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A preparation method of high-performance biomedical amorphous calcium phosphate 3D printing material

An amorphous calcium phosphate, biomedical technology, applied in chemical instruments and methods, inorganic chemistry, additive processing, etc., can solve the problems of low purity, impossibility of application, and containing many impurities, and achieve excellent mechanical and mechanical properties.

Active Publication Date: 2022-05-20
ZHONGSHAN POLYTECHNIC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Amorphous calcium phosphate prepared by dry process—the general composition is uncontrollable and contains many impurities, so it cannot be used in medicine
On the other hand, although the purity of amorphous calcium phosphate prepared by the wet process is significantly higher than that of the dry process, it is difficult to achieve a purity of 90% and above; and because it is a thermodynamically unstable substance, it will spontaneously transform during storage It is other phosphate mineral impurities, resulting in relatively low purity (for example, standing at room temperature for 1 week, the impurity content increases by 3-5%), making it difficult for the amorphous calcium phosphate prepared by the wet process to be widely used. The existing wet process The purity of the prepared amorphous calcium phosphate can be reduced to 50% after standing for one year, which has no use value at all
Therefore, it is difficult to obtain amorphous calcium phosphate with good stability is one of the most difficult technical problems in this technical field. How to prepare amorphous calcium phosphate with high stability, high purity and high mechanical and mechanical properties is an important issue in related industries at home and abroad. Urgent technical problems to be solved

Method used

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  • A preparation method of high-performance biomedical amorphous calcium phosphate 3D printing material

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Experimental program
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Effect test

Embodiment 1

[0023] Preparation of amorphous calcium phosphate 3D printing material, prepared from the following parts by mass of raw materials according to the following steps:

[0024] a, 1 part of Ce(NO 3 ) 3 , 10 parts of magnesium chloride, 10 parts of aluminum chloride are added to 500 parts of pure water and fully stirred evenly, then 1 part of sodium fluoride and 10 parts of silica sol (SiO 2 The colloid concentration is 20%), stir and heat up to 150°C and keep it warm for 2 hours, stop the reaction and discharge, filter the reaction solution and fully wash, and then fully dry the filter cake at 80°C to obtain zero-charged magnesium silicate aluminum additives;

[0025] b. After mixing calcium chloride and calcium hydrogen phosphate dihydrate according to the molar ratio of Ca:P=3:2, then add the zero-charge magnesium aluminum silicate additive prepared in step a (the amount is calcium-containing substance and phosphorus-containing substance 0.01% of the total mass) and 500 part...

Embodiment 2

[0027] Preparation of amorphous calcium phosphate 3D printing material, prepared from the following parts by mass of raw materials according to the following steps:

[0028] a. Add 2 copies of Ce 2 (SO 4 ) 3 , 3 copies of Dy(NO 3 ) 3 , 15 parts of magnesium sulfate, 15 parts of magnesium nitrate, 20 parts of aluminum sulfate, and 10 parts of aluminum nitrate were added to 500 parts of pure water and stirred well, then 2.5 parts of lithium fluoride, 2.5 parts of sodium fluorosilicate, and 18 parts of silicon Sol (SiO 2 Colloid concentration is 22%), 12 parts of silica sol (SiO 2 The colloid concentration is 25%), stir and heat up to 200°C and keep it warm for 4 hours; stop the reaction and discharge, filter the reaction solution and fully wash, and then fully dry the filter cake at 95°C to obtain zero-charged magnesium silicate aluminum additives;

[0029] b. After mixing calcium nitrate, anhydrous calcium hydrogen phosphate, calcium dihydrogen phosphate, and sodium trip...

Embodiment 3

[0031] Preparation of amorphous calcium phosphate 3D printing material, prepared from the following parts by mass of raw materials according to the following steps:

[0032] a. Mix 1 part of CeCl 3 , 1 Dy 2 (SO 4 ) 3 , 0.5 parts of DyCl 3, 5 parts of magnesium chloride, 5 parts of magnesium sulfate, 5 parts of magnesium nitrate, 5 parts of aluminum chloride, 5 parts of aluminum sulfate, and 5 parts of aluminum nitrate were added to 500 parts of pure water and fully stirred evenly, then added 1 part of sodium fluoride, 1 part lithium fluoride, 1 part sodium fluorosilicate, 5 parts silica sol (SiO 2 Colloid concentration is 20%), 5 parts of silica sol (SiO 2 Colloid concentration is 23%), 5 parts of silica sol (SiO 2 The colloid concentration is 24%), stir and heat up to 160°C and keep it warm for 3 hours, stop the reaction and discharge, filter the reaction solution and fully wash, then fully dry the filter cake at 85°C to obtain zero-charged magnesium silicate aluminum ...

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Abstract

The invention discloses a preparation method of high-performance biomedical amorphous calcium phosphate 3D printing materials. First, rare earth substances, silica sol, soluble magnesium salts, soluble aluminum salts, fluorine salts, etc. are used as raw materials, and are prepared by high-temperature hydrothermal reaction. Obtain zero-charge magnesium aluminum silicate additives, and participate in the high-temperature water phase reaction of calcium source and phosphorus source, so as to prepare amorphous calcium phosphate nanopowder material with high purity and stable performance; it will be processed by 3D printing The bone material solid finished product with excellent mechanical and mechanical properties can be obtained, and the industrial application prospect is extremely bright.

Description

【Technical field】 [0001] The invention relates to a method for preparing a high-performance biomedical amorphous calcium phosphate 3D printing material, belonging to the technical field of 3D printing material preparation. 【Background technique】 [0002] Studies have shown that most of the organisms in nature use the amorphous phase as a precursor to form minerals with special structures and different functions through complex phase transformation processes. Biomineralized materials (such as animal bones, human teeth, mollusk shells, etc.) have excellent mechanical properties, and have always been one of the hot spots in the preparation of biomimetic materials. But so far, artificially synthesized materials such as bone-like, tooth-like, and imitation shellfish have huge differences in function from the original biomineralized materials of organisms. [0003] In the biomineralization system, mainly carbonate and phosphate minerals; but because phosphate is composed of hydro...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C01B25/32B82Y40/00B33Y70/00
Inventor 聂建华王俊李吉昌李金盛江常胜余明君
Owner ZHONGSHAN POLYTECHNIC
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