Process for high-temperature-resistant enteric coating for micro-dropping pills

A technology of enteric coating and high temperature resistance, applied in the field of biomedicine, can solve the problems of poor heat resistance and easy occurrence of adhesion, and achieve the effects of good heat resistance, simple coating method and good stability

Active Publication Date: 2019-09-20
ZHEJIANG WECOME MEDICINE IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the heat resistance of the enteric-coated Chansu pellet premix is ​​poor, and adhesion occurs easily at higher temperatures.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] A high-temperature-resistant enteric coating process for micro-droplet pills, the high-temperature-resistant enteric coating comprises the composition of the following parts by weight: 52 parts of methacrylic acid copolymer, hydroxypropyl methylcellulose succinic acid acetate 13 parts, 5 parts of silicone elastomer, 3 parts of triethyl citrate, 4 parts of nano silicon dioxide.

[0024] The content of modified methacrylic acid in the methacrylic acid copolymer is 37%.

[0025] The modified methacrylic acid is luteolin-modified methacrylic acid, and its preparation method is: adding methacrylic acid to toluene, the volume ratio of the methacrylic acid to toluene is 1:5, adding triethylamine , drop into thionyl chloride, then methacryloyl chloride was obtained after reflux reaction at 55°C for 4h, the molar ratio of triethylamine, methacrylic acid and thionyl chloride was 0.2:1:1.2; the luteolin Add in DMF, the mass volume ratio of luteolin and DMF is 1g:8mL, add sodium h...

Embodiment 2

[0030] A high-temperature-resistant enteric coating process for micro-droplet pills, the high-temperature-resistant enteric coating comprises the composition of the following parts by weight: 50 parts of methacrylic acid copolymer, hydroxypropyl methylcellulose succinic acid acetate 15 parts, 7 parts of silicone elastomer, 1 part of triethyl citrate, 4 parts of nano silicon dioxide.

[0031] The content of modified methacrylic acid in the methacrylic acid copolymer is 35%.

[0032] The modified methacrylic acid is luteolin-modified methacrylic acid, and its preparation method is: adding methacrylic acid to toluene, the volume ratio of the methacrylic acid to toluene is 1:4, adding triethylamine , drop into thionyl chloride, and then methacryloyl chloride was obtained after reflux reaction at 60°C for 3h, the molar ratio of triethylamine, methacrylic acid and thionyl chloride was 0.3:1:1.5; the luteolin Add in DMF, the mass volume ratio of luteolin and DMF is 1g:10mL, add sodi...

Embodiment 3

[0037] A high-temperature-resistant enteric coating process for micro-droplet pills, the high-temperature-resistant enteric coating comprises the composition of the following parts by weight: 55 parts of methacrylic acid copolymer, hydroxypropyl methylcellulose succinic acid acetate 10 parts, 5 parts of silicone elastomer, 2 parts of triethyl citrate, 5 parts of nano silicon dioxide.

[0038] The content of modified methacrylic acid in the methacrylic acid copolymer is 40%.

[0039] The modified methacrylic acid is luteolin-modified methacrylic acid, and its preparation method is: adding methacrylic acid to toluene, the volume ratio of the methacrylic acid to toluene is 1:7, adding triethylamine , drop into thionyl chloride, and then methacryloyl chloride was obtained after reflux reaction at 55°C for 4h, the molar ratio of triethylamine, methacrylic acid and thionyl chloride was 0.3:1:1.2; the luteolin Add in DMF, the mass volume ratio of luteolin and DMF is 1g:8mL, add sodi...

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Abstract

The invention relates to the biomedical technical field, and discloses a process for a high-temperature-resistant enteric coating for micro-dropping pills. The high-temperature-resistant enteric coating comprises the following components in parts by weight: 50-55 parts of a methacrylic acid copolymer, 10-15 parts of hydroxypropyl methyl cellulose succinate, 3-7 parts of a silicone elastomer, 1-5 parts of triethyl citrate and 3-5 parts of nanosilicon dioxide. The high-temperature-resistant enteric coating has good stability and heat resistance in a gastric acid environment and high drug release efficiency in an intestinal fluid environment. The process for the high-temperature-resistant enteric coating for the micro-dropping pills is convenient to operate, and the prepared dropping pill preparation has smooth surface, bacterial resistance and no adhesion and is convenient to store and transport.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a high-temperature-resistant enteric-coating process for micro-droplet pills. Background technique [0002] The enteric coating is a coating that prevents the drug from disintegrating or dissolving within 2 hours in the artificial gastric juice at 37°C, and disintegrates or dissolves in the artificial intestinal juice within 1 hour, and releases the drug, which can prevent the drug from being destroyed in the stomach and The irritation of the drug to the stomach, etc. At present, problems such as sticking pills to the inner wall of the guide barrel, long coating cycle, and poor disintegration are prone to occur when enteric coating is carried out on the mainstay. [0003] The Chinese patent application number is CN201510231542.4, which discloses an enteric-coated Chansu pellet premix and a preparation method thereof. The toad venom pellet premix is ​​composed of a drug-load...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/50A61K47/32A61K47/38A61K47/34A61K47/04A61K47/14A61K47/22
CPCA61K9/501A61K9/5015A61K9/5026A61K9/5031A61K9/5042
Inventor 纪晓燕华杰沈汉福魏凯丁京伟
Owner ZHEJIANG WECOME MEDICINE IND
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