Application of small molecular hyaluronic acid fragment

Abstract

Based on the clinical experimental study of a small molecular hyaluronic acid fragment in small animals, large animals and human body, a series of novel uses of the hyaluronic acid fragment for injection are discovered. The experimental results show that the small molecular hyaluronic acid fragment has an unexpected therapeutic effect on various diseases when injected, and has the effects of rapidly relieving pain, relieving itching and increasing physical and mental strength, thereby making the small molecular hyaluronic acid fragment have great application value in the preparation of treatment or adjuvant treatment drugs for related diseases. In addition, the experimental results also show that the small molecular hyaluronic acid fragment can reduce subcutaneous fat, especially in the head, face and neck of the human body. Meanwhile, the small molecular hyaluronic acid fragment also has the effects of facial beauty and anti-aging, and can be injected through an abdominal subcutaneousfat layer when used without facial injection, and causes no pain and facial inflammation. Thus, the small molecular hyaluronic acid fragment also has a prominent application potential in the field ofbody shaping and cosmetology.

Description

technical field [0001] The present invention relates to the field of application of small molecular hyaluronic acid fragments, in particular to the application of small molecular hyaluronic acid fragments in the preparation of medicines for treating various diseases including solid tumors, as well as in facial beauty, increasing physical strength and energy, Uses such as reducing subcutaneous fat. Background technique [0002] Hyaluronic acid, also known as hyaluronic acid, uronic acid, hyaluronic acid, English name hyaluronic acid (referred to as HA), is a high-level polysaccharide composed of D-glucuronic acid and N-acetylglucosamine, and the number of disaccharide units can reach 25,000 you. Tissues such as human subcutaneous tissue, epidermis and oropharyngeal mucosa contain a large amount of macromolecular hyaluronic acid. In other words, macromolecular hyaluronic acid is the basic building material of various tissues such as human skin, mucous membranes, and subcutan...

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Problems solved by technology

However, the recent patent WO / 2014 / 165713 of CEDARS-SINAI MEDICAL CENTER shows that the small molecule hyaluronic acid produced by bacterial streptococci hyaluronidase cutting less than 10KD does not cause inflammation, but the bacterial Streptomyces hyaluronidase produces more than 10KD However, the small molecule hyaluronic acid caused inflammation, suggesting that the function of the small molecule hyaluronic acid may also be related to the type of cutting enzyme (that is, related to the three-dimensional structure or molecular arrangement of the cleaved hyaluronic acid fragments)

[0022] The above contradictory research results suggest that the exact function of small-molecule hyaluronic acid fragments is currently difficult to determine. Perhaps the production method, molecular weight, type of cutting enzyme, and method of use of small-molecule hyaluronic acid fragments may affect their functional performance. However, in addition to these known and possible factors, there are still many other unknown factors that researchers are not sure about. For example, there are no reliable experimental results on large animals.

Therefore, although people in the industry pin their hopes on the medical value of small molecule hyaluronic acid, it is still difficult to predict the success of clinical research and druggability of small molecule hyaluronic acid, especially to determine the clinical indications

Although our previous research obtained a feasible and effective small-molecule hyaluronic acid in vitro preparation, due to the complex internal environment of the human body, the in vivo injection of small-molecule hyaluronic acid may be completely different from the in vitro preparation. , the effects in large animals and small animals may not be the same, therefore, it needs to be verified by clinical research

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