31results about How to "Purity unchanged" patented technology

The invention discloses a wind tunnel helium reuse device. The device comprises a high pressure section, a membrane I, a low pressure section, a membrane II, a throat valve and a test section, which are sequentially connected along the gas flow direction to form a wind tunnel; the device further comprises a gas flow loop pipeline connected between the high pressure section and a gas storage tankfor flowing from the high pressure section to the gas storage tank and flowing from the gas storage tank to the high pressure section, and an exhaust valve, a low pressure compressor, three groups ofgas storage tanks connected in parallel and a high pressure compressor are sequentially installed on the gas flow loop pipeline in sequence. Helium with different degrees of purity is stored in the gas storage tanks respectively, and the gas storage tank with the similar purity is selected according to the purity of the helium required for the test. The wind tunnel helium reuse device disclosed bythe invention has the advantages of simplicity, high efficiency and low use cost.

The invention discloses a de-coloring method of benzoic acid heavy by-product benzyl benzoate. The de-coloring method comprises the following steps: 1) producing a benzyl benzoate crude product through reduced-pressure distillation of leftovers from production of benzoic acid through methylbenzene liquid phase air oxidation; 2) adding reactive metal and an acidic solution into the benzyl benzoate crude product for thermal insulation reaction; 3) reducing the temperature to a room temperature after the end of reaction, and filtering and removing the unreacted reactive metal; 4) performing layered treatment on a filtrate to obtain an upper oil layer; and 5) performing reduced-pressure distillation and dehydration on the oil layer, wherein an obtained remaining material is a low-color benzyl benzoate finished product. The de-coloring method disclosed by the invention is advanced in process, convenient to operate and high in yield.

A method for crystallizing L-beta-mercaptoalanine high-purity crystal is carried out by preparing L-beta-mercaptoalanine cathode electrolytic bath liquid by electrolyzing L-cystine, decompress concentrating for electrolytic bath liquid at 70-80 degree, reaching L-beta-mercaptoalanine equivalent concentration in concentrate to 6-8N, reaching hydrochloric acid equivalent concentration 1.2-2 times of L-beta-mercaptoalanine, agitating at 1-6 degree, lowering temperature to 8-12 degree, laying aside and crystallizing. The crystal grain size is coarse, uniform, transparent, net and diamond, the length is 4-5 mm, and width and thickness are 2-3 mm. It has 5 times re-crystallization and better purity.

The invention relates to novel omarigliptin salt and crystal form products of the omarigliptin salt, and belongs to the technical field of pharmaceutical chemicrystallization. Compared with existing omarigliptin crystal form products, the omarigliptin salt and the crystal form products of the omarigliptin salt have the advantages of being better in crystal form product stability and solubility, higher in dissolving rate and the like, the bioavailability of medicine can be improved, and the omarigliptin salt and the crystal form products of the omarigliptin salt are better suitable for an application of a solid preparation. The invention also relates to the omarigliptin salt, a preparing method of the crystal form products of the omarigliptin salt, a pharmaceutical composition of the omarigliptin salt and applications of the omarigliptin salt to medicine for treating type 2 diabetes mellitus.

The invention discloses an energy-saving rectification system for purifying fusel oil. The system comprises a fusel oil feeding heat exchanger (22), a methanol rectification column (2), an ethanol rectification column (6), a fusel rectification column (14), and an extractant recovery column (18), wherein a methanol rectification column bottom heat exchanger (23) is further arranged at the bottom of the methanol rectification column (2), a fusel oil feeding line (S1) passes through the fusel oil feeding heat exchanger (22) and then is introduced into the methanol rectification column (2), a bottom discharging line of the methanol rectification column (2) is taken as a feeding line of the ethanol rectification column (6), a bottom discharging line of the ethanol rectification column (6) is taken as a feeding line of the fusel oil rectification column (14), a bottom discharging line of the fusel oil rectification column (14) is taken as a feeding line of the extractant recovery column (18), a bottom discharging line (S2) of the extractant recovery column passes through the methanol rectification column bottom heat exchanger (23) at the bottom of the methanol rectification column (2) and the fusel oil feeding heat exchanger (22) in sequence for heat exchange and then is divided into two branches, one of which is introduced to the ethanol rectification column (6) and the other is introduced to the fusel rectification column (14).

