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Ginseng glycopeptide injection pharmaceutical composition as well as preparation method and application thereof

A technology of injection and composition, applied in the field of medicine, can solve the problems of patients with cold sweat, general weakness, lack of ginseng glycopeptide hypoglycemic drugs, slow application research, etc., achieves broad market prospects and commercial value, and is suitable for a wide range of people. , the effect of less adverse reactions

Inactive Publication Date: 2018-08-24
JILIN BAINIAN HANKE PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the medicines used to treat hyperglycemia and diabetes are mainly Western medicines for hypoglycemic drugs and insulin injections, while traditional Chinese medicines are used less for hypoglycemics. Western medicines mainly include sulfonylureas and non-sulfonylureas, metformin, and α-glucosides. Oral hypoglycemic drugs such as enzyme inhibitors, thiazolidinedione derivatives, and DPP-4 enzyme inhibitors. In severe cases of diabetes, injections of hypoglycemic drugs are required to assist hypoglycemic agents. Injected hypoglycemic drugs mainly include insulin and similar drugs, GLP-1 receptor agonists, etc.; however, the above-mentioned hypoglycemic drugs have some side effects, and the more common side effect is hypoglycemia. After taking them, patients may experience a strong sense of fasting, cold sweats, general weakness, palpitations, and trembling hands and feet. , dizzy eyes, headache, daze, etc. In severe cases, coma and other discomfort symptoms may occur
[0005] Relevant studies have shown that some traditional Chinese medicines also have hypoglycemic effects, and have fewer side effects and a wider range of applications. They are of great significance and help in reducing blood sugar in the human body. It has been shown that ginseng also has hypoglycemic effects. Ginseng peptide is an active ingredient for lowering blood sugar, which plays an important role in regulating blood sugar in the human body. However, the research on the drug application of ginseng polysaccharides and ginseng peptides is still relatively slow. few

Method used

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  • Ginseng glycopeptide injection pharmaceutical composition as well as preparation method and application thereof
  • Ginseng glycopeptide injection pharmaceutical composition as well as preparation method and application thereof
  • Ginseng glycopeptide injection pharmaceutical composition as well as preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0045] A preparation method of a ginseng glycopeptide injection pharmaceutical composition, comprising the following steps:

[0046] S1. First remove the non-medicinal parts of the ginseng such as impurities, mildew, insects, and counterfeit products; secondly, wash the ginseng with running water; Under the same conditions, dry for 2-4 hours until the water contained in ginseng is not higher than 12%; finally, use a high-efficiency coarse pulverizer to crush the ginseng into a coarse powder;

[0047] S2. add 6 times the amount of 50% ethanol to the pretreated ginseng coarse powder for reflux extraction, the extraction time is 2.5 hours, take the filtrate, then use 5.5 times the amount of 50% ethanol to extract the filter residue for 2 hours, take the filtrate, Then use 5.5 times of 50% ethanol to extract the filter residue for 2 hours, remove the filtrate, and combine the three filtrates;

[0048] S3. The three ethanol extracts are concentrated under reduced pressure to a rel...

Embodiment 2

[0059] A preparation method of ginseng glycopeptides, comprising the following steps:

[0060] S1. First remove the non-medicinal parts of the ginseng such as impurities, mildew, insects, and counterfeit products; secondly, wash the ginseng with running water; Under the same conditions, dry for 2-4 hours until the water contained in ginseng is not higher than 12%; finally, use a high-efficiency coarse pulverizer to crush the ginseng into a coarse powder;

[0061] S2. Add 8 times the amount of 50% ethanol to the pretreated ginseng coarse powder for reflux extraction, the extraction time is 3.5 hours, take the filtrate, then use 7.5 times the amount of 50% ethanol to extract the filter residue for 2 hours, take the filtrate, Then use 7.5 times of 50% ethanol to extract the filter residue for 2 hours, remove the filtrate, and combine the three filtrates;

[0062] S3. The three ethanol extracts were concentrated under reduced pressure to a relative density of 1.25.

[0063] S4. ...

Embodiment 3

[0073] A method for preparing ginseng glycopeptides, comprising the following steps:

[0074] S1. First remove the non-medicinal parts of the ginseng such as impurities, mildew, insects, and counterfeit products; secondly, wash the ginseng with running water; Under the same conditions, dry for 2-4 hours until the water contained in ginseng is not higher than 12%; finally, use a high-efficiency coarse pulverizer to crush the ginseng into a coarse powder;

[0075] S2. Add 7 times the amount of 50% ethanol to the pretreated ginseng coarse powder for reflux extraction, the extraction time is 3 hours, take the filtrate, then use 6.5 times the amount of 50% ethanol to extract the filter residue for 2 hours, take the filtrate, Then use 6.5 times of 50% ethanol to extract the filter residue for 2 hours, remove the filtrate, and combine the three filtrates;

[0076] S3. The three ethanol extracts were concentrated under reduced pressure to a relative density of 1.15.

[0077] S4. Add...

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Abstract

The invention specifically discloses a ginseng glycopeptide injection pharmaceutical composition as well as a preparation method and application thereof. The preparation method takes ginsengs as raw materials and comprises the following steps: according to the principle that substances with similar polarities are easily compatible, carrying out a plurality of times of extraction on the ginsengs byutilizing ethanol with the same concentration through pre-treatment procedures of sorting, washing, drying, crushing and the like; then carrying out concentration and alcohol precipitation proceduresto obtain a ginseng glycopeptide crude product; then carrying out freezing, filtering, vacuum decompression and concentration, freezing and drying procedures, and furthermore, purifying and removingimpurities to obtain refined ginseng glycopeptide; then carrying out procedures of washing bottles, weighing, preparing, filling, sterilizing, carrying out lamp inspection, packaging and the like on the ginseng glycopeptide to produce ginseng glycopeptide injection.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a pharmaceutical composition of ginseng glycopeptide injection and its preparation method and application. Background technique [0002] Ginseng (scientific name: Panax ginseng, also known as Asian ginseng, native name "stick" in Northeast China) is a fleshy root that can be used medicinally. Ginseng belongs to Araliaceae, a common medicinal material in Asia, and American ginseng is also widely used in North and Central America. It is mainly used for recovery after recovery, strengthening physical strength, regulating hormones, lowering blood sugar and controlling blood pressure, and controlling liver index and liver function. [0003] Modern medical research and laboratory analysis show that ginseng contains a chemical substance called ginsenoside, which has obvious effects on regulating the central nervous system, strengthening the heart, anti-fatigue, regulating substance met...

Claims

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Application Information

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IPC IPC(8): A61K36/258A61K9/08A61P3/10
CPCA61K9/0019A61K9/08A61K36/258A61K47/26A61K2236/13A61K2236/15A61K2236/17A61K2236/333A61K2236/39A61K2236/51A61K2236/53A61P3/10
Inventor 费青张丹张恒张戈
Owner JILIN BAINIAN HANKE PHARM CO LTD
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