Amycolamycin as well as preparation method thereof and application thereof

A kind of Emmycladamycin, a pharmaceutical technology, applied in the field of biopharmaceuticals, can solve the problems of narrow dose range, poor tumor specificity, poor penetration, etc., and achieve the effects of low environmental pressure, simple preparation process and low cost
CN109678917AActive Publication Date: 2019-04-26NANJING UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
NANJING UNIV
Publication Date
2019-04-26

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Abstract

The invention discloses amycolamycin as well as a preparation method thereof and application thereof. The amycolamycin is from a liquid fermentation product of endophytic actinomycetes Amycolatopsis sp.HCa4 in the intestinal tract of asiatic migratory locust, and comprises amycolamycin A or amycolamycin B. According to the experimental research results, the amycolamycin has very strong antibacterial activity on methicillin-resistant staphylococcus epidermidis staphylococcus aureus, has very strong cytotoxic activity on human breast cancer cells M231, can be prepared into a novel anti-tumour lead compound, and overcomes the drug resistance defect of existing antibiotics to a certain extent.
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Description

technical field

[0001] The invention belongs to the technical field of biopharmaceuticals, and in particular relates to an emaclamycin, its preparation method and application. Background technique

[0002] Insect guts inhabit a large number of microorganisms. Early studies on insect gut microbes mostly focused on the classification and application of insect microbes. With the deepening of research, some researchers have found that there is a wide range of non-pathogenic relationships between symbiotic bacteria and insect hosts, including mutualistic symbiotic relationships, and even some microorganisms are necessary for the growth, development and reproduction of the host. Microorganisms in this special symbiotic relationship are likely to produce some new compounds with novel structures and better activities during their metabolism.

[0003] Antitumor antibiotics refer to substances with antitumor activity produced by microbial metabolism, which can be divided into: enediy...

Claims

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