Method for preparing dihydroartemisinin crude drug by single process
A technology of dihydroartemisinin and raw materials, which is applied in the fields of resisting vector-borne diseases and organic chemistry, etc., can solve the problem that the raw materials of dihydroartemisinin cannot be produced, cannot meet the environmental requirements of raw materials, and cannot achieve dust-free Aseptic operation and other issues, to achieve the effect of reducing the difficulty of recycling, reducing the amount of use, and reducing the difficulty of separation
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Embodiment 1
[0047] A method for preparing a dihydroartemisinin bulk drug in a single flow process, comprising the steps of:
[0048] S1. Dissolving 100kg artemisinin in 600L toluene;
[0049] S2. Add 50L of an aqueous solution containing 0.5kg of benzyltriethylammonium chloride, cool down to -10°C, and start adding sodium borohydride reducing agent in batches under nitrogen protection, totaling 16kg, and control the temperature not to exceed 0°C. Continue to react for 5 hours, monitor with thin-layer chromatography, when the artemisinin spots disappear completely, the reaction is considered complete;
[0050] S3. Regulate the pH value of the reaction system obtained in step S2 to 7 with a mass concentration of 25% acetic acid solution, and control the temperature of the system during the adjustment process to be 0-5°C; this process is completed in an automatic interlock device, and the automatic interlock The device includes a temperature sensor, a pH sensor, a sampling controller, a sti...
Embodiment 2
[0055] A method for preparing a dihydroartemisinin bulk drug in a single flow process, comprising the steps of:
[0056] S1. Dissolving 100kg artemisinin in 600L dichloromethane;
[0057] S2. Add 50L of an aqueous solution containing 0.5kg of benzyltriethylammonium chloride, cool down to -10°C, and start adding sodium borohydride reducing agent in batches under nitrogen protection, totaling 16kg, and control the temperature not to exceed 0°C. Continue to react for 5 hours, monitor with thin-layer chromatography, when the artemisinin spots disappear completely, the reaction is considered complete;
[0058] S3. Adjust the pH value of the reaction system obtained in step S2 to 7 with a mass concentration of 25% acetic acid solution, and control the temperature of the system during the adjustment process to be 0-5 ° C; the above operation is completed using the same automatic interlocking device as in Example 1; add water After stirring, separate the liquids, extract the aqueous ...
Embodiment 3
[0062] A method for preparing a dihydroartemisinin bulk drug in a single flow process, comprising the steps of:
[0063] S1. Dissolving 100kg artemisinin in 600L toluene;
[0064] S2. Add 50L of an aqueous solution containing 0.5kg of benzyltriethylammonium chloride, cool down to -10°C, and start adding sodium borohydride reducing agent in batches under nitrogen protection, totaling 16kg, and control the temperature not to exceed 0°C. Continue to react for 5 hours, monitor with thin-layer chromatography, when the artemisinin spots disappear completely, the reaction is considered complete;
[0065] S3. Adjust the pH value of the reaction system obtained in step S2 to 7 with a mass concentration of 25% acetic acid solution, and control the temperature of the system during the adjustment process to be 30° C.; the above operation is completed with the automatic interlocking device in Example 1; after adding water and stirring Separating the liquid, extracting the aqueous phase ob...
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