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Rhizoma-iridis-tectori orally taken solution for treating necrotic enteritis of chicken and preparation method thereof

A technique for Chuanshegan oral liquid and chicken necrotizing enteritis, which is applied to the Chuanshegan oral liquid for treating chicken necrotizing enteritis and the preparation field thereof, can solve the problems of serious drug residues, virus resistance, non-conformity and the like, and achieves a high cure rate , High extraction rate, ensure the effect of dissolution

Inactive Publication Date: 2018-07-10
SHANDONG JINZHUJI PHARM CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

And in the prior art, a large number of western medicines such as antibiotics are used, and the drug residues are serious, and it is easy to cause drug resistance of viruses, etc., which does not meet the standards of modern green food production.

Method used

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  • Rhizoma-iridis-tectori orally taken solution for treating necrotic enteritis of chicken and preparation method thereof
  • Rhizoma-iridis-tectori orally taken solution for treating necrotic enteritis of chicken and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] (1) Crush 500g of Chuanshe dried medicinal materials, add water according to the solid-to-liquid ratio of 1:40, stir evenly, and adjust the pH value to 4.0. Based on the quality of Chuanshe dry powder, add 5.0% cellulase, 2% amylase, 1.0 % protease, 1.0% pectinase, hydrolyzed at 35°C for 4 hours. Heat the reaction system to 80-100°C and cook for 50 minutes, then lower to room temperature, add ethanol to a final concentration of 80%, extract twice, the first time is 2 hours, the second time is 1.5 hours, and the two filtrates are combined. Recover ethanol until it has no alcohol smell, and then concentrate to a relative density of about 1.02. Detected by ultra-high performance liquid chromatography, the active ingredients in the extract include sheganoside, irisinin, iris flavin A, iris flavin B, and iris flavin, among which the content of shegan glucoside is 40.73%;

[0028] (2) After pulverizing 500g ferulae, first soak it in 5L saponin water for 5 hours, then add 25L...

Embodiment 2

[0031] (1) Crush 500g of Chuanshegan medicinal materials, add water according to the solid-to-liquid ratio of 1:20, stir evenly, and adjust the pH value to 6.0. Based on the quality of Chuanshe dry powder, add 5.0% cellulase, 2% amylase, 1.0% protease, 1.0% pectinase, and enzymatically hydrolyze at 45°C for 5 hours. The temperature of the reaction system was raised to 80-100° C. and cooked for 50 minutes, and then lowered to normal temperature. Add ethanol to a final concentration of 80%, extract twice, the first time for 2 hours, the second time for 1.5 hours, and combine the two filtrates. Recover ethanol until it has no alcohol smell, and then concentrate to a relative density of about 1.02. Detected by ultra-high performance liquid chromatography, the active ingredients in the extract include sheganoside, irisinin, iris flavin A, iris flavin B, and iris flavin, the content of which is 51.22%;

[0032] (2) After pulverizing 500g ferulae, first soak it in 5L saponin water ...

Embodiment 3

[0035] (1) Crush 500g of Chuanshegan medicinal materials, add water according to the solid-to-liquid ratio of 1:10, stir evenly, and adjust the pH value to 7.0. Based on the quality of Chuanshe dry powder, add 5.0% cellulase, 2% amylase, 1.0% protease, 1.0% pectinase, and enzymatically hydrolyze at 50°C for 4 hours. The temperature of the reaction system was raised to 80-100° C. and cooked for 50 minutes, and then lowered to normal temperature. Add ethanol to a final concentration of 80%, extract twice, the first time for 2 hours, the second time for 1.5 hours, and combine the two filtrates. Recover ethanol until it has no alcohol smell, and then concentrate to a relative density of about 1.02. Detected by ultra-high performance liquid chromatography, the active ingredients in the extract include sheganoside, irisinin, iris flavin A, iris flavin B, and iris xanthin, of which the content of shegan glucoside is 42.71%.

[0036] (2) After pulverizing 500g ferulae, first soak it...

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Abstract

The invention belongs to the technical field of veterinary drugs, and particularly relates to a rhizoma-iridis-tectori orally taken solution for treating the necrotic enteritis of a chicken and a preparation method thereof. The rhizoma-iridis-tectori orally taken solution is prepared from the following raw materials in parts by weight: 3 to 5 parts of rhizoma iridis tectori extract, 1 to 1.5 partsof resina ferulae extract, 0.05 to 0.08 part of potassium sorbate and 0.03 to 0.05 part of sodium hydrogen sulfite. The orally taken solution prepared by the preparation method is high in cure rate,is safe and green, can be used for improving the immunity of livestock and poultry, and further, is small in residual quantity of a drug; the synergistic effect is realized among effective components.The preparation method is used for improving the contents and categories of the active components in rhizoma iridis tectori through the manner of biological enzyme extraction, can be used for effectively utilizing a wild resource, and is a green way for developing a traditional Chinese medicinal material, and an extraction method of resina ferulae, which is provided by the invention, is high in extraction rate, and is used for furthest ensuring the dissolution of the effective components.

Description

technical field [0001] The invention belongs to the technical field of veterinary medicine, and in particular relates to a Chuanshegan oral liquid for treating chicken necrotic enteritis and a preparation method thereof. Background technique [0002] Necrotic enteritis, also known as enterotoxemia, is an acute infectious disease caused by Clostridium welchii. The main manifestations are that the sick chickens discharge black feces sometimes mixed with blood, and the intestines are inflated. The dead chickens are characterized by necrosis of the posterior small intestine mucosa. The disease often occurs suddenly, and sick chickens often die suddenly without obvious symptoms, which is more harmful to production. Clinically, amoxicillin, penicillin, tylosin, kanamycin, gentamicin and other treatments are often used. However, from the perspective of bacterial drug resistance and food safety, the development of a safe and residue-free Chinese veterinary drug will have broad app...

Claims

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Application Information

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IPC IPC(8): A61K36/88A61K9/08A61P37/04A61P31/04
CPCA61K9/0095A61K36/23A61K36/88A61K47/12A61K2236/19A61K2300/00
Inventor 李有志侯云峰刘少宁冯涛朱俊平聂婧薛梅杨婷袁爱娟
Owner SHANDONG JINZHUJI PHARM CO LTD
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