Warfarin micro-tablet and preparation method thereof
A technology of warfarin and microtablets, which is applied in the direction of pharmaceutical formulas, medical preparations of non-active ingredients, pill delivery, etc., which can solve the problem of inability to meet the requirements of individualized medication, the dose cannot achieve the anticoagulant effect, and the accuracy cannot be achieved Drug administration and other issues, to achieve the ideal drug release rate, flexible and accurate dosage, and reduce the effect of high local blood drug concentration
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Embodiment 1
[0024]
[0025]
[0026] The preparation process is as follows: put warfarin sodium, pregelatinized starch, microcrystalline cellulose 102 and HPMC E3 in the pot of the wet granulator, turn on the paddle for 10 minutes of initial mixing, after mixing, turn on the paddle and spray in at the same time Purified water was used for wet granulation; after spraying the purified water, the granulation was continued for 2 minutes; then the obtained wet granules were subjected to wet granulation, and then put into a fluidized bed for drying. After drying, the granules were subjected to dry granulation; the dry granules were After being uniformly mixed with the prescribed amount of magnesium stearate, the mixed material is transferred to a high-speed rotary tablet press for tableting to obtain finished tablets.
Embodiment 2
[0028] name
[0029]Preparation process: put warfarin sodium, microcrystalline cellulose 102, lactose Flowlac100, and sodium alginate in the pot of the wet granulator, turn on the paddle for 10 minutes of initial mixing, after mixing, turn on the paddle and spray purified water at the same time Carry out wet process; continue to granulate for 2 minutes after the purified water is sprayed; then wet granules are subjected to wet sizing, and then put into a fluidized bed for drying, after drying, the granules undergo dry sizing; the dry granules are mixed with the prescription amount After the magnesium stearate is uniformly mixed, the mixed material is transferred to a high-speed rotary tablet press for tableting to obtain finished tablets.
Embodiment 3
[0031] warfarin sodium
[0032] Preparation process: Put warfarin sodium, microcrystalline cellulose 102 and sodium alginate in the pot of the wet granulator, turn on the paddle for 10 minutes of initial mixing, after the mixing is complete, turn on the paddle and spray purified water at the same time for wet granulation Continue granulation for 2min after the purified water is sprayed into; then the obtained wet granules are wet sized, then put into a fluidized bed for drying, and the dried granules are dry sized; After the magnesium is uniformly mixed, the mixed material is transferred to a high-speed rotary tablet press for tablet compression to obtain finished tablets.
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