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Preparation method and applications of click chemistry based lincomycin molecularly imprinted composite membrane

A lincomycin and click chemistry technology, applied in chemical instruments and methods, other chemical processes, membranes, etc., can solve the problems of reduced thermal stability requirements of basement membranes, long preparation time of molecularly imprinted membranes, and shortened preparation time, etc. Achieve the effect of improving the selective separation efficiency, improving toughness and anti-pollution performance, and shortening the polymerization reaction time.

Active Publication Date: 2019-09-03
JIANGSU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In view of the deficiencies in the above-mentioned prior art, the purpose of the present invention is to overcome the technical defects in the prior art, solve the problems of long preparation time, high temperature, and low selectivity of traditional molecularly imprinted membranes, and make the thermal stability of the basement membrane The requirements are greatly reduced, the preparation time is greatly shortened, and the selective separation efficiency of the target molecule (lincomycin) is greatly improved

Method used

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  • Preparation method and applications of click chemistry based lincomycin molecularly imprinted composite membrane
  • Preparation method and applications of click chemistry based lincomycin molecularly imprinted composite membrane
  • Preparation method and applications of click chemistry based lincomycin molecularly imprinted composite membrane

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Experimental program
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Effect test

Embodiment 1

[0054] S1. Preparation of PVDF blank membrane:

[0055] Dissolve 3g of PVDF powder in 25ml of organic solvent N-methylpyrrolidone, stir and mix at 50°C for 12 hours to obtain a casting solution, let it stand for 24 hours, obtain a PVDF film through phase inversion and dry it in the air;

[0056] Preparation of S2, PVDF hydrophilic modified membrane:

[0057] 0.1211g tris(hydroxymethyl)aminomethane hydrochloride, 0.4g polyethyleneimine and 0.2g dopamine hydrochloride are dissolved in 100ml water to obtain a mixed solution, and the pH of the solution is adjusted to 8.5 with hydrochloric acid and sodium hydroxide, and the basement membrane Immerse in the mixed solution, shake at room temperature for 6 hours, wash and dry to obtain PVDF hydrophilic modified membrane;

[0058] Preparation of S3, KH570 modified PVDF hydrophilic membrane:

[0059] Disperse the PVDF hydrophilic modified membrane prepared in S2 in a mixed solution containing 80mL ethanol and 20mL water, then add 1ml ...

Embodiment 2

[0069] S1. Preparation of PVDF blank membrane:

[0070] Dissolve 4g of PVDF powder in 25ml of organic solvent N-methylpyrrolidone, stir and mix at 50°C for 24 hours to obtain a casting solution, let it stand for 24 hours, obtain a PVDF film through phase inversion and dry it in the air;

[0071] Preparation of S2, PVDF hydrophilic modified membrane:

[0072] 0.1211g tris(hydroxymethyl)aminomethane hydrochloride, 0.5g polyethyleneimine and 0.2g dopamine hydrochloride are dissolved in 100ml water to obtain a mixed solution, and the pH of the solution is adjusted to 8.5 with hydrochloric acid and sodium hydroxide, and the basement membrane Immerse in the mixed solution, shake at room temperature for 12 hours, wash and dry to obtain PVDF hydrophilic modified membrane;

[0073] Preparation of S3, KH570 modified PVDF hydrophilic membrane:

[0074] Disperse the PVDF hydrophilically modified membrane prepared in S2 in a mixed solution containing 80mL ethanol and 20mL water, then add...

Embodiment 3

[0085] S1. Preparation of PVDF blank membrane:

[0086] Dissolve 5g of PVDF powder in 25ml of organic solvent N-methylpyrrolidone, stir and mix at 50°C for 36 hours to obtain a casting solution, let it stand for 24 hours, obtain a PVDF film through phase inversion and dry it in the air;

[0087] Preparation of S2, PVDF hydrophilic modified membrane:

[0088] 0.1211g tris(hydroxymethyl)aminomethane hydrochloride, 0.6g polyethyleneimine and 0.2g dopamine hydrochloride are dissolved in 100ml water to obtain a mixed solution, and the pH value of the solution is adjusted to 8.5 with hydrochloric acid and sodium hydroxide, and the basement membrane Immerse in the mixed solution, shake at room temperature for 24 hours, wash and dry to obtain PVDF hydrophilic modified membrane;

[0089] Preparation of S3, KH570 modified PVDF hydrophilic membrane:

[0090] Disperse the PVDF hydrophilically modified membrane prepared in S2 in a mixed solution containing 80mL ethanol and 20mL water, th...

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Abstract

The invention belongs to the technical field of functional material preparation, and more specifically relates to a preparation method and applications of click chemistry based lincomycin molecularlyimprinted composite membrane. The preparation method comprises following steps: dopamine and polyethyleneimine are taken as hydrophilic modification materials, Lincomycin is taken as template molecule, 4-vinylpyridine is taken as a functional monomer, Pentaerythritol Tetra(3-mercaptopropionate) is taken as a crosslinking agent, Dipentaerythritol penta- / hexa-acrylate is taken as an auxiliary crosslinking agent, based on click chemistry polymerization method, the lincomycin molecule composite film is prepared. The prepared click chemistry based lincomycin molecularly imprinted composite membraneis capable of solving problems in the prior art that recycling of conventional lincomycin molecule imprinting polymer is difficult, and secondary pollution is easily caused; and in addition, the click chemistry based lincomycin molecularly imprinted composite membrane possesses excellent specific recognition capacity and adsorption separation capacity on Lincomycin.

Description

technical field [0001] The invention belongs to the technical field of preparation of functional materials, and specifically relates to a preparation method and application background technology of a click chemical imprinted lincomycin molecular composite film Background technique [0002] Lincomycin is a lincosamine-type alkaline antibiotic produced by Streptomyces, which has strong antibacterial activity against Gram-positive bacteria, anaerobic bacteria and some actinomycetes. As a veterinary drug, it is often used to prevent and treat porcine diarrhea, mycoplasma pneumonia in pigs, chronic respiratory diseases in chickens and other infections, and it can also promote the growth of chickens. However, its toxic and side effects are relatively strong, and the side effects are strong for sensitive people, which can cause abdominal or gastric cramps, vomiting, diarrhea, and even pseudomembranous enteritis and other gastrointestinal reactions. my country's "Maximum Residues o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D67/00B01D69/02B01D71/34B01J20/26B01J20/30
CPCB01D67/0006B01D69/02B01D71/34B01D2325/36B01J20/268
Inventor 董泽清卢健秦莹莹于超吴易霖孟敏佳李春香闫永胜笪祖林
Owner JIANGSU UNIV
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