Lyotropic liquid crystal gel nano-preparation of cytokine class wound repair drug and preparation method thereof

Abstract

The invention discloses a lyotropic liquid crystal gel nano-preparation of a cytokine wound repair drug and a preparation method thereof, which is prepared from the following raw materials in mass percentage: cytokine wound repair drug 2×10 ‑7 ~8×10 ‑7 %, 35-50% of phospholipids, 30-40% of glycerides, 10-15% of solubilizers, and the balance is water; the lyotropic liquid crystal gel nano-preparations of cytokine class wound repair drugs of the present invention are selected from natural sources The material is non-immunogenic and has good biocompatibility, which can increase the stability of cytokine wound repair drugs in the preparation, effectively protect the activity of the drug, and enhance the curative effect of the drug. Proportioning to prepare nanogel preparations with different drug release rates, its good mucoadhesiveness can effectively resist external stimuli, avoid bacterial infection, moisten the wound site, accelerate the healing process, and the administration is convenient and safe.

Description

technical field [0001] The invention relates to the field of drug lyotropic liquid crystal gel preparations, in particular to a cytokine-like wound repair drug lyotropic liquid crystal gel nano preparation and a preparation method thereof. Background technique [0002] Wound repair has always been a research hotspot in the medical field. As the largest and most external organ of the human body, the skin is extremely vulnerable to trauma. In recent years, with the continuous development of industrial technology, the number of various acute trauma injuries has continued to increase. The number of chronic refractory wounds caused by irradiation has also increased accordingly. According to statistics, about 1.1 million people in the United States suffer from acute trauma every year, and about 300,000 people are hospitalized. However, the current level and quality of wound repair often cannot meet the needs of patients. Therefore, further understanding of the mechanism of wound ...

AI Technical Summary

Problems solved by technology

Most of the cytokine lyotropic liquid crystal gel preparations currently on the market for wound repair are gels and liquid lyotropic liquid crystal gel preparations, such as recombinant bovine basic fibroblast growth factor gel (trade name: Beifuxin ), recombinant bovine basic fibroblast growth factor solution for external use (trade name: Beifuji), recombinant bovine basic fibroblast growth factor eye drops (trade name: Beifushu), recombinant human epidermal growth factor gel (trade name: Yifu), recombinant human epidermal growth factor spray (trade name: Jinyin peptide), recombinant human epidermal growth factor eye drops (trade name: Yibei), but commercially available gel It is easy to cause wound pain and indirect bacterial infection, and the patient's compliance is not good, while the liquid lysotropic liquid crystal gel preparation is volatile and difficult to form a drug film on the wound surface, resulting in short-term drug efficacy

Moreover, cell growth factors are sensitive to temperature, unstable in aqueous solution, and prone to degradation and loss of activity, so their aqueous solution must be preserved at low temperature.

Images