Two-photon fluorescent probe for detecting activity of pneumonia marker and synthesis method
A two-photon fluorescence and probe technology, used in fluorescence/phosphorescence, chemical instruments and methods, luminescent materials, etc., can solve the problems of lack of probes and few probes, and achieve low cytotoxicity and high yield. , the effect of easy purification
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[0052] Example: Synthesis of Fluorescent Probes
[0053] Dissolve raw material a in 5 mL of dichloromethane, then add 2 mL of thionyl chloride, and react at room temperature for 2 h. After the reaction was complete, the solvent was removed by rotary evaporation. Then petroleum ether: dichloromethane = 5:1, recrystallized to precipitate a beige solid, that is, compound b (82%).
[0054] Take compound b and compound c (the molar ratio of compound b and compound c is 1:1), dissolve in 10 mL of acetic acid, and heat at reflux at 90° C. for 5 h. After the reaction was complete, the solvent was removed by rotary evaporation. Redissolved in dichloromethane and separated through a silica gel column (eluent: ethyl acetate) to obtain an off-white solid, ie ASPC (42%).
[0055] NMR and mass spectrometry characterization:
[0056] 1 HNMR(400MHz,DMSO)2.41(s,3H),2.59-2.63(m,2H),2.65-2.80(m,2H),3.76-3.79(m,1H),5.11(s,2H),6.28(s ,1H),7.30-7.35(m,5H),7.55(d,J=12HZ,1H),7.71(d,J=12HZ, 1H),...
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