A kind of silk fibroin hollow fiber containing mugwort microcapsules and its preparation method
A technology of silk fibroin and microcapsules is applied in the directions of microcapsule preparation, microsphere preparation, hollow filament manufacturing, etc., and can solve the problems of short effective time, difficult to popularize and use wormwood essential oil products, and volatile wormwood essential oil, etc. Achieve the effect of enhancing sustained release performance, improving filling rate and utilization rate of microcapsules, and prolonging the diffusion time of essential oils
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Embodiment 1
[0030] Embodiment one: a kind of silk fibroin hollow fiber containing wormwood microcapsules, such as figure 1 As shown, it includes a hollow silk fibroin fiber 1, which is obtained by degumming silk fibroin, and the cavity of the silk fibroin hollow fiber 1 is provided with several wormwood microcapsules 2, Wormwood microcapsules 2 contain wormwood essential oil, which can slowly volatilize into the external environment through wormwood microcapsules 2 and silk fibroin control fibers. Artemisia wormwood microcapsule 2 is prepared by freeze-drying after complex coacervation method with gum arabic, gelatin, and wormwood essential oil. And the particle size of the wormwood microcapsules 2 is 50-1200nm, preferably 100-500nm; in this way, the surface area of the wormwood microcapsules 2 can be ensured, which is conducive to drug release, and the smaller diameter is convenient for spinning.
[0031] The wormwood essential oil in the wormwood microcapsules 2 can volatilize throug...
Embodiment 2
[0032] Embodiment 2: A method for preparing a silk fibroin hollow fiber containing mugwort microcapsules described in Embodiment 1. Such as figure 2 As shown, the preparation of wormwood microcapsules 2 is carried out first: first, heat and dissolve gum arabic and gelatin in deionized water at a ratio of 4%, add wormwood essential oil and dispersant, stir for 40min at a speed of 2000r / min, and adjust with 10% acetic acid PH to 3, stir with a magnetic stirrer for 30min, the speed is 2000r / min, cool the system to 1°C, and in a low temperature environment, add 10% sodium hydroxide solution until the pH is 9, the stirring speed of the stirrer is 2000r / min, and the stirring time is 20min After returning to room temperature, add 25% glutaraldehyde and stir for 3 hours and tannic acid for 4 hours. After the stirring is completed, put it into the drier and dry for 12 hours; The diameter is in the range of 100-500nm.
[0033] Then proceed to the preparation of silk fibroin hollow fi...
Embodiment 3
[0036] Embodiment 3: A method for preparing a silk fibroin hollow fiber containing mugwort microcapsules described in Embodiment 1. Such as figure 2 As shown, the preparation of wormwood essential oil microcapsules: first, heat and dissolve gum arabic and gelatin in deionized water at a ratio of 4%, add wormwood essential oil and dispersant, stir for 40min at a speed of 2000r / min, and adjust the pH with 10% acetic acid To 4, stir with a magnetic stirrer for 30min, the speed is 2000r / min, cool the system to 1°C, and add 10% sodium hydroxide solution in the low temperature environment until the pH is 10, the stirring speed of the stirrer is 2000r / min, and the stirring time is 20min. , return to room temperature, add 25% glutaraldehyde and stir for 3 hours and tannic acid for 4 hours, and put it into a drier for 12 hours after the stirring is completed.
[0037] Then carry out the preparation of silk fibroin hollow fiber 1: boil the waste silk in 500g / l sodium carbonate solutio...
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Abstract
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