Conductive hydrogel for chronic wound treatment and preparation method thereof
A technology of conductive hydrogel and chronic wounds, applied in treatment, electrotherapy, conductive adhesives, etc., can solve the problems of electrical stimulation in the wound area, electrode stimulation therapy is not applicable to large-area wounds, etc., and achieves simple preparation process, Promotes rapid healing and accelerates wound healing
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0043] A kind of conductive hydrogel that is used for chronic wound treatment, its preparation method comprises the following steps:
[0044] (1) 0.0972g cetyltrimethylammonium bromide, 0.4g urea, 0.3695g 3-sulfonic acid propyl methacrylate potassium salt, 2.6g hydroxyethyl methacrylate, 0.0148g photoinitiator 2959 , 0.3030g of methyltriacetoxysilane was dissolved in 5.36g of PBS solution to form a hydrogel matrix pregel solution;
[0045] (2) Pass the prepared hydrogel matrix pregel solution through 30mW / cm 2 Irradiate under ultraviolet light for 0.5h to initiate the polymerization of acrylate monomers, then put the system in an oven at 80°C for 9h to form a matrix hydrogel containing polysilane;
[0046] (3) The prepared polysilane-containing matrix hydrogel is fully swelled in 0.5mol / L ferric chloride aqueous solution, and then placed in 0.15mol / L pyrrole ethyl acetate solution, so that the conductive polymer monomer is The interior and surface of the matrix hydrogel cont...
Embodiment 2
[0073] (1) 0.0942g tetradecyltrimethylammonium bromide, 0.3g urea, 0.3695g 3-sulfonic acid propyl methacrylate potassium salt, 2.88g hydroxypropyl methacrylate, 0.015g thermal initiator Ammonium sulfate, 0.228g trimethylphenoxysilane was dissolved in 5.36g PBS solution, and made into a hydrogel matrix pregel solution;
[0074] (2) Heat the prepared hydrogel matrix pre-gel solution to 80°C to initiate the polymerization of hydroxypropyl methacrylate, react for 3 hours, then put the system into an oven at 80°C and heat for 12 hours to form polysilane-containing matrix hydrogel;
[0075] (3) Immerse the prepared polysilane-containing matrix hydrogel in 2mol / L ammonium persulfate aqueous solution to fully swell, and then place it in 10% aniline-hydrochloric acid solution to make the conductive polymer monomer hydrate in the silane-containing matrix The inside and surface of the glue are polymerized, the reaction time is 2h, and the reaction temperature is 5°C;
[0076] (4) The p...
Embodiment 3
[0100] (1) 0.0856g dodecyltrimethylammonium bromide, 0.6g urea, 0.31g 2-acrylamido-2-methylpropanesulfonic acid potassium salt, 2.303g N-hydroxyethylacryloyl, 0.016 g thermal initiator potassium persulfate, 0.302g isobutyltriethoxysilane was dissolved in 5.36g PBS solution to make hydrogel matrix pregel solution;
[0101] (2) Heat the prepared hydrogel matrix pre-gel solution to 65°C to initiate N-hydroxyethylacryloyl polymerization, react for 4 hours, then put the system in a 90°C oven and heat for 8h to form polysilane-containing base hydrogel;
[0102] (3) Immerse the prepared polysilane-containing matrix hydrogel in 1.8mol / L potassium persulfate aqueous solution to fully swell, and then place 8% thiophene-ethanol solution to make the conductive polymer monomer in the silane-containing matrix water The interior and surface of the gel are polymerized, the reaction time is 2h, and the reaction temperature is 20°C;
[0103] (4) The product obtained in step (3) was repeatedly...
PUM
Login to View More Abstract
Description
Claims
Application Information
Login to View More