The invention relates to a novel crystal form (called form B) of a latest-generation antihypertensive drug, namely, 1-[[2'-(2,5-dihydro-5-oxo-1,2,4oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-carboxylic acid (generic name: azilsartan), and a preparation method thereof. The azilsartan is found to have a polycrystalline state for the first time, and the novel crystal form is in a semi-stable state. As proved by research, a semi-stable-state product has high crystal form stability, can be preserved at the room temperature for six months, and is free from change in a powder-X diffraction pattern and constant in HPLC (High Performance Liquid Chromatography) purity. The novel crystal form which can be applied to further medicinal development is provided for the project development.

The present invention relates to folates, compositions and uses thereof; In particular, this invention describes a crystalline or amorphous compound which is a substituted or unsubstituted folate or a reduced folate, or the natural or unnatural isomers thereof, of at least one organic base, as well as compositions and uses thereof. The compounds of the invention show a long lasting stability as well as a peculiarly high water-solubility.

The invention relates to novel omarigliptin salt and crystal form products of the omarigliptin salt, and belongs to the technical field of pharmaceutical chemicrystallization. Compared with existing omarigliptin crystal form products, the omarigliptin salt and the crystal form products of the omarigliptin salt have the advantages of being better in crystal form product stability and solubility, higher in dissolving rate and the like, the bioavailability of medicine can be improved, and the omarigliptin salt and the crystal form products of the omarigliptin salt are better suitable for an application of a solid preparation. The invention also relates to the omarigliptin salt, a preparing method of the crystal form products of the omarigliptin salt, a pharmaceutical composition of the omarigliptin salt and applications of the omarigliptin salt to medicine for treating type 2 diabetes mellitus.

The invention belongs to the technical field of biology, and particularly discloses a method for increasing the yield of corn starch. The method comprises the following steps: 1) pumping corn kernelsinto a soaking tank, adding an acid solution for soaking and then performing microwave treatment; 2) adding protease into the soaking tank for enzymolysis treatment, and optionally, 3) entering a starch processing procedure. Corn starch is subjected to soaking and multi-stage separation and purification procedures so that the starch yield is increased, the industrial process is saved and the industrial energy consumption is reduced.

The invention relates to a preparation method of cefotetan. The method comprises the steps of: under an alkaline condition, reacting the starting raw material 7-MAC with chloroacetyl chloride in an organic solvent so as to obtain the intermediate CefoD-1; under nitrogen protection, adding aluminium trichloride into anisole, stirring for dissolving, and leaving the obtained solution for standby application; taking another organic solvent, into which the intermediate CefoD-1 is added under stirring, then adding the standby solution for reacting, thus obtaining the intermediate CefoD-2; reactingthe intermediate CefoD-2 with 3, 5-dithiol-4-isothiazole formic acid trisodium salt until that a sampled cefotetan tautomer is detected less than 4.0%, after the reaction conducting a post-treatment,thus obtaining cefotetan. With improved yield and reduced cost, the method of the invention, without final heating concentration, can generate products with a shallow color and almost invariant purity.

The present disclosure relates to polymorphic forms of the compound methyl (3R,6S)-6-amino-sulfonylamino-1-(thiazol-2-yl)-3-(2,3,4-trifluorophenyl)-3,5,6,7-tetrahydropyrrolo[1,2-c]pyrimidin-4-formate (compound 1). The present disclosure further relates to a pharmaceutical composition and pharmaceutical use and a preparation method of the polymorphic forms of compound 1.

The invention discloses a preparation method of high-performance biomedical amorphous calcium phosphate 3D printing materials. First, rare earth substances, silica sol, soluble magnesium salts, soluble aluminum salts, fluorine salts, etc. are used as raw materials, and are prepared by high-temperature hydrothermal reaction. Obtain zero-charge magnesium aluminum silicate additives, and participate in the high-temperature water phase reaction of calcium source and phosphorus source, so as to prepare amorphous calcium phosphate nanopowder material with high purity and stable performance; it will be processed by 3D printing The bone material solid finished product with excellent mechanical and mechanical properties can be obtained, and the industrial application prospect is extremely bright.

