A kind of synthesis technique of creatine ethyl ester hydrochloride

Abstract

The invention provides a new synthesis process of creatine ethyl ester hydrochloride, the synthesis steps are as follows: using creatine in absolute ethanol, using 4-dimethylaminopyridine (DMAP) as a catalyst, thionyl chloride or carbon Acyl chloride is a reactive dehydrating agent, which can be reacted at low temperature to produce creatine ethyl ester hydrochloride. The catalyst effectively improves the esterification reaction speed between creatine and ethanol, reduces the occurrence of creatinine side reactions, and improves the purity of creatine ethyl ester hydrochloride. The overall process basically belongs to normal temperature and pressure process, with low energy consumption, high creatine conversion rate and high product purity.

Description

technical field [0001] The invention relates to the field of organic synthesis, in particular to a synthesis process of ethyl creatine hydrochloride. Background technique [0002] Creatine ethyl ester hydrochloride is a derivative of creatine. Creatine is a naturally occurring amino acid derivative that can quickly provide energy and enhance muscle strength and explosive power. It can effectively relieve fatigue and relieve anxiety, loneliness, irritability, depression and other moods. Creatine is also used in the treatment of various disorders such as Parkinson's disease, Huntington's disease, various neuromuscular disorders, brain hypoxic diseases such as stroke, various muscle disorders, rheumatism, skin diseases and heart disease. In recent years, studies at home and abroad have found that supplementing creatine can increase the content of phosphocreatine in muscles and increase the utilization rate of ATP (adenosine triphosphate), thereby increasing the maximum contrac...

AI Technical Summary

Problems solved by technology

[0012] So far, scientists have developed a series of effective synthesis methods of creatine ethyl ester hydrochloride. During the synthesis process using creatine as raw material, it is difficult to effectively avoid the formation of creatinine through cyclization reaction of creatine under acidic conditions. , so the overall synthesis yield and purity are relatively low, and the requirements for the purification process in the later stage are relatively high, resulting in high production costs of creatine ethyl ester hydrochloride, which restricts the use of creatine ethyl ester hydrochloride as a functional additive in functional foods and pharmaceuticals application in

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