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Biodegradable magnesium alloy blood vessel rack

A magnesium alloy blood vessel and biodegradation technology, applied in stents, medical science, prostheses, etc., can solve problems such as acute or chronic inflammatory reactions, uncertain plastic deformation points of polymers, and disordered growth of vascular endothelial cells. Achieving excellent mechanical properties, good biocompatibility, and grain refinement

Active Publication Date: 2007-01-03
LIAONING YINYI BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the main materials used to make vascular stents at home and abroad are stainless steel, titanium-nickel alloy and cobalt-chromium alloy, but these permanent metal stents will have the following disadvantages during the long-term implantation process: The permanent implant remains on the inner wall of the blood vessel, and the physical stimulation of the tension that does not match the blood vessel becomes a one-way side effect foreign body. Long-term stimulation causes the growth disorder of vascular endothelial cells, and also causes local chronic inflammation. Therefore, the blood vessel The brace preferably disappears after it has done its supporting role
Some biodegradable polymers have attracted the attention of many research experts, but due to the uncertain plastic deformation point of the polymer itself, the radial support force of the fabricated stent is small, so a large volume is required to apply Its mechanical requirements as a vascular stent can easily cause acute or chronic inflammatory reactions

Method used

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Experimental program
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Effect test

Embodiment 1

[0021] A biodegradable magnesium alloy vascular stent, which is composed of: 5%-8% zinc; 0.5-5% calcium; 1%-3% zirconium; 1%-3% neodymium; 0-3% niobium, The rest is magnesium. Its physical and chemical properties, especially the degradable properties can be adjusted by adding other metal elements with good biocompatibility; especially the degradable properties can be adjusted by adding other rare earth elements with good biocompatibility ; Its biocompatibility can be adjusted by adding other metal elements and rare earth elements with good biocompatibility; its processability can be adjusted by adding other metal elements with good biocompatibility.

Embodiment 2

[0023] A biodegradable magnesium alloy blood vessel stent is composed of: 7% zinc; 0.5% calcium; 1% zirconium; 1% neodymium; the rest is magnesium. The physical properties of the material were measured after further processing into shaped materials: the tensile strength was 220Mpa; the modulus of elasticity was 20Gpa; the elongation at break was 8%; and the degradation half-life in vitro was 8 weeks.

Embodiment 3

[0025] A biodegradable magnesium alloy blood vessel stent is composed of 5% zinc; 2% calcium; 3% zirconium; 3% neodymium; 3% niobium, and the rest is magnesium. The physical properties of the material were measured after further processing into shaped materials: the tensile strength was 270Mpa; the modulus of elasticity was 35Gpa; the elongation at break was 5%; and the degradation half-life in vitro was 12 weeks.

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Abstract

The biodegradable magnesium alloy blood vessel rack consists of magnesium in 60-95 wt% and other metals, including RE, for the rest. Metal magnesium as the basic material has excellent tissue compatibility and blood compatibility, and the added other metal, including RE, elements raise and improve the comprehensive performance, especially mechanical strength, plasticity, degradability and biocompatibility. The magnesium alloy blood vessel rack has tensile strength of 200-300 MPa, elastic module of 10-50 GPa, elongation at break of 2-10%and degrading half life of 6-18 weeks. Most of the degraded metal ions are drained through renal tubules while small part being utilized by human body.

Description

technical field [0001] The invention relates to a vascular stent, in particular to a biodegradable magnesium alloy vascular stent applied to human hearts and brain vessels, and belongs to the field of biomedical engineering. technical background [0002] In foreign countries, the research on PTCA (percutaneous transluminal coronary angioplasty) was first carried out in 1977. The first case of PTCA in China was completed in 1984. Its mechanism of action is to deliver the balloon catheter to the coronary artery lesion, pressurize Inflate the balloon to increase the inner diameter of the stenotic vessel segment, thereby improving blood supply to the myocardium. Coronary artery stenting is developed on the basis of PTCA. It compresses the metal stent on the balloon to support the inner wall of the diseased or narrowed coronary artery, and expands the narrowed or collapsed vessel wall to a normal state. It is the current technology for the treatment of coronary heart disease. It...

Claims

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Application Information

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IPC IPC(8): A61L27/04A61L27/50A61L31/02A61F2/82
Inventor 李昕跃焦延鹏
Owner LIAONING YINYI BIOTECH CO LTD
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