A kind of preparation method of hydroxyethyl chitosan nanocomposite bone scaffold material

A hydroxyethyl chitosan and nano-composite technology, applied in the field of biomedical materials, can solve problems such as poor mechanical properties, and achieve low cost, simple and easy-to-operate preparation process, and good multiplication effects
CN108478874BActive Publication Date: 2020-11-27XINYANG NORMAL UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
XINYANG NORMAL UNIVERSITY
Publication Date
2020-11-27

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Abstract

The invention relates to a preparation method of a hydroxyethyl chitosan nano composite bone support material. The preparation method comprises the following steps: obtaining phosphorus calcium powderin a precipitating method, roasting, and obtaining hydroxyapatite / beta-tricalcium phosphate two-phase phosphorus calcium nano powder, performing the hydroxyethylation on chitosan, preparing hydroxyethyl chitosan, finally dissolving the hydroxyethyl chitosan in a 1 percent acetum solution, mixing and stirring the hydroxyethyl chitosan, gelatin and two-phase phosphorus calcium nano powder accordingto a mass ratio of (1 to 4) to 1 to (0.5 to 4), degassing, uniformly dispersing, circularly freezing and thawing the solution, and finally drying, thus obtaining the hydroxyethyl chitosan nano composite bone support material. The preparation method is simple in preparation process, easy in operation, capable of realizing the batched preparation, lower in cost, and pollution-free; and by adoptinga ternary material system, a prepared bone support has an appropriate degradation rate, the cell compatibility of the bone support is improved, the biological activity is better, and the cell can be better adhered and proliferated.
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Description

technical field

[0001] The invention relates to a preparation method of a hydroxyethyl chitosan nanocomposite bone scaffold material, belonging to the technical field of biomedical materials. Background technique

[0002] Chitosan is obtained by deacetylation of chitin, which exists widely in nature. This natural polymer has excellent properties such as biocompatibility, blood compatibility, safety, and microbial degradability. One of the better materials. However, chitosan gel needs to be cross-linked during the preparation process, and the cross-linking agent is usually glutaraldehyde. The introduction of the cross-linking agent will reduce the cytocompatibility of the scaffold, and the mechanical properties are also poor.

[0003] Bone tissue contains a large amount of phosphorus-calcium materials, such as tricalcium phosphate, hydroxyapatite, calcium carbonate, etc., so phosphorus-calcium materials are often used to prepare artificial bone scaffolds. Calcium phosphate-...

Claims

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