A kind of calcium polyphosphate surface polydopamine modified composite bioceramics and preparation method thereof
A composite bioceramic and calcium polyphosphate technology, applied in tissue regeneration, medical science, prosthesis, etc., to achieve the effects of high degradability, good biocompatibility, good bioactivity and biocompatibility
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Embodiment 1
[0074] A preparation method of polydopamine-modified calcium polyphosphate composite bioceramics, comprising the steps of:
[0075] 1) Preparation of CPP base material: Pour 100g of calcium dihydrogen phosphate raw material into a clean crucible. The upper part of the crucible should be covered but not sealed. ℃, heat preservation for 10h to carry out primary sintering, after the furnace cools down, take out the powder material for primary sintering, grind it into powder, then mix these powders with 1g of polyvinyl alcohol with a mass fraction of 5% to obtain a mixture, according to the ball water 1: Pour the ratio of 2:1 into a ball mill tank and mill at a speed of 230r / min for 30min. Dry the milled slurry at 50°C and pass it through a 200-mesh sieve. 3:7 mixed evenly, carry out dry compression molding (compression molding conditions: pressure 1Mpa, hold pressure 1min) to obtain the green body; finally, the pressed green body is raised to 400°C at a rate of 4°C / min Keep it w...
Embodiment 2
[0080] A preparation method of polydopamine-modified calcium polyphosphate composite bioceramics, comprising the steps of:
[0081] 1) Preparation of CPP base material: Same as Example 1.
[0082] 2) Pretreatment of CPP base material: same as embodiment 1.
[0083] 3) Prepare 1g / L PDA solution: Dissolve 0.6060g Tris-HCl in 450ml deionized water, put it on a magnetic stirrer and stir at 37°C for 30min, then adjust the pH to 8.5 with 1mol / L HCl; then take 50ml Pour the prepared Tris-HCl solution into a container, heat it up to 37°C in a magnetic stirrer, stir for 30 minutes, add 0.05 g of dopamine hydrochloride crystals and stir to obtain the product.
[0084] 4) Preparation of PDA-CPP composite ceramic material: put the CPP prepared in step 1 into the PDA solution prepared in step 2), and soak in a constant temperature water bath at 37°C for 5min, 10min, 15min, 30min, 1h, 2h, 4h Then take them out, rinse them with deionized water three times, and dry them at 50°C for 4 hours,...
Embodiment 3
[0086] A preparation method of polydopamine-modified calcium polyphosphate composite bioceramics, comprising the steps of:
[0087] 1) Preparation of CPP base material: Pour 100g of calcium dihydrogen phosphate raw material into a clean crucible. The upper part of the crucible should be covered but not sealed. ℃, keep warm for 15 hours for primary sintering, take out the primary sintered powder after the furnace cools down, grind it into powder, and then mix these powders with 0.1g of polyvinyl alcohol with a mass fraction of 10% to obtain a mixture, according to the ball water 1 Pour the ratio of 1:1 into a ball mill tank and mill at a speed of 300r / min for 20min, dry the milled slurry at 45°C and pass it through a 100-mesh sieve. Ratio 3:7 mixed evenly, carry out dry pressing molding (the condition of pressing molding is: pressure is 0.5Mpa, hold pressure 2min), obtain green body; Hold at 300°C for 4 hours, raise to 700°C at a rate of 1°C / min, hold for 120 minutes, wait for...
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