The invention discloses a de-coloring method of benzoic acid heavy by-product benzyl benzoate. The de-coloring method comprises the following steps: 1) producing a benzyl benzoate crude product through reduced-pressure distillation of leftovers from production of benzoic acid through methylbenzene liquid phase air oxidation; 2) adding reactive metal and an acidic solution into the benzyl benzoate crude product for thermal insulation reaction; 3) reducing the temperature to a room temperature after the end of reaction, and filtering and removing the unreacted reactive metal; 4) performing layered treatment on a filtrate to obtain an upper oil layer; and 5) performing reduced-pressure distillation and dehydration on the oil layer, wherein an obtained remaining material is a low-color benzyl benzoate finished product. The de-coloring method disclosed by the invention is advanced in process, convenient to operate and high in yield.

The invention discloses a multi-shaft common-rail pulse liquid micro-refinement apparatus. The apparatus comprises a refinement chamber, above two pipelines and a high pressure pump; the refinement chamber is provided with the above two pipelines, one ends of the pipelines are positioned outside the refinement chamber, have three-way structures, and are connected with the high pressure pump and a slurry raw material tube respectively, the slurry raw material tube is provided with a valve, the other ends of the pipelines are positioned in the refinement chamber and are provided with nozzles, the central shafts of the nozzles intersect in the refinement chamber, and the refinement chamber is provided with a material outlet. The apparatus which rapidly breaks and refines the material through utilizing the superposed energy has the characteristics of unique technology, compact structure, stable performances, strong effect, multifunction and the like. The apparatus is mainly used for the controllable refinement treatment of the material in a liquid state, and has the compounding, surface treatment and emulsification functions, and the obtained treated product has a smallest particle size reaching above 1nm nanometer level dimension, has particle size specification uniformity reaching above 80% and an improved functionality.

The invention discloses an energy-saving rectification system for purifying fusel oil. The system comprises a fusel oil feeding heat exchanger (22), a methanol rectification column (2), an ethanol rectification column (6), a fusel rectification column (14), and an extractant recovery column (18), wherein a methanol rectification column bottom heat exchanger (23) is further arranged at the bottom of the methanol rectification column (2), a fusel oil feeding line (S1) passes through the fusel oil feeding heat exchanger (22) and then is introduced into the methanol rectification column (2), a bottom discharging line of the methanol rectification column (2) is taken as a feeding line of the ethanol rectification column (6), a bottom discharging line of the ethanol rectification column (6) is taken as a feeding line of the fusel oil rectification column (14), a bottom discharging line of the fusel oil rectification column (14) is taken as a feeding line of the extractant recovery column (18), a bottom discharging line (S2) of the extractant recovery column passes through the methanol rectification column bottom heat exchanger (23) at the bottom of the methanol rectification column (2) and the fusel oil feeding heat exchanger (22) in sequence for heat exchange and then is divided into two branches, one of which is introduced to the ethanol rectification column (6) and the other is introduced to the fusel rectification column (14).

The invention discloses a process method for preparing alpha-aluminum hydride by sodium borohydride catalysis. The method comprises a step (1) of preparing a catalyst solution; a step (2) of preparation of alpha-aluminum hydride; and a step (3) of product aftertreatment. The process method for preparing alpha-aluminum hydride by sodium borohydride catalysis can be implemented at a low temperature and normal pressure, and is suitable for industrial production. The obtained alpha-aluminum hydride is single in crystal form, the single-batch conversion rate is 86.5% or above, the purity reaches 98%, the thermal stability is high, and the alpha-aluminum hydride is favorable for being applied to fields of energetic materials, propellants and fuel cells and the like.

The invention discloses an oxazolidinone type antibacterial medicine sodium salt crystal form B, and a preparation method and application thereof, and belongs to the field of medicine chemical industry. The crystal form B comprises the following 2 theta reflection angle measuring characteristic peaks in an X-ray powder diffraction spectrum: 11.4+ / -0.2 degrees, 15.3+ / -0.2 degrees, 16.6+ / -0.2 degrees, 17.9+ / -0.2 degrees, 20.7+ / -0.2 degrees and 24.4+ / -0.2 degrees. The crystal form has the advantages that better stability is realized; the organic solvent residue is lower; the moisture absorption is avoided; better flowability and preparation processing performance are realized; important application significance is realized in the antibiotic medicine preparation.