A composite collagen dressing for repairing difficult-to-heal wounds and its preparation method

A technology for wound repair and collagen, which is applied in medical science, absorbent pads, bandages, etc., can solve the problems of long action time and achieve the effects of prolonging the degradation time, simple and controllable preparation process, and increasing the application range

Active Publication Date: 2021-10-22
BEIJING QINGYUAN WEIYE BIO TISSUE ENG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] For the repair of difficult-to-heal wounds, although a single component of collagen can play a repair role, but the action time is too long

Method used

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  • A composite collagen dressing for repairing difficult-to-heal wounds and its preparation method
  • A composite collagen dressing for repairing difficult-to-heal wounds and its preparation method
  • A composite collagen dressing for repairing difficult-to-heal wounds and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

experiment example 3

[0037] The rat material of Experimental Example 3 is provided by the Experimental Animal Center of Tianjin Medical University. The first group of embodiments, the composite collagen dressing for refractory wound repair of the present invention

[0038] This group of examples provides a composite collagen dressing for the repair of difficult-to-heal wounds. The "difficult-to-heal wounds" in this article refer to wounds with poor self-healing ability and healing time of more than 2 months, generally including chronic difficult-to-heal wounds and traumatic wounds. Difficult to heal wounds.

[0039] All embodiments of this group all possess following common features:

[0040] The weight ratio of type I collagen to type III collagen in the composite collagen dressing is 99.99-85:0.01-15;

[0041] Type III collagen can be as low as 0.01. Although such a small amount, it plays a key role in the composite collagen auxiliary material of the present invention. The inventor unexpectedly...

experiment example 1

[0058] The preparation technology of experimental example 1 layered film

[0059] (1) Collagen types I and III (w / w:99.3:0.7) with a certain mass concentration were homogenized and spread in a container and placed in an ultra-low temperature refrigerator at -80°C for 24 hours to form an outer homogenate film;

[0060] (2) Spread the homogenate of type I and III collagen (w / w97:3) with a certain mass concentration on the outer homogenate membrane and place it in -80°C for 24 hours to form a contact layer homogenate membrane. Dry in a freezer vacuum dryer at -50°C for 24 hours to form a layered film.

[0061] The content of type III collagen in the homogenized membrane of the outer layer is 0.01-1%, and the content of collagen III in the homogenized membrane of the contact layer is 1-15%.

experiment example 2

[0062] The preparation technology of experimental example 2 fiber film

[0063] (1) Weigh type I collagen and type III collagen, disperse them in distilled water according to the ratio of 93:7 (W / W), and mix them with a high-speed mixer to prepare a homogenate with a certain mass concentration, and add a cross-linking agent to cross-link Prepared into collagen copolymer;

[0064] (2) Dissolving the cross-linked copolymer in a hexafluoroisopropanol solution, placing the solution in a liquid storage tube of a high-voltage electrospinning machine, and making a chemically composite collagen fiber membrane by electrospinning.

[0065] The preparation process of the sponge-like material includes dispersion-prefreeze molding-freeze-drying, and the general method for preparing sponges in the art can be adopted. Different collagens are mixed in proportion, homogenized, defoamed, pre-frozen in a mold, and freeze-dried.

[0066] Application of experimental example 3 composite collagen ...

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Abstract

The invention discloses a composite collagen dressing for repairing difficult-to-heal wounds and a preparation method thereof, which comprises dispersing type I collagen and type III collagen in a solvent in proportion, homogenizing, compounding, and reshaping; The components involved in the present invention are selected from multi-component collagen materials of different types and contents, which can give full play to the characteristics of each collagen component, speed up the repair of wounds, and improve the quality of wound healing.

Description

technical field [0001] The invention belongs to the field of biomaterials, in particular to a composite collagen dressing for repairing difficult-to-heal wounds and a preparation method thereof. Background technique [0002] The prevalence of various chronic diseases is increasing year by year, resulting in a high incidence of related chronic wounds such as pressure sores, diabetic feet, and venous lower extremity ulcers. The common clinical wounds have changed from acute wounds to chronic wounds, and chronic wounds caused by various traumas, burns, scalds, non-healing postoperative wounds, decubitus ulcers, sugar rotten feet, and ecthyma (commonly known as rotten legs) have leapt to the top of the list. rate first. [0003] Diabetes is a frequently-occurring and common disease with high morbidity, great harm, and spread all over the world. It is one of the civilized diseases of modern life and has been listed as one of the three difficult diseases by WHO (World Health Orga...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/32A61L15/62
CPCA61L15/325A61L15/62
Inventor 李志宏郭雅楠王微
Owner BEIJING QINGYUAN WEIYE BIO TISSUE ENG
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