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Diol-type ginsenoside nanoemulsion with skin aging prevention function and preparation method thereof

A ginsenoside and glycol-type technology, which is used in skin care preparations, medical preparations containing active ingredients, skin diseases, etc. and other problems, to achieve the effect of simple preparation process, improving anti-skin aging function and increasing affinity

Inactive Publication Date: 2019-01-18
YANBIAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, diol-type ginsenosides have high polarity, poor fat solubility, and are not easy to penetrate the skin, so they pose a big problem for skin medication.

Method used

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  • Diol-type ginsenoside nanoemulsion with skin aging prevention function and preparation method thereof
  • Diol-type ginsenoside nanoemulsion with skin aging prevention function and preparation method thereof
  • Diol-type ginsenoside nanoemulsion with skin aging prevention function and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] The diol type ginsenoside extract is prepared according to the following method:

[0037] (1) Combine ginseng coarse powder with Ca(OH) of pH=13 2 The aqueous solution is mixed according to the ratio of solid to liquid = 1:10 (g:mL), extracted under the conditions of extraction temperature of 20°C, ultrasonic extraction power of 160w, and extraction time of 20min. After the extraction is completed, the drug residue is filtered to obtain ginseng Saponin extract: filter the extract, concentrate the filtrate to an extract, add 80% ethanol to dissolve, filter to obtain a ginsenoside filtrate, concentrate the ginsenoside filtrate to remove ethanol, add distilled water to dissolve, and obtain a ginsenoside aqueous solution;

[0038] (2) The macroporous adsorption resin (D101, Sinopharm Chemical Reagent Co., Ltd.) was put into the separation column, and the column was washed with water until the macroporous adsorption resin had no alcohol smell, and the ginsenoside aqueous sol...

Embodiment 2

[0045] The raw material of the diol-type ginsenoside extract prepared in Example 1 is used to prepare diol-type ginsenoside nanoemulsion, and the preparation method is as follows:

[0046] (1) Span 80 and 1,2-propanediol are mixed at a mass ratio of 2:1 to obtain a mixed emulsifier, and isopropyl palmitate (ie, the oil phase) is mixed with the mixed emulsifier at a mass ratio of 7.5:2.5. Under the heating condition of ℃, use a magnetic stirrer to stir and mix at a speed of 650r / min, and stir until the mixed solution is clear and transparent, and the mixed solution is obtained;

[0047] (2) The diol-type ginsenoside extract is dissolved in water to obtain the water phase, and under the heating condition of 40°C, the water phase is added dropwise to the oil phase under the condition of stirring with a magnetic stirrer at a speed of 650r / min In the mixed solution with the mixed emulsifier, when the mixed system turns from clear to cloudy, the dropwise addition is stopped to obtai...

Embodiment 3

[0050] The raw material of the diol-type ginsenoside extract prepared in Example 1 is used to prepare diol-type ginsenoside nanoemulsion, and the preparation method is as follows:

[0051] (1) Span 80 and 1,2-propanediol are mixed at a mass ratio of 2:1 to obtain a mixed emulsifier, and isopropyl myristate (ie, the oil phase) is mixed with the mixed emulsifier at a mass ratio of 7.5:2.5. Under the heating condition of 40°C, stir and mix with a magnetic stirrer at a speed of 650r / min, and stir until the mixed solution is clear and transparent to obtain a mixed solution;

[0052] (2) The diol-type ginsenoside extract is dissolved in water to obtain the water phase, and under the heating condition of 40°C, the water phase is added dropwise to the oil phase under the condition of stirring with a magnetic stirrer at a speed of 650r / min In the mixed solution with the mixed emulsifier, when the mixed system turns from clear to cloudy, the dropwise addition is stopped to obtain diol-t...

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Abstract

The invention discloses a diol-type ginsenoside nanoemulsion and a preparation method thereof and application thereof. The diol-type ginsenoside nanoemulsion comprises the following components: an aqueous phase, an oil phase and a mixed emulsifier composed of a diol-type ginsenoside extract and water; Wherein the mass ratio of the water phase to the oil phase is 5 to 8: 45; that mas ratio of the oil phase to the mixed emulsify is 7. 5-8: 2-2.5; the mass concentration of the diol-type ginsenoside extract in the water phase is 15-25%; and the content of the diol-type ginsenoside Rb1, Rb2, Rc andRd contained in the diol-type ginsenoside extract is not less than 38%. Ginsenoside nanoemulsion prepared by the method has good skin permeability and skin retention, and can promote collagen synthesis and inhibit collagenase activity, so as to achieve the function of anti-aging skin.

Description

technical field [0001] The invention relates to a nanoemulsion and its preparation method and application, in particular to diol-type ginsenoside nanoemulsion with anti-skin aging function and its preparation method. Background technique [0002] Ginseng is a perennial herb of Araliaceae (Panax ginseng, C.A.Mey.), containing amino acids, vitamins, polysaccharides, ginseng volatile oil, inorganic elements, alkaloids, peptides, fats, saponins, organic acids, flavonoids, sterols, Lignin, enzymes and other chemical components, among which ginsenoside is the main active component of ginseng. According to the difference of ginsenosides, ginsenosides are divided into oleanolic acid saponins, protopanaxatriol saponins and protopanaxadiol saponins. Diol-type ginsenosides have very significant curative effects in anti-cancer, anti-aging, replenishing vitality, enhancing body resistance, and improving memory. In recent years, due to the significant anti-aging effects of diol-type gin...

Claims

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Application Information

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IPC IPC(8): A61K8/06A61K8/63A61K9/107A61K31/704A61P17/18A61Q19/00A61Q19/08
CPCA61P17/18A61Q19/00A61Q19/08A61K8/068A61K8/63A61K9/0014A61K9/1075A61K31/704A61K2800/805
Inventor 朴明贯叶超李丹
Owner YANBIAN UNIV
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