Microbubble synergistic dynamic experiment system based on double frequency superimposed ultrasonic pulse in viscoelastic medium and microbubble synergistic dynamic experiment method based on double frequency superimposed ultrasonic pulse in viscoelastic medium

An ultrasonic pulse and experimental system technology, applied in the field of ultrasound, can solve the problems of insufficient cavitation activity, non-linear effect of excitation waveform, inaccurate parameter setting of thermal ablation and tissue damage, etc. Effect

Active Publication Date: 2019-09-17
XI AN JIAOTONG UNIV
View PDF9 Cites 6 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The existing methods of thermal ablation and tissue damage still have the following defects: Biological tissue is a kind of compressible fluid with viscoelasticity, and there are theoretical deficiencies in the development of HIFU process guided by the microbubble model in RPNNP incompressible fluid. There is no viscoelastic model in compressible fluid for simulation to guide the HIFU process, and the previous excitation waveform did not consider the nonlinear effect, resulting in inaccurate setting of thermal ablation and tissue damage parameters, and the cavitation activity in the focal area in single-frequency mode is not intense enough , so that the cavitation threshold is too high, the required peak sound pressure is too high, and the volume of the single focus is only a few mm 3

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Microbubble synergistic dynamic experiment system based on double frequency superimposed ultrasonic pulse in viscoelastic medium and microbubble synergistic dynamic experiment method based on double frequency superimposed ultrasonic pulse in viscoelastic medium
  • Microbubble synergistic dynamic experiment system based on double frequency superimposed ultrasonic pulse in viscoelastic medium and microbubble synergistic dynamic experiment method based on double frequency superimposed ultrasonic pulse in viscoelastic medium
  • Microbubble synergistic dynamic experiment system based on double frequency superimposed ultrasonic pulse in viscoelastic medium and microbubble synergistic dynamic experiment method based on double frequency superimposed ultrasonic pulse in viscoelastic medium

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0098] 1) Prepare a bovine serum albumin (BSA) polyacrylamide gel imitation with a mass fraction of 7%, and add bovine serum albumin as a temperature change indicator. The density of the gel phantom is 1.06g / cm 3 , the speed of sound in the finished gel phantom is 1477±5m / s, and the sound attenuation coefficient is 0.42±0.01dB / cm.

[0099] 2) the annular HIFU transducer 5, and the B-ultrasound probe etc. such as figure 1 Place and fix as shown, inject an appropriate amount of degassed water into the reaction vessel, and open the thermostat 7 . Turn on the ultrasound imaging device, and adjust the point to be damaged in the gel phantom to the focal point of the transducer according to the image guidance.

[0100] 3) According to Figure 11 Write the signal waveform to be generated by the arbitrary waveform generator.

[0101] 4) The timing of the signal excitation module and the monitoring and guiding module is controlled by the computer 10, so that the damage and monitorin...

Embodiment 2

[0105] 1) Prepare acrylamide mimic body fluid. Select fresh pig kidneys, cut them into a size of 5mm×3mm×30mm, fix them in simulated body fluid, and solidify them at room temperature.

[0106] 2) the annular array HIFU transducer 5, and the B-ultrasound probe etc. such as figure 1 To fix, inject an appropriate amount of degassed water into the reaction vessel, and open the thermostat 7. Turn on the ultrasound imaging equipment, and adjust the center position of the pig kidney to the focal point of the transducer according to the image guidance.

[0107] 3) According to Figure 11 Program the signal to be generated by the arbitrary waveform generator. The sound power was set to 240W throughout the process.

[0108] 4) Connect channel 1 of the arbitrary waveform generator in the synchronous signal control system to the ultrasonic excitation system, and channel 2 to the guidance monitoring system. Turn on each device and manually trigger the synchronization signal control sy...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses a microbubble synergistic dynamic experiment system based on a double frequency superimposed ultrasonic pulse in a viscoelastic medium and a microbubble synergistic dynamic experiment method based on the double frequency superimposed ultrasonic pulse in the viscoelastic medium. The experiment method comprises the following steps 1) according to an actual waveform of a focal region sound field measured by a hydrophone, setting KZK equation parameters and establishing a microbubble nonlinear excitation waveform; 2) constructing a HIFU synergistic model according to viscoelasticity of a biological tissue and vibration characteristics of the microbubble in compressible fluid; 3) establishing a microbubble synergistic dynamic method based on double frequency superimposition; 4) in combination with simulation results of steps above, determining a HIFU waveform phase, sound pressure and frequency parameters to perform a thermal ablation or tissue damage experiment. According to the system and the method provided by the invention, the dynamic characteristics of the microbubble in the biological tissue are used fully to design the sound wave waveform and the phase parameter, maximum vibration of the microbubble is triggered at a focal region, a cavitation effect is enhanced, and safety and efficiency of HIFU thermal ablation and tissue damage are improved.

Description

technical field [0001] The invention belongs to the field of ultrasonic technology, and in particular relates to a microbubble synergistic dynamics experiment system and method in a viscoelastic medium. Background technique [0002] High Intensity Focused Ultrasound (HIFU) has become a hot spot in the field of therapeutic ultrasound due to its non-invasive and strong focusing characteristics. At present, there are two mechanisms of action of high-intensity focused ultrasound: thermal ablation mechanism and tissue damage mechanism. The traditional HIFU thermal ablation mode mainly uses the thermal effect of ultrasound. The high-intensity ultrasound energy focused from the outside to the target area ablates the tissue locally, causing coagulation necrosis of the target tissue due to the instantaneous high temperature; the tissue damage (Histotripsy) mode mainly uses The cavitation mechanical effect of HIFU shatters the target tissue into micron-sized fragments. [0003] The ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): G01H9/00G06F17/50G09B23/28
CPCG01H9/002G01H9/004G09B23/28G06F30/20
Inventor 陆明珠刘邺晖李瑞昕刘妍杉李玉娇王轩耿一喆万明习
Owner XI AN JIAOTONG UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap