the new emulsifiable paste of the prior art: 1, the absorption rate is low, causes waste for raw material medicine, 2, because this emulsifiable paste is formed by water phase, oily phase and emulsifier, emulsifiable paste is easy to leave after long-term placement Unstable, easy to cause the cream to lose its effectiveness due to oil-water separation; the main ingredient is unevenly distributed in the cream, making the efficacy unstable

Method used

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  • Triamcinolone acetonide acetate and miconazole nitrate neomycin sulfate cream and preparation method thereof
  • Triamcinolone acetonide acetate and miconazole nitrate neomycin sulfate cream and preparation method thereof
  • Triamcinolone acetonide acetate and miconazole nitrate neomycin sulfate cream and preparation method thereof

Examples

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preparation example Construction

[0036] The present invention also provides a kind of preparation method of above-mentioned trimides new emulsifiable cream, it comprises:

[0037] S1. Mix the water-based auxiliary material with the first water at 75-85°C and keep it warm for 25-45min to obtain the water phase. Make each substance in the water-based auxiliary material fully mixed with the first water.

[0038] It is preferably mixed in a water phase tank, and the operation is simple and convenient.

[0039] Preferably, the water-based auxiliary material is mixed with 120-125 parts by weight of water at 130-170 r / min for 2.5-3.5 hours; further, each substance in the water-based auxiliary material is fully mixed with the first water.

[0040] S2. Mix the oil-based auxiliary materials at 75-85°C and keep warm for 25-45min to obtain the oil phase. Make the various substances in the oil-based excipients fully mixed.

[0041] Specifically, add the oil-based auxiliary material into the oil phase tank and heat to p...

Embodiment 1

[0053] A new emulsifiable paste, which is made by the following method:

[0054] S1. Mix the water-based auxiliary material with the first water, raise the temperature to 85°C, mix for 2.5 hours under the condition of 160r / min, and keep it warm for 45 minutes to obtain the water phase.

[0055] Among them, the water-based excipients include polysorbate, sorbic acid, propylene glycol, pingpingjia, and a mixture of glyceryl stearate and polyethylene glycol stearate in a weight ratio of 5:0.6:19:2:3.

[0056] S2. Add the oil-based auxiliary materials into the oil phase tank, heat, and after part of the oil-based auxiliary materials melt, start the stirring device and mix for 2.5 hours under the conditions of 85°C and 155r / min, and keep warm for 40 minutes to obtain the oil phase.

[0057] The oil-based excipients include liquid paraffin, stearic acid, sorbitan monostearate, cetyl alcohol, stearyl alcohol and isopropyl palmitate in a weight ratio of 5:3:3:6:7:7.

[0058] S3. Firs...

Embodiment 2

[0063] A new emulsifiable paste, which is made by the following method:

[0064] S1. Mix the water-based auxiliary material with the first water, raise the temperature to 75°C, mix for 3.5 hours under the condition of 150r / min, keep it warm for 30 minutes, and obtain the water phase.

[0065] Among them, the water-based excipients include polysorbate, sorbic acid, propylene glycol, pingpingjia, glyceryl stearate and polyethylene glycol stearate with a weight ratio of 6:0.7:19:2.5:2:0.5:0.015. mixture, sodium hydroxide and disodium edetate.

[0066] S2. Add the oil-based auxiliary materials into the oil phase tank, heat, and after part of the oil-based auxiliary materials melt, start the stirring device and mix at 80°C and 155r / min for 3 hours, then keep warm for 35 minutes to obtain the oil phase.

[0067] The oil-based excipients include liquid paraffin, stearic acid, sorbitan monostearate, cetyl alcohol, stearyl alcohol and isopropyl palmitate in a weight ratio of 4:2.5:4:6...

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Abstract

The invention provides triamcinolone acetonide acetate and miconazole nitrate neomycin sulfate cream and a preparation method of the triamcinolone acetonide acetate and miconazole nitrate neomycin sulfate cream, relating to the field of medicines. The triamcinolone acetonide acetate and miconazole nitrate neomycin sulfate cream is prepared from the following raw materials in parts by weight: 0.15-0.35 part of triamcinolone acetonide acetate, 1.5-3 parts of miconazole nitrate, 0.5-1.4 parts of neomycin sulfate, 16.5-36 parts of a water-based auxiliary material, 25-38 parts of an oil-based auxiliary material, 7-9 parts of dimethyl sulfoxide, 0.15-0.3 part of sodium pyrosulfite, and 127-128 parts of water. The triamcinolone acetonide acetate and miconazole nitrate neomycin sulfate cream is high in stability, the distribution of the main medicine ingredients in the cream is uniform, the quality is stable, the skin penetrability is improved, and the effects of resisting inflammation and irritability and relieving itching are rapid. For the preparation method of the triamcinolone acetonide acetate and miconazole nitrate neomycin sulfate cream, the process is simple and easy to control, and the triamcinolone acetonide acetate and miconazole nitrate neomycin sulfate cream is suitable for industrial application.

Description

technical field [0001] The invention relates to the field of medicine, and in particular to a trimide cream and a preparation method thereof. Background technique [0002] Trimetine is a kind of dermatological medicine, which has significant curative effect on eczema, contact dermatitis, seborrheic dermatitis, neurodermatitis, tinea corporis, jock itch and tinea manus and pedis. The common dosage form of trimezin is cream, which contains miconazole nitrate as a broad-spectrum antifungal drug, and also has antibacterial effect on some Gram-positive bacteria; triamcinolone acetonide acetate is a glucocorticoid drug, which has anti Inflammatory, anti-allergic and antipruritic effects; neomycin sulfate is effective against a variety of Gram-positive and negative bacteria. [0003] There are the following problems in the new emulsifiable paste of the prior art: 1, the absorption rate is low, causes waste for raw material medicine, 2, because this emulsifiable paste is formed by ...

Claims

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Application Information

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IPC IPC(8): A61K31/58A61K31/4174A61K31/7036A61K31/10A61K9/06A61K47/02A61K47/20A61K47/12A61K47/10A61K47/14A61K47/26A61K47/18A61K47/06A61K47/32A61P31/04A61P17/04A61P29/00A61P37/08A61P31/10
CPCA61K31/58A61K9/0014A61K9/06A61K31/10A61K31/4174A61K31/7036A61K47/02A61K47/10A61K47/12A61K47/14A61K47/183A61K47/20A61K47/26A61K47/32A61K47/44A61K2300/00
Inventor 李林霞袁开超朱锋罗磊唐攀陈波梅勇王凤左娟
Owner 重庆希尔安药业有限公司
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