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Plastic DBM (decalcified bone matrix) bone induced self-curing bone grafting material and preparation method thereof

An osteoinductive and self-curing technology, which is applied in the fields of pharmaceutical formulation, medical science, tissue regeneration, etc., can solve the problems of mechanical properties and degradation performance, lack of mechanical support, and self-curing, etc., to achieve rapid bone formation and widen the raw material source, the effect of good anti-collapse performance

Inactive Publication Date: 2019-07-09
湖北联结生物材料有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This type of product must rely on medical grade α-calcium sulfate hemihydrate, otherwise its mechanical properties and degradation properties will be affected to a certain extent. At the same time, β-TCP cannot be self-cured, and only serves to slow down the degradation rate and provide calcium source phosphorus. Therefore, after the calcium sulfate is degraded and the bone defect has not completely healed, there is no mechanical support.

Method used

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  • Plastic DBM (decalcified bone matrix) bone induced self-curing bone grafting material and preparation method thereof
  • Plastic DBM (decalcified bone matrix) bone induced self-curing bone grafting material and preparation method thereof
  • Plastic DBM (decalcified bone matrix) bone induced self-curing bone grafting material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] A plastic DBM osteoinductive self-curing bone graft material (injection type), prepared by the following method: 20 parts of β-calcium sulfate hemihydrate, 10 parts of calcium sulfate dihydrate, 30 parts of α-TCP, carboxymethyl fiber 5 parts of plain sodium, mechanically milled for 20 minutes to make the powder evenly mixed, then add 2wt% disodium hydrogen phosphate solution according to the solid-to-liquid ratio of 1:1, stir into mud, then add 35 parts of DBM, the DBM bone meal is the same Allogeneic bone powder with a size of 100 μm to 900 μm, and continue to stir for 1 min to make the DBM disperse evenly. Transfer the sample to a syringe, inject it into physiological saline, and leave it for a day without collapsing; inject it into a mold, and then put it into a constant temperature and humidity box (temperature 37°C, humidity 98%) to cure and shape. After curing for 3 days, the compressive strength It is 3.2MPa.

Embodiment 2

[0032] A plastic DBM osteoinductive self-curing bone graft material (face clay type), prepared by the following method: 39 parts of α-calcium sulfate hemihydrate, 1 part of calcium sulfate dihydrate, 20 parts of β-TCP, hydroxypropyl 5 parts of methylcellulose, mechanically milled for 15 minutes to mix the powder evenly, then add water for injection according to the solid-to-liquid ratio of 1:0.9, stir into a slurry, then add 35 parts of DBM, the DBM bone powder is allogeneic bone powder , with a size of 100 μm to 900 μm, continue to stir for 1 min to disperse the DBM evenly. Transfer the sample to a syringe, inject it into physiological saline, and leave it for a day without collapsing; inject it into a mold, and then put it into a constant temperature and humidity box (temperature 37°C, humidity 98%) to cure and shape. After curing for 3 days, the compressive strength is 3.0 MPa.

Embodiment 3

[0034] A plastic DBM osteoinductive self-curing bone graft material (preformed), prepared by the following method: 20 parts of β-calcium sulfate hemihydrate, 10 parts of calcium sulfate dihydrate, 30 parts of α-TCP, carboxymethyl fiber 5 parts of plain sodium, mechanically milled for 20 minutes to make the powder evenly mixed, then add 2wt% disodium hydrogen phosphate solution according to the solid-to-liquid ratio of 1:1, stir into mud, then add 35 parts of DBM, the DBM bone meal is the same Allogeneic bone powder with a size of 100 μm to 900 μm, and continue to stir for 1 min to make the DBM disperse evenly. The sample was filled into the mold, cured and molded in a constant temperature and humidity box (temperature 37°C, humidity 98%), and after curing for 3 days, it was freeze-dried to obtain a preformed product with a compressive strength of 3.9 MPa.

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Abstract

The invention belongs to the field of biomedical materials and particularly relates to a plastic DMB (decalcified bone matrix) bone induced self-curing bone grafting material and a preparation methodthereof. The bone grafting material is composed of a powder and a curing solution in the proportion of 1:0.8-1.5, and the powder is prepared from, by weight, 20%-40% of calcium sulfate, 5%-40% of calcium phosphate, 2%-15% of an organic addition agent and 20%-60% of DBM bone powder; the calcium sulfate is calcium sulfate semi-hydrate and calcium sulphate dihydrate; the calcium phosphate is alpha-tricalcium phosphate, beta-tricalcium phosphate or hydroxyapatite. The bone grafting material has excellent bone induction and bone conductivity and anti-collapse performance, can solidify in vivo, fixDBM in bone defect area, slow degradation of DBM and continuously release growth factor; different dosage forms can be prepared by controlling the liquid-solid ratio, which can meet the needs of patients.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a plastic DBM osteoinductive self-curing bone graft material and a preparation method thereof. Background technique [0002] Worldwide, bone transplantation is the second most common tissue transplant after blood transfusion. At present, the three materials used to treat bone defects are mainly autologous bone, allogeneic bone and artificial bone. Among them, autogenous bone has always been used as the gold standard for bone transplantation, and the treatment effect is the best. However, the operation process is relatively complicated, and bone needs to be taken from the patient's body, resulting in postoperative pain and complications. Allogeneic bone, such as decalcified bone matrix (DBM), will not cause additional pain to people, and has good osteoinductivity and promotes the growth of osteoblasts. However, the source of materials is insufficient, and it is dif...

Claims

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Application Information

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IPC IPC(8): A61L27/42A61L27/36A61L27/56A61L27/58
CPCA61L27/3608A61L27/365A61L27/425A61L27/56A61L27/58A61L2400/06A61L2430/02
Inventor 张旗张铁
Owner 湖北联结生物材料有限公司
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