3D printed PCL-PDA-lithium ion bone repair tissue engineering scaffold and preparation method thereof

Abstract

The invention discloses a 3D printed PCL-PDA-lithium ion bone repair tissue engineering scaffold and a preparation method thereof. The preparation method comprises: preparing a 3D printed PCL scaffoldthrough a melt extrusion molding 3D printing technology so that the dopamine is self-polymerized on the fiber surface of the 3D printed PCL scaffold to form a PDA coating, and loading lithium chloride to the fiber surface of the 3D printed PCL-PDA scaffold through an in-situ reduction method. The scaffold has the advantages of the existing bone repair material, and fully exerts the performances of the 3D printing technology and the scaffold material, so that the scaffold has the advantages of simple and reliable structure, controllable shape and microstructure, reliable mechanical property, controllable ion release performance, convenient implant, small trauma and low cost and can be used for the repair of bone defects after bone trauma, bone tumor and bone infection.

Description

technical field [0001] The invention belongs to the field of bioengineered human implants, and relates to a 3D printed PCL-PDA-lithium ion bone repair tissue engineering scaffold and a preparation method. Background technique [0002] Clinically, bone defects caused by bone trauma, bone tumors, and bone infections are very common. Every year, a large number of patients with bone tissue defects in my country need surgical treatment. Finding bone tissue engineering repair materials with good biological properties has always been a hot spot in orthopedic research. How to find more and better bone tissue regeneration repair materials to repair human life and recreate health has become the common pursuit and tireless pursuit of many scientists around the world. research impetus. [0003] Although there are many treatments for bone defect repair, these methods generally have many problems such as few sources, many complications, immune rejection and iatrogenic infection, especial...

AI Technical Summary

Problems solved by technology

Including: 1. Autologous bone transplantation, which is limited by the limitation of its own donors and cannot be used repeatedly in large quantities; 2. Allogeneic bone transplantation, which mainly has problems such as immune rejection, pathogen transmission, and high cost; 3. Various Artificial bone substitute materials made of metals, ceramics or polymers have been used clinically, but most of them are used as permanent implants. They cannot participate in the metabolism of the human body, so the long-term effect is often unsatisfactory

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