Triamcinolone acetonide acetate and miconazole nitrate neomycin sulfate cream and preparation method thereof

The technology of Quimixin and cream, applied in the field of Quimixin cream and its preparation, can solve the problems of uneven distribution of main drug components, easy instability of the cream, loss of effectiveness of the cream, etc. Improved penetration and reduced stinging effect

Inactive Publication Date: 2018-06-22
重庆希尔安药业有限公司
View PDF1 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] There are the following problems in the new emulsifiable paste of the prior art: 1, the absorption rate is low, causes waste for raw material medicine, 2, because this emulsifiable paste is formed by water phase, oily phase and emulsif

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Triamcinolone acetonide acetate and miconazole nitrate neomycin sulfate cream and preparation method thereof
  • Triamcinolone acetonide acetate and miconazole nitrate neomycin sulfate cream and preparation method thereof
  • Triamcinolone acetonide acetate and miconazole nitrate neomycin sulfate cream and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0036] The present invention also provides a preparation method of the above-mentioned Trimixin cream, which comprises:

[0037] S1. Mix the water-based auxiliary material with the first water at 75-85°C and keep it for 25-45 minutes to obtain the water phase. Mix the substances in the water-based auxiliary material with the first water thoroughly.

[0038] It is preferably mixed in the water phase tank, and the operation is simple and convenient.

[0039] Preferably, the water-based auxiliary material is mixed with 120-125 parts by weight of water at 130-170 r / min for 2.5-3.5 h; further, each substance in the water-based auxiliary material is fully mixed with the first water.

[0040] S2. Mix the oil-based auxiliary materials at 75-85°C and keep for 25-45 minutes to obtain the oil phase. Mix the substances in the oil-based auxiliary materials thoroughly.

[0041] Specifically, the oil-based auxiliary material is added into the oil phase tank, heated to partially melt the oil-based au...

Example Embodiment

[0052] Example 1

[0053] A new trimi cream, which is prepared by the following method:

[0054] S1. Mix the water-based auxiliary material with the first water, heat up to 85°C, mix for 2.5h under the condition of 160r / min, and keep the temperature for 45min to obtain the water phase.

[0055] Among them, the water-based adjuvants include polysorbate, sorbic acid, propylene glycol, Pingjia and a mixture of glyceryl stearate and polyethylene glycol stearate in a weight ratio of 5:0.6:19:2:3.

[0056] S2. Put the oil-based auxiliary material into the oil phase tank, heat, and after part of the oil-based auxiliary material melts, start the stirring device and mix for 2.5 hours at 85°C and 155r / min, then keep it for 40 minutes to obtain the oil phase.

[0057] The oil-based auxiliary materials include liquid paraffin, stearic acid, sorbitan monostearate, cetyl alcohol, stearyl alcohol and isopropyl palmitate in a weight ratio of 5:3:3:6:7:7.

[0058] S3. After mixing triamcinolone acetonide...

Example Embodiment

[0062] Example 2

[0063] A new trimi cream, which is prepared by the following method:

[0064] S1. Mix the water-based auxiliary material with the first water, raise the temperature to 75°C, mix for 3.5h under the condition of 150r / min, and keep the temperature for 30min to obtain the water phase.

[0065] Among them, the water-based auxiliary materials include polysorbate, sorbic acid, propylene glycol, Pingjia, glyceryl stearate and polyethylene glycol stearate with a weight ratio of 6:0.7:19:2.5:2:0.5:0.015. A mixture of sodium hydroxide and disodium edetate.

[0066] S2. Put the oil-based auxiliary material into the oil phase tank, heat, and after some of the oil-based auxiliary material melts, start the stirring device and mix for 3 hours at 80°C and 155r / min, then keep it for 35 minutes to obtain the oil phase.

[0067] Oil-based auxiliary materials include liquid paraffin, stearic acid, sorbitan monostearate, cetyl alcohol, stearyl alcohol, and isopropyl palmitate in a weight ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
Particle sizeaaaaaaaaaa
Login to view more

Abstract

The invention provides triamcinolone acetonide acetate and miconazole nitrate neomycin sulfate cream and a preparation method of the triamcinolone acetonide acetate and miconazole nitrate neomycin sulfate cream, relating to the field of medicines. The triamcinolone acetonide acetate and miconazole nitrate neomycin sulfate cream is prepared from the following raw materials in parts by weight: 0.15-0.35 part of triamcinolone acetonide acetate, 1.5-3 parts of miconazole nitrate, 0.5-1.4 parts of neomycin sulfate, 16.5-36 parts of a water-based auxiliary material, 25-38 parts of an oil-based auxiliary material, 7-9 parts of dimethyl sulfoxide, 0.15-0.3 part of sodium pyrosulfite, and 127-128 parts of water. The triamcinolone acetonide acetate and miconazole nitrate neomycin sulfate cream is high in stability, the distribution of the main medicine ingredients in the cream is uniform, the quality is stable, the skin penetrability is improved, and the effects of resisting inflammation and irritability and relieving itching are rapid. For the preparation method of the triamcinolone acetonide acetate and miconazole nitrate neomycin sulfate cream, the process is simple and easy to control, and the triamcinolone acetonide acetate and miconazole nitrate neomycin sulfate cream is suitable for industrial application.

Description

technical field [0001] The invention relates to the field of medicine, and in particular to a trimide cream and a preparation method thereof. Background technique [0002] Trimetine is a kind of dermatological medicine, which has significant curative effect on eczema, contact dermatitis, seborrheic dermatitis, neurodermatitis, tinea corporis, jock itch and tinea manus and pedis. The common dosage form of trimezin is cream, which contains miconazole nitrate as a broad-spectrum antifungal drug, and also has antibacterial effect on some Gram-positive bacteria; triamcinolone acetonide acetate is a glucocorticoid drug, which has anti Inflammatory, anti-allergic and antipruritic effects; neomycin sulfate is effective against a variety of Gram-positive and negative bacteria. [0003] There are the following problems in the new emulsifiable paste of the prior art: 1, the absorption rate is low, causes waste for raw material medicine, 2, because this emulsifiable paste is formed by ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K31/58A61K31/4174A61K31/7036A61K31/10A61K9/06A61K47/02A61K47/20A61K47/12A61K47/10A61K47/14A61K47/26A61K47/18A61K47/06A61K47/32A61P31/04A61P17/04A61P29/00A61P37/08A61P31/10
CPCA61K31/58A61K9/0014A61K9/06A61K31/10A61K31/4174A61K31/7036A61K47/02A61K47/10A61K47/12A61K47/14A61K47/183A61K47/20A61K47/26A61K47/32A61K47/44A61K2300/00
Inventor 李林霞袁开超朱锋罗磊唐攀陈波梅勇王凤左娟
Owner 重庆希尔安药业有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap