A kind of hydrophobic polycaprolactone and preparation method thereof

Abstract

The invention discloses a hydrophobic polycaprolactone and a preparation method thereof: react polycaprolactone with an amino alcohol compound to prepare hydroxyl-terminated polycaprolactone; react hydroxyl-terminated polycaprolactone with an acid anhydride to prepare carboxyl-terminated polycaprolactone Polycaprolactone; reacting ethylene glycol bromoisobutyrate with fluorine-containing alkyl acrylate to prepare hydroxyl-terminated fluorine-containing polyacrylate; reacting carboxyl-terminated polycaprolactone with hydroxyl-terminated fluorine-containing polyacrylate, Preparation of hydrophobic polycaprolactone. The molecular weight of the hydrophobic segment of the product of the invention is controllable, the molecular weight distribution is narrow, and the fluorine content and hydrophobicity are controllable. When preparing the hydrophobic polycaprolactone, the end group activated fluorine-containing polymer is pre-prepared to obtain a fluorine-containing polymerization product in a homogeneous system, which is easy to control the degree of polymerization. It solves the problem that it is difficult to generate fluoropolymer chain directly at the PCL chain end in situ due to the change of solubility. The product is prepared by direct condensation of active carboxyl-containing PCL and active hydroxyl-containing organic fluorine polymer under mild reaction conditions, which avoids the degradation of PCL.

Description

technical field

[0001] The invention relates to a polymer modification technology, in particular to a hydrophobic polycaprolactone and a preparation method thereof. Background technique

[0002] Poly-caprolactone (poly-caprolactone, PCL) is a kind of linear aliphatic polyester obtained by ring-opening polymerization of ω-caprolactone monomer under the catalysis of metal organic compounds (such as tetraphenyltin). Degradability, good biocompatibility, drug permeability and mechanical properties have been certified by the US FDA, and have been extensively researched and applied in the field of film applications. Polycaprolactone (PCL) has a melting point of 59-64°C and a glass transition temperature of -60°C. Its structural repeat unit has 5 non-polar methylene-CH 2 - and a polar ester group -COO-, ie -(COOCHCH 2 CH 2 CH 2 CH 2 CH 2 -)Pn, this structure makes PCL have good flexibility and processability, and this material has good biocompatibility.

[0003] At present,...

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