Electrochemical synthesis method of thiazole compounds

An electrochemical and thiazole technology, which is applied in the field of thiazole compound preparation, can solve the problems that the synthesis of thiazole compounds has not been reported in domestic and foreign literature, the post-processing process is complicated, and the environmental pollution is serious, and the cost is low, the equipment cost is low, and the experimental operation is simple. Effect
CN109321939BActive Publication Date: 2020-08-21BEIJING UNIV OF TECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
BEIJING UNIV OF TECH
Publication Date
2020-08-21

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Abstract

The electrochemical synthesis method of thiazole compounds belongs to the technical field of thiazole compound preparation. The method is to use 2,5-dihydrothiazole as a raw material in a single-chamber electrolytic cell, use bromide and tetrachlorohydroquinone as catalysts in the electrolyte, and electrolyze without any additional supporting electrolyte and additives. Temperature 40~80℃, current density 1~5mA / cm 2 , after passing through 3.0-4.0F / mol electricity, the 1,3-thiazole compound is obtained. The method of the present invention first adopts the indirect electrolysis method of electrochemical catalysis with simple operation to synthesize 1,3-thiazole compound, and uses a single-chamber electrolytic cell, adopts constant current electrolysis and uses a graphite sheet electrode as a working electrode, avoiding the stoichiometric oxidant The use helps to achieve atom economy, greatly reduces the cost, simplifies the operation, and is more conducive to the realization of industrial production.
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Description

Technical field

[0001] The invention relates to a double-catalyzed electrochemical synthesis method of bromide and tetrachlorohydroquinone, which is used to synthesize a thiazole compound and belongs to the technical field of thiazole compound preparation. Background technique

[0002] Thiazole is an important type of five-membered aromatic heterocyclic ring. It contains nitrogen and sulfur heteroatoms. Its special structure makes it widely used in medicine, pesticides, materials, biological dyes and artificial ion receptors (Xu Baocai. Perfume) Fragrance and Cosmetics, 1995(02):34-38.). For example, the antibiotic drug cefixime, the anticancer drug dasatinib, the antiparasitic drug nitazoxanide, the anti-inflammatory drug meloxicam, and a variety of insecticide and herbicide drugs all contain thiazole rings.

[0003] Thiazole compounds are widely found in foods that people see every day. Because of their unique nut-like, vegetable-like, sulfur-like, baked food, meaty and burnt ar...

Claims

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