Biodegradable hard tissue repair composite scaffold prepared by 3D printing technology and preparation method thereof

A composite scaffold and 3D printing technology, which is applied in the field of biomedical materials, can solve problems such as unsatisfactory bone repair effects, and achieve the effects of facilitating promotion and application, increasing the degree of dispersion, and regularizing the surface

Pending Publication Date: 2019-01-25
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In calcium phosphate composite materials, the content of calcium phosphate is very important to its biological activity. The existing 3D printed calcium phosphate composite scaffolds on the market have too low calcium phosphate content, often below 30%, and the bone repair effect is not ideal.

Method used

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  • Biodegradable hard tissue repair composite scaffold prepared by 3D printing technology and preparation method thereof
  • Biodegradable hard tissue repair composite scaffold prepared by 3D printing technology and preparation method thereof
  • Biodegradable hard tissue repair composite scaffold prepared by 3D printing technology and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] A composite scaffold with a mass ratio of polylactic acid / hydroxyapatite of 6 / 4 was prepared. 1. According to the conversion of mass fraction, centrifuge a certain amount of hydroxyapatite suspension to remove the supernatant, add an appropriate amount of acetone to ultrasonically stir uniformly, centrifuge again to remove the supernatant, this process is repeated three times. The washed hydroxyapatite is added to the acetone solution so that the hydroxyapatite accounts for 10% of the total suspension mass fraction. Then, 0.2% of the total mass fraction of the composite material was added with a silane coupling agent to the acetone solution of hydroxyapatite and stirred for 12 hours. 2. According to the conversion of mass fraction, add a certain amount of polylactic acid to methylene chloride to fully dissolve it, in which the polymer accounts for 10% of the total mass of the solution system, and the polymer solution is obtained as a spare. 3. After mixing the solutions...

Embodiment 2

[0058] A composite scaffold with a mass ratio of polylactic acid / tricalcium phosphate of 6 / 4 was prepared. 1. According to the conversion of mass fraction, prepare a 10% tricalcium phosphate acetone suspension, and then add 0.2% of the total mass fraction of the composite silane coupling agent to the tricalcium phosphate acetone solution for 12 hours. 2. According to the conversion of mass fraction, add a certain amount of polylactic acid to methylene chloride to fully dissolve it, in which the polymer accounts for 10% of the total mass of the solution system, and the polymer solution is obtained as a spare. 3. After mixing the solutions obtained in 1 and 2, remove the solvent to the composite material block. 4. The material block is mechanically crushed, and then the standard wire is extruded. 5. Use an FDM printer to print out the target scaffold (complex structures such as human bone models). In this embodiment, the biodegradable polymer is polylactic acid, and the inorgan...

Embodiment 3

[0060] A composite scaffold with a mass ratio of polylactic acid / biphasic calcium phosphate (BCP) of 6 / 4 was prepared. 1. According to the conversion of mass fraction, prepare a 10% diphasic calcium phosphate acetone suspension, and then add the silane coupling agent to the diphasic calcium phosphate acetone solution for 12 hours. 2. According to the mass fraction conversion, add a certain amount of polylactic acid to the methylene chloride to fully dissolve it, and obtain a polymer solution for use. 3. After mixing the solutions obtained in 1 and 2, remove the solvent to the composite material block. 4. The material block is mechanically crushed, and then the standard wire is extruded. 5. Use an FDM printer to print out the target scaffold (complex structures such as human bone models). In this embodiment, the biodegradable polymer is polylactic acid, and the inorganic active ingredient is biphasic calcium phosphate. Biphasic calcium phosphate is a mixture of hydroxyapatite...

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Abstract

The invention discloses a biodegradable hard tissue repair composite scaffold prepared by 3D printing technology and a preparation method thereof, belonging to the field of biomedical materials. The composite scaffold combines degradable high molecular polymer and biologically active calcium phosphate together through a wet composite method, complements each other in advantages, and obtains a hardtissue repair scaffold material with excellent mechanical properties and biologically active through a 3D printing technology of melt extrusion (FDM). Silane coupling agent was used to modify the surface of calcium phosphate nano-powder, which enhanced the combination of calcium phosphate and polymer, and improved the fluidity and integrity of outgoing wire in the preparation of FDM standard wire.

Description

Technical field [0001] The invention belongs to the technical field of biomedical materials, and particularly relates to a degradable bioactive 3D printing hard tissue repair material and a preparation method thereof. technical background [0002] In my country, there are more than 15 million patients with bone defect caused by various factors such as bone trauma, bone tissue inflammation and bone tumor resection each year, and the number of patients with tooth defect and tooth defect is as high as 1 / 5-1 / 3 of the total population. The number of patients with bone and tooth hard tissue defects due to diseases, accidents, population aging, etc. is increasing, and the number of autologous tissues is severely limited, and the allogeneic tissues have immune rejection reactions. Artificial composite materials are used for hard tissue replacement and repair. It is of great significance. [0003] Calcium phosphate (Ga-P) bioceramics have excellent biocompatibility, good osteoconductivity ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/46A61L27/56A61L27/58B29C48/00B29C64/118B33Y10/00B33Y70/00
CPCA61L27/46A61L27/56A61L27/58B29C64/118B33Y10/00B33Y70/00
Inventor 张勃庆王科锋樊渝江周长春孙勇张兴栋
Owner SICHUAN UNIV
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