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Biopolysaccharide material composition for treatment of oral mucosal ulcer in chemoradiotherapy patients

A material composition and biological polysaccharide technology, applied in the field of medicine, can solve the problems of slow effect, easy recurrence, unsatisfactory effect, etc., and achieve the effect of quick effect, promoting healing, and promoting wound healing

Pending Publication Date: 2018-12-18
赵岩
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Clinically, there are also various traditional Chinese medicine preparations, antibiotics, hormones and biological agents, etc., but the effect is not ideal, the effect is slow, and it is easy to recur. It is difficult to effectively solve the problem of secondary mucosal ulcer trauma caused by radiotherapy and chemotherapy for cancer patients.

Method used

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  • Biopolysaccharide material composition for treatment of oral mucosal ulcer in chemoradiotherapy patients
  • Biopolysaccharide material composition for treatment of oral mucosal ulcer in chemoradiotherapy patients

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030]4 grams of lentinan, 8 grams of astragalus polysaccharide, 13 grams of chitosan, and a total of 15 grams of other biologically active polysaccharides (including 10 grams of polysaccharides and 5 grams of chitosan oligosaccharides) were dissolved in 940 ml of deionized water. Then add 20 grams of the adhesive agent sodium carboxymethyl cellulose, dissolve completely, and sterilize by ultrahigh pressure to prepare a viscous liquid of the biological polysaccharide composition.

[0031] After the rat was anesthetized with chloral hydrate, the rat was placed prone on the fixed board, and the wound experiment was carried out at approximately the same position on the left and right sides of the rat's spine. There was a wound on the left and right, and the diameter of the wound was 10mm. and genuine leather). The left wound was smeared with biological polysaccharide composition, and the right wound was used as its own control group. After smearing, the animals in each group wer...

Embodiment 2

[0033] 6 grams of lentinan, 12 grams of astragalus polysaccharide, 25 grams of chitosan, and 25 grams of chitooligosaccharide were dissolved in 902 ml of deionized water. Then add 25 grams of sodium carboxymethylcellulose and 5 grams of citric acid as adhesives, dissolve completely, and sterilize by ultrahigh pressure to prepare a viscous liquid of the biological polysaccharide composition.

[0034] Minipigs were anesthetized by intravenous administration of ketamine (20 mg / kg). After anesthesia, the animals were prepared before operation. During the operation, isoflurane (1.0-1.5%), oxygen and nitrogen dioxide were inhaled through the mouth and nose with a breathing mask for anesthesia monitoring, and the depth of anesthesia was maintained. The hair was shaved with an electric pusher, the back skin was prepared with a skin knife, the skin was rinsed with soap and water, and then disinfected with alcohol and iodine, and a No. 11 scalpel was used to cut a full-thickness skin in...

Embodiment 3

[0036] 8 grams of lentinan, 10 grams of astragalus polysaccharide, 12 grams of chitosan, and 50 grams of other biologically active polysaccharides (including 25 grams of hyaluronic acid and 25 grams of chitosan oligosaccharide), were dissolved in 898 ml of deionized water. Then add 22 grams of carboxymethyl chitosan as an adhesive agent, dissolve completely, and sterilize by ultrahigh pressure to prepare a viscous liquid of biological polysaccharide composition.

[0037] Volunteers were breast cancer patients who developed oral ulcers after three cycles of CE chemotherapy. Apply the polysaccharide composition to the wound, once a day in the morning, noon and evening, for a total of 3 days. It can be seen that the biopolysaccharide composition can quickly and significantly promote the repair of oral ulcer wounds.

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Abstract

Directed at the problem of secondary mucosal tissue trauma generated to cancer patients after chemoradiotherapy, the invention provides a biopolysaccharide material composition for treatment of oral mucosal ulcer in chemoradiotherapy patients. The composition is characterized by comprising the following components by weight percentage: 1.3-36.1% of a biopolysaccharide material, 0.1-15% of an adhesive, and the balance deionized water. The composition has the functions of inhibiting pathogenic bacteria, promoting wound healing, reducing inflammatory reaction, etc., and provides an effective therapeutic scheme for ulcers of cancer patients undergoing chemoradiotherapy.

Description

technical field [0001] The invention relates to the field of medicine, and specifically provides a biological polysaccharide material composition for treating oral mucosal ulcers in patients undergoing radiotherapy and chemotherapy. Background technique [0002] With the gradual increase in the incidence of malignant tumors, the promotion of radiotherapy and chemotherapy and the popularization of intracavitary irradiation, in order to improve the long-term survival rate of patients with malignant tumors, radiotherapy formula chemotherapy has gradually become an important method for the treatment of malignant tumors. Oral ulcer is one of the most common and painful side effects in cancer patients receiving systemic radiotherapy and chemotherapy. Oral ulcers seriously affect the daily activities of patients, including eating, drinking, swallowing, speaking, etc., reducing the quality of life, leading to malnutrition, decreased immunity, and even systemic infection. The incide...

Claims

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Application Information

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IPC IPC(8): A61K31/715A61P1/02A61P35/00A61L26/00
CPCA61K31/715A61L26/0023A61L26/0066A61P1/02A61P35/00
Inventor 赵岩柳云恩肖克沈韩涛
Owner 赵岩
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