Preparation method of nano copper sulfide applied to tumor photo-thermal therapy

A technology of photothermal treatment and copper sulfide, which is applied in the field of nanomaterials and photothermal conversion, can solve the problems of uneven nano-copper sulfide morphology, cumbersome synthesis process, unfriendly environment, etc., and achieve low requirements for reaction equipment, photothermal Good effect and uniform appearance

Inactive Publication Date: 2019-08-23
SHANGHAI INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The synthesis process is relatively cumbersome, and the use of organic solvents is involved in the reaction process, which is not environmentally friendly, and the final nano-copper sulfide has problems of uneven morphology and poor hydrophilicity.
Chinese patent CN201410617810 introduces a kind of nano-copper sulfide particles for photocatalysis, which requires not only high temperature reaction, but also the use of ether, 1-(2-methoxy)imidazole hydrochloride and iodoethyl phosphoric acid Organic substances such as diethyl ester have great environmental pollution, and the preparation time is long and the cost is high

Method used

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  • Preparation method of nano copper sulfide applied to tumor photo-thermal therapy
  • Preparation method of nano copper sulfide applied to tumor photo-thermal therapy
  • Preparation method of nano copper sulfide applied to tumor photo-thermal therapy

Examples

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Embodiment 1

[0029] A preparation method for nano-copper sulfide applied to tumor photothermal therapy, the specific steps are: take 3g of polyethylene glycol (average molecular weight 500), put 0.8g of copper chloride dihydrate into a 100mL beaker, add 50 mL of deionized water was stirred and dissolved to obtain a copper chloride solution. Take by weighing 12g sodium sulfide nonahydrate and dissolve it in 200mL of deionized water to obtain an aqueous solution of sodium sulfide, use a peristaltic pump to add 20mL of sodium sulfide solution to the copper chloride solution under magnetic stirring (200r / min) within 2 hours, add dropwise After completion, continue to stir the reaction for half an hour. Then put the beaker into an oven at 45°C after being sealed with plastic wrap, take it out after 4 hours of insulation, and centrifuge, wash the precipitate with ethanol three times, centrifuge, and dry the gained solid overnight in an oven at 50°C ( 12 hours), obtain black massive nano-copper ...

Embodiment 2

[0033] A preparation method for nano-copper sulfide applied to tumor photothermal therapy, the specific steps are: take 5g of polyethylene glycol (average molecular weight 500), put 0.8g of copper chloride dihydrate into a 100mL beaker, add 50 mL of deionized water was stirred and dissolved to obtain a copper chloride solution. Take by weighing 12g sodium sulfide nonahydrate and dissolve it in 200mL of deionized water to obtain an aqueous solution of sodium sulfide, use a peristaltic pump to add 20mL of sodium sulfide solution to the copper chloride solution under magnetic stirring (200r / min) within 2 hours, add dropwise After completion, continue to stir the reaction for half an hour. Then put the beaker into an oven at 45°C after being sealed with plastic wrap, take it out after 4 hours of insulation, and centrifuge, wash the precipitate with ethanol three times, centrifuge, and dry the gained solid overnight in an oven at 50°C ( 12 hours), to obtain black massive nano-copp...

Embodiment 3

[0035] A preparation method for nano copper sulfide applied to tumor photothermal therapy, the specific steps are: take 5g of polyethylene glycol (average molecular weight 500), put 1.0g of copper chloride dihydrate into a 100mL beaker, add 50 mL of deionized water was stirred and dissolved to obtain a copper chloride solution. Take by weighing 12g sodium sulfide nonahydrate and dissolve it in 200mL of deionized water to obtain an aqueous solution of sodium sulfide, use a peristaltic pump to add 30mL of sodium sulfide solution to the copper chloride solution under magnetic stirring (200r / min) within 2.5 hours, add dropwise After completion, continue to stir the reaction for half an hour. Then put the beaker into an oven at 45°C after being sealed with plastic wrap, take it out after 4 hours of insulation, and centrifuge, wash the precipitate with ethanol three times, centrifuge, and dry the gained solid overnight in an oven at 50°C ( 12 hours), obtain black massive nano-coppe...

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Abstract

The invention provides a preparation method of nano copper sulfide applied to the tumor photo-thermal therapy. The method is characterized by comprising the following steps: step 1, dissolving copperchloride dihydrate and polyethylene glycol in deionized water to obtain a copper chloride solution; step 2, dissolving sodium sulfide nonahydrate in deionized water to obtain a sodium sulfide aqueoussolution; step 3, adding the sodium sulfide aqueous solution into the copper chloride solution by using a peristaltic pump under magnetic stirring, and performing continuous stirring for 20-40 min after the dropping addition is completed; and placing the stirred solution in an oven, performing sealing and heat preservation, performing taking out, performing separation, washing the obtained precipitate with ethanol, and performing drying to obtain the nano copper sulfide particles. The photo-thermal effect of the nano copper sulfide particles is excellent.

Description

technical field [0001] The invention relates to the fields of nanomaterials and photothermal conversion, in particular to a method for preparing nanometer copper sulfide applied to photothermal therapy of tumors. Background technique [0002] Copper sulfide is an inorganic mineral that exists in nature. It is dark brown and is one of the most insoluble substances. In recent years, scientists have discovered that copper sulfide nanocrystals (nano-semiconductor materials) have very good near-red absorption, catalytic and antibacterial functions. Thus began the use of copper sulfide nanocrystals in tumor therapy. The joint research by the Institute of Physics and Chemistry of the Chinese Academy of Sciences, the University of California, Los Angeles and the Italian Institute of Technology found that copper sulfide nanocrystals have dual effects of photothermal and photodynamic. Compared with the traditional photothermal treatment of gold nanoparticles, copper sulfide nanocrys...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01G3/12A61K41/00A61P35/00B82Y40/00
CPCA61K41/0052A61P35/00B82Y40/00C01G3/12C01P2002/72C01P2004/64
Inventor 单晓茜秦玉杰韩宇靳行高颖
Owner SHANGHAI INST OF TECH
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