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Rapid preparation method of bioglass/hydrogel composite material

A bioglass and composite material technology, applied in tissue regeneration, medical science, prosthesis, etc., can solve the problems of poor dispersion and easy agglomeration, and achieve the effect of easy operation, excellent performance and low time consumption

Inactive Publication Date: 2018-09-28
FUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The purpose of the present invention is to provide a rapid preparation method of bioglass / hydrogel composite material with simple operation process, fast preparation and good biocompatibility, which can be widely used in the field of biomedicine The combination with hydrogel can improve the poor dispersion and easy agglomeration of bioglass in the organism, so as to prepare composite materials with good biocompatibility and good bioactivity

Method used

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  • Rapid preparation method of bioglass/hydrogel composite material
  • Rapid preparation method of bioglass/hydrogel composite material
  • Rapid preparation method of bioglass/hydrogel composite material

Examples

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Effect test

Embodiment 1

[0026] A rapid preparation method of bioglass / hydrogel composite material, comprising the following steps:

[0027] (1) 58S bioglass powder (58SiO 2 -33CaO-9P 2 o 5 ) after ball milling and sieving to obtain a powder with a particle size of less than 45 microns, put it into constant temperature water at 37 °C and continuously pass nitrogen gas to remove dissolved oxygen in the water, add cerium ammonium nitrate solution with a concentration of 0.1mol / L and magnetically stir Fully react for 30 min, then drop polyglycidyl methacrylate (GMA) for 30 min, react for 1 h, wash repeatedly with deionized water and absolute ethanol until neutral, centrifuge and dry to obtain the powder diamine: water = 3:2 in 125 mL mixed solution, and stirred at 80 °C for 1 h, and finally washed with deionized water and ethanol repeatedly until neutral, then centrifuged and dried to obtain surface amination-modified Bio-glass powder;

[0028] (2) Dissolve 3 g of chitosan in 50 g of dilute acetic ac...

Embodiment 2

[0033] A rapid preparation method of bioglass / hydrogel composite material, comprising the following steps:

[0034] (1) 45S5 bioglass powder (45SiO 2 -24.5CaO-6P 2 o 5 -24.5Na 2O) After ball milling, sieve to obtain a powder with a particle size of less than 45 microns, put it into constant temperature water at 37 °C and continuously pass nitrogen gas to remove dissolved oxygen in the water, and add cerium ammonium nitrate solution with a concentration of 0.1 mol / L to magnetically Stir and react for 30 minutes, then add polyglycidyl methacrylate (GMA) dropwise for 30 minutes. After reacting for 1 hour, wash with deionized water and absolute ethanol repeatedly until neutral, and centrifuge and dry to obtain powder. Ethylenediamine: water = 3:2 in 125 mL mixed solution, and stirred at 80 °C for 6 h, and finally washed with deionized water and ethanol repeatedly to neutrality, then centrifuged and dried to obtain surface amination-modified Bio-glass powder;

[0035] (2) Diss...

Embodiment 3

[0040] A rapid preparation method of bioglass / hydrogel composite material, comprising the following steps:

[0041] (1) 35SiO 2 -40CaO-25P 2 o 5 The bioglass powder is ball-milled and sieved to obtain a powder with a particle size below 45 microns, which is placed in constant temperature water at 37 °C and nitrogen gas is continuously passed through to remove dissolved oxygen in the water, and cerium ammonium nitrate solution with a concentration of 0.1 mol / L is added Magnetic stirring was used to fully react for 30 min, then polyglycidyl methacrylate (GMA) was added dropwise for 30 min, and after reacting for 1 h, it was repeatedly washed with deionized water and absolute ethanol until neutral, and the powder obtained by centrifugal drying was put into the ratio of ethylenediamine:water=3:2 in 125 mL mixed solution, and stirred at 80 ℃ for 3.5 h, and finally washed with deionized water and ethanol repeatedly until neutral, then centrifuged and dried to obtain surface aminat...

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Abstract

The invention belongs to the field of biological functional materials, and discloses a rapid preparation method of a bioglass / hydrogel composite material. The rapid preparation method comprises the following steps that the surface active site of bioglass powder is improved by amino surface modification of the bioglass powder, and polyethylene glycol (DFPEG) with benzaldehyde groups at double endsis synthesized and used as a gelator cross-linked bioglass / chitosan composite solution, so that the bioglass / hydrogel composite material can be prepared rapidly. The rapid preparation method is simple and efficient, and used raw materials are cheap and easy to obtain. The prepared bioglass / hydrogel has good biocompatibility, and can be applied to the biomedical fields such as repair of wound defects, drug controlled release, growth factors and cell culture. The rapid preparation method of the bioglass / hydrogel composite material has the advantages of simple process, easy operation and rapidpreparation, and has a good application prospect.

Description

technical field [0001] The invention relates to the field of biofunctional materials, in particular to a rapid preparation method of bioglass / hydrogel composite materials. Background technique [0002] Today, with the continuous development of science and technology, biomaterials, as the cross-frontier field of life science and materials science, plays an inestimable role in human rehabilitation engineering. Bioglass (BG) is an important branch of biomedical materials, mainly composed of silicate glass materials, and the main component is SiO 2 and CaO. It has good biocompatibility, no toxic and side effects, and forms new bone tissue through direct chemical bonding and biodegradation with the human body. BG also has good biodegradability and biocompatibility, can promote the regeneration of bone tissue and soft tissue, and has a high degree of biological activity. BG not only has good biological activity, but also can promote the growth of hard tissue and soft tissue, an...

Claims

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Application Information

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IPC IPC(8): A61L27/10A61L27/52A61L27/54A61L27/20A61L27/18A61L27/50
CPCA61L27/10A61L27/18A61L27/20A61L27/50A61L27/52A61L27/54A61L2300/10A61L2300/412A61L2430/02C08L5/08C08L71/02
Inventor 温翠莲裘依梅吴军茹李瑞峰叶健霞张腾温娜
Owner FUZHOU UNIV
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