Composite woody oil fat emulsion preparation with invigorating stomach function and its preparation method and application

A technology of emulsion preparation and wood balsam, which is applied in the directions of oil/fat/wax inactive ingredients, medical preparations containing active ingredients, and pharmaceutical formulations, etc. , the effect of excellent storage stability

Active Publication Date: 2021-12-03
广东现代汉方科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no compound woody oil and fat emulsion preparation stomachic products made of woody oil, corn germ oil, wheat germ oil, coix seed oil, and imperial rice oil

Method used

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  • Composite woody oil fat emulsion preparation with invigorating stomach function and its preparation method and application
  • Composite woody oil fat emulsion preparation with invigorating stomach function and its preparation method and application
  • Composite woody oil fat emulsion preparation with invigorating stomach function and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] Embodiment 1 compound woody oil fat emulsion injection preparation one

[0059] (1) Composition is as shown in table 1:

[0060] Table 1

[0061]

[0062]

[0063] (2) Preparation method

[0064] 1) Add 45g of wheat germ oil (both for injection) to 40g of corn germ oil in a water bath at about 55°C and nitrogen protection, mix well, then add 15g of woody oil, stir well, add 20g of soybean lecithin and 100mg of vitamin E. Stir until the phospholipid dissolves to form a uniform mixed phase, and cool to room temperature to obtain an oil phase.

[0065] 2) Put 800mL of water for injection in a container under the protection of a water bath at about 55°C and nitrogen, add 40g of povidone, 22g of glycerin for injection and 15g of soybean lecithin, shear and stir to dissolve and mix evenly, and cool to room temperature to obtain an aqueous phase.

[0066] 3) Under stirring conditions, slowly add the oil phase to the water phase, while shearing and stirring for about ...

Embodiment 2

[0070] Example 2 Composite woody oil fat emulsion injection preparation two

[0071] (1) Composition is as shown in table 2:

[0072] Table 2

[0073]

[0074]

[0075] (2) Preparation method

[0076] 1) Add 35g of wheat germ oil (both for injection) to 50g of coix seed oil in a water bath at about 56°C and nitrogen protection, mix well, then add 15g of woody oil, stir until uniform, add 20g of egg yolk lecithin and 100mg Vitamin C, stirred until the phospholipids dissolve to form a uniform mixed phase, cooled to room temperature to obtain an oil phase.

[0077] 2) Put 800mL of water for injection in a container at about 56°C under nitrogen protection, add 30g of polyethylene glycol, 22g of glycerin for injection and 15g of egg yolk lecithin, shear and stir to dissolve and mix evenly, and cool to room temperature to obtain an aqueous phase.

[0078] 3) Under stirring conditions, slowly add the oil phase to the water phase, while shearing and stirring for about 20 min...

Embodiment 3

[0082] Example 3 Composite woody oil fat emulsion injection preparation three

[0083] (1) Composition is as shown in table 3:

[0084] table 3

[0085]

[0086]

[0087] (2) Preparation method

[0088] 1) In a water bath at about 58°C and under nitrogen protection, add 20g of royal rice oil and 25g of wheat germ oil (both for injection) to 35g of coix seed oil, mix well, then add 20g of wood fragrance oil, stir until uniform, and put in 20g Egg yolk lecithin and 100 mg of vitamin E were stirred until the phospholipids were dissolved to form a uniform mixed phase, cooled to room temperature to obtain an oil phase.

[0089] 2) Put 800mL of water for injection in a container under the protection of a water bath at about 58°C and nitrogen, add 25g of povidone, 22g of glycerin for injection and 15g of egg yolk lecithin, shear and stir to dissolve and mix evenly, and cool to room temperature to obtain an aqueous phase.

[0090] 3) Under stirring conditions, slowly add the...

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Abstract

The invention discloses a compound woody oil fat emulsion preparation with the effect of invigorating the stomach, a preparation method and application thereof. The fat emulsion preparation comprises woody oil, vegetable oil, emulsifier, solubilizer, antioxidant and isotonic regulator. The compound woody oil fat emulsion preparation is a reasonable combination of volatile woody oil and vegetable oil, and the obtained preparation has high dispersibility and excellent storage stability, and overcomes the defect that active ingredients in existing woody oil products are volatile, The bioavailability and drug efficacy are greatly improved, and it has obvious inhibitory effect on the amount of gastric juice, total acidity and pepsin activity in rats with pyloric-ligated gastric ulcer, can significantly increase the NO content in rat gastric juice, increase the SOD activity in gastric tissue and Reduce MDA content, strengthen stomach and anti-gastric ulcer effect is obviously better than single woody oil extract.

Description

technical field [0001] The invention relates to a preparation, in particular to a compound woody oil fat emulsion preparation with the effect of invigorating the stomach, its preparation method and application. Background technique [0002] Muxiang is the dried root of Aucklandia lappa Decne, a plant of Compositae. It is a species included in the Chinese Pharmacopoeia. Woody incense has the functions of promoting qi and relieving pain, invigorating the spleen and eliminating food. It is mainly used to treat chest and hypochondrium, abdominal distension and pain, heavy diarrhea after diarrhea, indigestion persists, and lack of appetite. Modern pharmacological and pharmacological studies have shown that woody wood has the following effects: 1) digestive system, woody wood can promote gastric emptying and intestinal propulsion in rats, and directly protect gastric mucosa, prevent gastric ulcers, and also have Choleretic, anti-diarrhea, anti-inflammatory and inhibiting Helicoba...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/107A61K36/8994A61K36/899A61K47/44A61P1/00A61P1/04
Inventor 李肇联王兴林刘少勇郑泽苗王美静
Owner 广东现代汉方科技有限公司
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