Ginseng glycopeptide injection pharmaceutical composition as well as preparation method and application thereof

A technology of injection and composition, applied in the field of medicine, can solve the problems of patients with cold sweat, general weakness, lack of ginseng glycopeptide hypoglycemic drugs, slow application research, etc., achieves broad market prospects and commercial value, and is suitable for a wide range of people. , the effect of less adverse reactions

Inactive Publication Date: 2018-08-24
JILIN BAINIAN HANKE PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the medicines used to treat hyperglycemia and diabetes are mainly Western medicines for hypoglycemic drugs and insulin injections, while traditional Chinese medicines are used less for hypoglycemics. Western medicines mainly include sulfonylureas and non-sulfonylureas, metformin, and α-glucosides. Oral hypoglycemic drugs such as enzyme inhibitors, thiazolidinedione derivatives, and DPP-4 enzyme inhibitors. In severe cases of diabetes, injections of hypoglycemic drugs are required to assist hypoglycemic agents. Injected hypoglycemic drugs mainly include insulin and similar drugs, GLP-1 receptor agonists, etc.; however, the above-mentioned hypoglycemic drugs have some side effects, and the more common side effect is hypoglycemia. After taking them, patients may exp

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  • Ginseng glycopeptide injection pharmaceutical composition as well as preparation method and application thereof
  • Ginseng glycopeptide injection pharmaceutical composition as well as preparation method and application thereof
  • Ginseng glycopeptide injection pharmaceutical composition as well as preparation method and application thereof

Examples

Experimental program
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Example Embodiment

[0044] Example 1

[0045] A method for preparing a pharmaceutical composition of ginseng glycopeptide injection, comprising the following steps:

[0046] S1. First, remove the non-medicinal parts of ginseng such as impurities, mildew, insects, and fakes; secondly, wash the ginseng with running water; then put it in a hot air circulating oven, and get the temperature at not higher than 60℃ Under the conditions, dry for 2 to 4 hours until the moisture content of the ginseng is not higher than 12%; finally, the ginseng is crushed into coarse powder with a high-efficiency coarse grinder;

[0047] S2. Add 6 times the amount of 50% ethanol to the pre-treated coarse ginseng powder for reflux extraction. The extraction time is 2.5 hours, and the filtrate is taken. Then the filter residue is extracted with 5.5 times the amount of 50% ethanol for 2 hours, and the filtrate is taken. Then extract the filter residue with 5.5 times of 50% ethanol for 2 hours, remove the filtrate, and combine the ...

Example Embodiment

[0058] Example 2

[0059] A preparation method of ginseng glycopeptide includes the following steps:

[0060] S1. First, remove the non-medicinal parts of ginseng such as impurities, mildew, insects, and fakes; secondly, wash the ginseng with running water; then put it in a hot air circulating oven, and get the temperature at not higher than 60℃ Under the conditions, dry for 2 to 4 hours until the moisture content of the ginseng is not higher than 12%; finally, the ginseng is crushed into coarse powder with a high-efficiency coarse grinder;

[0061] S2. Add 8 times the amount of 50% ethanol to the pre-treated ginseng powder for reflux extraction. The extraction time is 3.5 hours, and the filtrate is taken. Then the filter residue is extracted with 7.5 times the amount of 50% ethanol for 2 hours, and the filtrate is taken. Use 7.5 times of 50% ethanol to extract the filter residue for 2 hours, remove the filtrate, and combine the three filtrates;

[0062] S3. The three ethanol extract...

Example Embodiment

[0072] Example 3

[0073] A preparation method of ginseng glycopeptide includes the following steps:

[0074] S1. First, remove the non-medicinal parts of ginseng such as impurities, mildew, insects, and fakes; secondly, wash the ginseng with running water; then put it in a hot air circulating oven, and get the temperature at not higher than 60℃ Under the conditions, dry for 2 to 4 hours until the moisture content of the ginseng is not higher than 12%; finally, the ginseng is crushed into coarse powder with a high-efficiency coarse grinder;

[0075] S2. Add 7 times the amount of 50% ethanol to the pre-treated coarse ginseng powder for reflux extraction. The extraction time is 3 hours, and the filtrate is taken. Then the filter residue is extracted with 6.5 times the amount of 50% ethanol for 2 hours, and the filtrate is taken. Use 6.5 times of 50% ethanol to extract the filter residue for 2 hours, remove the filtrate, and combine the three filtrates;

[0076] S3. The three ethanol ex...

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Abstract

The invention specifically discloses a ginseng glycopeptide injection pharmaceutical composition as well as a preparation method and application thereof. The preparation method takes ginsengs as raw materials and comprises the following steps: according to the principle that substances with similar polarities are easily compatible, carrying out a plurality of times of extraction on the ginsengs byutilizing ethanol with the same concentration through pre-treatment procedures of sorting, washing, drying, crushing and the like; then carrying out concentration and alcohol precipitation proceduresto obtain a ginseng glycopeptide crude product; then carrying out freezing, filtering, vacuum decompression and concentration, freezing and drying procedures, and furthermore, purifying and removingimpurities to obtain refined ginseng glycopeptide; then carrying out procedures of washing bottles, weighing, preparing, filling, sterilizing, carrying out lamp inspection, packaging and the like on the ginseng glycopeptide to produce ginseng glycopeptide injection.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a pharmaceutical composition of ginseng glycopeptide injection and its preparation method and application. Background technique [0002] Ginseng (scientific name: Panax ginseng, also known as Asian ginseng, native name "stick" in Northeast China) is a fleshy root that can be used medicinally. Ginseng belongs to Araliaceae, a common medicinal material in Asia, and American ginseng is also widely used in North and Central America. It is mainly used for recovery after recovery, strengthening physical strength, regulating hormones, lowering blood sugar and controlling blood pressure, and controlling liver index and liver function. [0003] Modern medical research and laboratory analysis show that ginseng contains a chemical substance called ginsenoside, which has obvious effects on regulating the central nervous system, strengthening the heart, anti-fatigue, regulating substance met...

Claims

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Application Information

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IPC IPC(8): A61K36/258A61K9/08A61P3/10
CPCA61K9/0019A61K9/08A61K36/258A61K47/26A61K2236/13A61K2236/15A61K2236/17A61K2236/333A61K2236/39A61K2236/51A61K2236/53A61P3/10
Inventor 费青张丹张恒张戈
Owner JILIN BAINIAN HANKE PHARM CO LTD
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