Unlock instant, AI-driven research and patent intelligence for your innovation.

Preparation method of highly stable and water-soluble industrial hemp CBD microcapsule

An industrial hemp, water-soluble technology, applied in microcapsules, skin care preparations, medical preparations containing active ingredients, etc., can solve problems such as deficiencies, hinder the influence of THC on the human nervous system, etc. Improved bioavailability and effect, long-lasting effect

Inactive Publication Date: 2019-07-19
西宝生物科技(上海)股份有限公司
View PDF2 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, developed countries such as Israel, the United States, and the United Kingdom have used it as a raw material and developed a variety of special effects drugs and cosmetics. CBD is a non-addictive ingredient in industrial hemp (THC is less than 0.3%), which can hinder THC from affecting human nerves. Systemic effects, and have anti-spasmodic, anti-rheumatic arthritis, anti-anxiety and other pharmacological activities, but phenolic substances are easily oxidized by oxygen in the air, basically insoluble in water, their stability and release in product use, There are deficiencies

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method of highly stable and water-soluble industrial hemp CBD microcapsule
  • Preparation method of highly stable and water-soluble industrial hemp CBD microcapsule
  • Preparation method of highly stable and water-soluble industrial hemp CBD microcapsule

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0023] see Figure 1-2 , the present invention provides a technical solution: a preparation method of highly stable water-soluble industrial hemp CBD microcapsules, comprising the following steps:

[0024] 1) Weigh 300g of industrial hemp CBD and dissolve it in 380ml of absolute ethanol to obtain A solution;

[0025] 2) Weigh 1250g of cyclodextrin and 70.00g of guar gum, and add them into 13000ml of deionized water to obtain a saturated solution of B;

[0026] 3) Weigh 250g of natural gum arabic and add it into 13000ml of deionized water to obtain a saturated solution of C;

[0027] 4) Add solution A and pour it into a high-pressure ball mill. The high-pressure gas in the high-pressure ball mill and the ball milling beads will squeeze and break the wall material, and ball mill for 30-60 minutes. Collect the fine liquid in the mixture and pour it into the collector at the same time. Reserve 1;

[0028] 5) Add the spare 1 solution to the colloid mill, start the colloid mill cy...

Embodiment 1

[0039]Weigh 100mL of sterile water, add 5g of stable water-soluble industrial hemp CBD microcapsules while stirring, mix evenly, add 8g of inulin and 0.2g of potassium sorbate, after mixing and hot-melting, add deionized water to constant volume, Stir, finely filter, add 0.02g of essence, fill and seal, and you can get the water-soluble industrial hemp CBD microcapsule liquid drink.

Embodiment 2

[0041] Women have a great demand for cosmetics. Base makeup: liquid foundation, powder cake, loose powder Eyes: eye shadow, eyeliner, eyelash curler, mascara, lips, lip balm, lip concealer, lipstick or lip gloss, face: gills Red, highlighter, repairing powder, etc., and every time cosmetics are used, the cosmetics use microencapsulation technology to surround a layer of hydrophilic semi-permeable membranes with enzymes, coenzymes, proteins and other biological macromolecules or animal and plant cells. In the beaded microcapsules, when women apply on the face, due to the addition of water-soluble industrial hemp CBD microcapsules, the spherical microcapsules need to be cleaned when they are in contact with the skin. The water in contact with the spherical microcapsules on the cosmetics will quickly absorb water, and will expand to release the coated cannabidiol and spices. The application in cosmetics highlights the original effect and the slow-release effect after microencapsul...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Solubilityaaaaaaaaaa
Login to View More

Abstract

The invention discloses a preparation method of a highly stable and water-soluble industrial hemp CBD microcapsule. The preparation method includes the following steps: pouring an industrial hemp CBDcomponent into a high-pressure ball mill according to a mass-to-volume ratio of CBD to 40% ethanol being 1:5, conducting ball milling for 30-60 min, collecting fine liquid in the mixture, and pouringthe mixture into a collector at the same time as a material 1 for standby; preparing a saturated solution according to a mass ratio of industrial hemp CBD to capsule being 1:5, conducting filtering, taking the solution as a solution 2 for standby; adding the saturated aqueous solution 2 for standby to a grinding device to obtain an inclusion product; pumping the inclusion product into a spray drying device when the spray drying device is preheated to 80 DEG C, rotating the spiral airflow in the spray drying device, synchronously evaporating water, and conducting continuous spinning to form a spherical microcapsule. The preparation method can significantly improve the solubility and stability of the active ingredient, namely the industrial hemp CBD, by performing specific micro micelle processing on the capsule walls, thereby improving the bioavailability and action effect, improving the anti-oxidation ability and making the active ingredient last longer and more stable.

Description

technical field [0001] The invention relates to the technical field of utilization of industrial hemp CBD, in particular to a preparation method of highly stable water-soluble industrial hemp CBD microcapsules. Background technique [0002] Industrial hemp is a biological resource with unique characteristics and outstanding comparative advantages. Industrial hemp is a kind of non-toxic industrial raw material product with high economic value. Industrial hemp fiber and hemp seeds and their flowers, leaves, roots and stems A series of product research and development and industrialization comprehensive development for raw materials have been carried out on the basis of industrialized production of the main products of industrial hemp primary processing, hemp fiber, core fiber, hemp seed oil, seed cypress protein, and medicinal standardized extract. Through deep processing and utilization, more than 25,000 kinds of products have been derived, including human clothing, food, hou...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K9/50A61K31/05A61K8/34A61K8/11A61Q19/10A23L2/56A23L33/105A23L2/44A23P10/30
CPCA23L2/44A23L2/56A23V2002/00A61K8/11A61K8/347A61K9/5036A61K9/5042A61K9/5057A61K31/05A61K2800/412A61Q19/10A23L33/105A23P10/30A23V2200/02A23V2200/15A23V2200/30A23V2250/2132A23V2250/082A23V2250/5112A23V2250/506A23V2250/5028A23V2300/10
Inventor 张广华陈立军刘云
Owner 西宝生物科技(上海)股份有限公司