Unlock instant, AI-driven research and patent intelligence for your innovation.

A kind of polyacrylic acid resin enteric coating material and preparation method thereof

A technology of enteric coating material and polyacrylic acid resin, which is applied in the field of polyacrylic acid resin enteric coating material and its preparation, can solve problems such as unreasonable formula composition and production process, large pH value restriction, troublesome users, etc. , to achieve the effect of suitable promotion, promotion of absorption and digestion, and improvement of immune function

Active Publication Date: 2020-12-08
ANHUI HUANGSHAN CAPSULE CO LTD
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since polyacrylic resins II and III are used in enteric-coated hollow capsules, the capsules tend to become brittle, and polyacrylic resins II and III dissolved at other pH values ​​cannot meet the requirements.
[0003] The formula composition and production process of the current enteric coating materials are unreasonable, resulting in a relatively restrictive pH value and a narrow dissolution range when the enteric coating materials dissolve, which brings great troubles to users

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026]A novel polyacrylic resin enteric coating material is prepared from the following raw materials in parts by weight: 40 parts of methacrylic acid, 60 parts of methyl methacrylate, 6 parts of starch, 4 parts of cellulose acetate phthalate, 2 parts of vitamin A, 2 parts of vitamin B1, 400 parts of organic solvent, 2 parts of gelatin and 18 parts of deionized water.

[0027] Among them, the organic solvent is made by mixing ethanol and acetone in the mass ratio of 1:1; The sunscreen agent is prepared by mixing titanium dioxide, zinc oxide and calcium carbonate in a mass ratio of 2:1:1; The lubricant is prepared by mixing glycerol, propylene glycol and hydroxyethyl cellulose in the mass ratio of 2:1:3.

[0028] The preparation method of the enteric coating material comprises the following steps:

[0029] (1) respectively adding methacrylic acid and methyl methacrylate into a distiller for vacuum distillation, then pouring the purified methacrylic acid and methyl methacrylate into...

Embodiment 2

[0035] A novel polyacrylic resin enteric coating material is prepared from the following raw materials in parts by weight: 43 parts of methacrylic acid, 57 parts of methyl methacrylate, 8 parts of starch, 6 parts of cellulose acetate phthalate, 3 parts of vitamin A, 3 parts of vitamin B1, 410 parts of organic solvent, 4 parts of gelatin and 20 parts of deionized water.

[0036] Among them, the organic solvent is made by mixing ethanol and acetone in the mass ratio of 1:1; The sunscreen agent is prepared by mixing titanium dioxide, zinc oxide and calcium carbonate in a mass ratio of 2:1:1; The lubricant is prepared by mixing glycerol, propylene glycol and hydroxyethyl cellulose in the mass ratio of 2:1:3.

[0037] The preparation method of the enteric coating material comprises the following steps:

[0038] (1) respectively adding methacrylic acid and methyl methacrylate into a distiller for vacuum distillation, then pouring the purified methacrylic acid and methyl methacrylate int...

Embodiment 3

[0044] A novel polyacrylic resin enteric coating material is prepared from the following raw materials in parts by weight: methacrylic acid 45 parts, methyl methacrylate 55 parts, starch 10 parts, cellulose acetate phthalate 8 parts, vitamin A 4 parts, vitamin B1：4 parts, organic solvent 420 parts, gelatin 6 parts and deionized water 22 parts.

[0045] Among them, the organic solvent is made by mixing ethanol and acetone in the mass ratio of 1:1; The sunscreen agent is prepared by mixing titanium dioxide, zinc oxide and calcium carbonate in a mass ratio of 2:1:1; The lubricant is prepared by mixing glycerol, propylene glycol and hydroxyethyl cellulose in the mass ratio of 2:1:3.

[0046] The preparation method of the enteric coating material comprises the following steps:

[0047] (1) respectively adding methacrylic acid and methyl methacrylate into a distiller for vacuum distillation, then pouring the purified methacrylic acid and methyl methacrylate into a reaction kettle, and p...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a novel polyacrylic resin enteric coating material and a preparation method thereof, and relates to the technical field of medicine production, wherein the enteric coating material is prepared from the following raw materials by weight: 40-45 parts of methacrylic acid, 55-60 parts of methyl methacrylate, 6-10 parts of starch, 4-8 parts of cellulose acetate phthalate, 2-4 parts of vitamin A, 2-4 parts of vitamin B1, 400-420 parts of an organic solvent, 2-6 parts of gelatin, 18-22 parts of deionized water, 2-4 parts of a light shading agent, and 2-4 parts of a lubricant. According to the present invention, the novel polyacrylic resin enteric coating material overcomes the deficiencies in the prior art, effectively improves the friability resistance of capsules, is elastic, has the effectively-expanded pH value range during the dissolving of enteric coating materials, is convenient to use, can promote the absorption and digestion of nutrients and drugs by human bodyby adding various nutrients, can improve the immune function, and is suitable for promotion.

Description

Technical field [0001] The invention relates to the technical field of pharmaceutical production, in particular to a novel polyacrylic resin enteric coating material and a preparation method thereof. technical background [0002] Polyacrylic resin specified in the fourth edition of Chinese Pharmacopoeia, 2015, has three kinds of coating materials: II, III and IV, of which IV is gastric coating material, and II and III are enteric coating materials. At present, polyacrylic resin II is insoluble in human stomach (gastric acid with PH 2 or so), but soluble in human small intestine (intestinal fluid with PH 6.8), while polyacrylic resin III is insoluble in human stomach and small intestine, but soluble in human colon (colonic fluid with PH 7.8). At the same time, the 2015 edition of Chinese Pharmacopoeia stipulates that enteric gelatin hollow capsules cannot disintegrate and crack in the stomach of human body within 2h, but dissolve or disintegrate in the small intestine of human bod...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/48A61K47/32
CPCA61K9/4816A61K47/32
Inventor 余超彪刘松林王邵臻
Owner ANHUI HUANGSHAN CAPSULE CO LTD
Features
  • R&D
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com