A controllable biodegradable copolymer with basic copolymerization center

Abstract

The invention provides a controllable biodegradable copolymer with an alkaline copolymerization center; a copolymer prepared from lactide, caprolactone and alkaline copolymerization centers with different optical rotation ratios, the copolymer can improve the The pH drop caused by the degradation of PLA improves the biocompatibility of the copolymer. The biodegradable copolymer provided by the invention has excellent mechanical strength, biocompatibility and pH adjustment function, and can be widely used in carriers or devices used in the field of tissue engineering, especially in the preparation of nerve conduits.

Description

technical field

[0001] The invention belongs to the field of polymer materials, and relates to a controllable biodegradable copolymer with a basic copolymerization center and its application in the preparation of carriers or devices used in the field of tissue engineering. Background technique

[0002] According to the source, biodegradable polymers can be divided into two categories: natural and synthetic. Natural degradable polymers include chitosan, chitin and their derivatives, etc.; synthetic degradable polymers are divided into two categories: artificial synthesis and bacterial synthesis. . Degradable polymers synthesized by bacteria include polyhydroxyalkanol esters and polyB 2 Glucose esters, etc., synthetic degradable polymers include aliphatic polyesters, polyamino acids, and polyphosphazenes, among which polyesters are currently the only type of biodegradable materials approved by the US FDA for use in the biomedical field. The more commonly used ones are: polyl...

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