Chitosan quaternary ammonium salt containing organic acid salt as well as preparation method and application thereof

A technology of chitosan quaternary ammonium salt and organic acid salt, which is applied in the field of chitosan quaternary ammonium salt and its preparation, can solve problems such as application limitations, and achieve the effects of low material cost, wide application value, and wide application prospects

Active Publication Date: 2018-11-06
YANTAI INST OF COASTAL ZONE RES CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because chitosan can only be dissolved in a few organic solvents such as acetic acid and water with pH<4, which limits its wide application, chitosan is chemically modified to improve its solubility and broaden its application. range is necessary

Method used

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  • Chitosan quaternary ammonium salt containing organic acid salt as well as preparation method and application thereof
  • Chitosan quaternary ammonium salt containing organic acid salt as well as preparation method and application thereof
  • Chitosan quaternary ammonium salt containing organic acid salt as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028]

[0029] The structural formula of chitosan quaternary ammonium salt containing gallic acid is as formula (1), wherein the average value range of n is 300-900.

[0030] Preparation of chitosan quaternary ammonium salt: using chitosan, 3-chloro-2-hydroxypropyltrimethylammonium chloride, sodium hydroxide, isopropanol and halogenated acetic acid compounds as raw materials, take 1g chitosan Disperse the sugar in 20mL of isopropanol and swell, stir at room temperature for 4 hours, add 6mL of 3-chloro-2-hydroxypropyltrimethylammonium chloride and 1g of sodium hydroxide solution in sequence, and continue the reaction at 75°C for 12 hours. Then precipitate with an appropriate amount of ethanol, wash, and dry at 65° C. to obtain chitosan quaternary ammonium salt.

[0031] The chitosan quaternary ammonium salt 1g was dissolved in water, dialyzed in 100mL1.5% sodium gallate solution for 12 hours, then removed the sodium gallate solution, dialyzed in distilled water for 24h, con...

Embodiment 2

[0035]

[0036] The structural formula of the chitosan quaternary ammonium salt containing caffeic acid is as formula (2), wherein the average value range of n is 300-900.

[0037] The difference from Example 1 is:

[0038] Using chitosan, 3-chloro-2-hydroxypropyltrimethylammonium chloride, sodium hydroxide, isopropanol and other compounds as raw materials, take 1.2g of chitosan and disperse it in 30mL of isopropanol for swelling. Stir under conditions for 4 hours, add 9mL of 3-chloro-2-hydroxypropyltrimethylammonium chloride and 1.2g of sodium hydroxide solution in turn, continue to react for 12 hours at 75°C, then precipitate with an appropriate amount of ethanol, wash, and dry To obtain chitosan quaternary ammonium salt.

[0039] The chitosan quaternary ammonium salt 1.2g was dissolved in 20mL distilled water, dialyzed in 100mL3% sodium caffeate solution for 12 hours, then removed the sodium caffeate solution, dialyzed in distilled water for 24h, concentrated and then f...

Embodiment 3

[0042]

[0043] The structural formula of the chitosan quaternary ammonium salt containing ascorbic acid is as formula (3), wherein the average value range of n is 300-900.

[0044] The difference from Example 1 is:

[0045] Using chitosan, 3-chloro-2-hydroxypropyltrimethylammonium chloride, sodium hydroxide, isopropanol and other compounds as raw materials, take 1.5g of chitosan and disperse it in 40mL of isopropanol for swelling. Stir under condition for 4 hours, add 12mL of 3-chloro-2-hydroxypropyltrimethylammonium chloride and 1.5g of sodium hydroxide solution in turn, continue to react for 12 hours at 75°C, then precipitate and wash with an appropriate amount of ethanol to obtain a shell Polysaccharide quaternary ammonium salt.

[0046] The chitosan quaternary ammonium salt 1.5g was dissolved in 20mL distilled water, dialyzed in 100mL4.5% sodium ascorbate solution for 12 hours, then removed the sodium ascorbate solution, dialyzed in distilled water for 24h, concentrat...

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Abstract

The invention relates to the technical field of marine chemical engineering, in particular to chitosan quaternary ammonium salt containing organic acid salt as well as a preparation method and application thereof. Chitosan, 3-chloro-2-hydroxypropyltrimethyl ammonium chloride, sodium hydroxide, isopropanol, gallic acid, caffeic acid and ascorbic acid are used as raw materials; firstly, the chitosanis dispersed in isopropanol for swelling expansion; at room temperature stirring is performed for 4h; 3-chloro-2-hydroxypropyltrimethyl ammonium chloride and a sodium hydroxide solution are added; continuous reaction is performed for 12h; then, a proper amount of ethyl alcohol is used for precipitation; the chitosan quaternary ammonium salt is obtained; finally, the chitosan quaternary ammonium salt is dissolved in water; ion exchange with the organic acid salt is performed; a final product is obtained. The chitosan quaternary ammonium salt has the advantages that active groups in derivativesare added; the activity is high; the preparation process is simple; side reaction is little; the cost of the used materials is low. The research proves that the derivatives have good water solubility; the antioxidant activity is high; wide application values are realized in the industry of medicine and functional food health care, particularly cosmetics industry.

Description

technical field [0001] The invention relates to the technical field of marine chemical engineering, in particular to a chitosan quaternary ammonium salt containing an organic acid salt and a preparation method and application thereof, which can be applied to the fields of medicine, functional food health care, cosmetics and the like. Background technique [0002] Chitosan (CTS) is a natural polymer compound with a deacetylation degree of more than 50% of chitin. It not only maintains the biocompatibility of chitin, but also has significantly improved application performance compared with chitin. However, because chitosan can only be dissolved in a few organic solvents such as acetic acid and water with pH<4, which limits its wide application, chitosan is chemically modified to improve its solubility and broaden its application. Range is necessary. Chitosan quaternary ammonium salt has better biological activity than chitosan, and greatly improves the water solubility of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/08A61K8/73A61K31/722A61P39/06A61Q19/08A23L33/125
CPCA23V2002/00A61K8/736A61K31/722A61Q19/08A23L33/125A61P39/06C08B37/003A23V2200/30A23V2250/511
Inventor 郭占勇宓英其张晶晶王刚李青
Owner YANTAI INST OF COASTAL ZONE RES CHINESE ACAD OF SCI
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