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Multipurpose photon cold-set gel and preparation method thereof

A cold gel, multi-purpose technology, applied in the fields of medical cosmetology and biomedicine, can solve the problems of low transmittance of photon cold gel, damage to the probe, insufficient moisturizing type, etc., to achieve uniform texture, strong adhesion, easy to use The effect of applying to the skin

Active Publication Date: 2019-09-27
王月玲 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, photonic cold gels generally have disadvantages such as low light transmittance, weak thermal conductivity, insufficient moisturizing type, not easy to remove, and damage to the probe. Therefore, the use of photonic cold gels in the field of injection beauty technology has a large market demand and economical considerable benefits

Method used

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  • Multipurpose photon cold-set gel and preparation method thereof
  • Multipurpose photon cold-set gel and preparation method thereof
  • Multipurpose photon cold-set gel and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0051] To 20L mass concentration of 0.2% polyvinyl alcohol 1788 (low viscosity type) aqueous solution, add 6L mass concentration of 2% polylactide (intrinsic viscosity is 0.4dl / g) dichloromethane solution, stir for 3 hours, The stirring speed is 350rpm, and the mixture in the reactor is released. Suction filtration, vacuum drying, ready for filling.

[0052] Mix 0.1 part of carbomer, 1 part of polyethylene glycol and 1 part of glycerin, stir evenly, add 50 parts of water for injection, stir, after completely swelling, add 0.5 part of ethyl p-hydroxybenzoate, 0.1 part of triethanolamine, and then Add the remaining water for injection, continue to stir for 1 hour, add 5 parts of PLGA microspheres, continue to stir for 2 hours, and obtain.

Embodiment 2

[0054] To 10L mass concentration of 0.5% polyvinyl alcohol 1788 (low viscosity type) aqueous solution, add mass concentration of 10L5% polylactide (intrinsic viscosity is 1.0dl / g) chloroform solution, stir for 8 hours, stirring speed 500rpm , release the mixture in the reactor. Suction filtration, vacuum drying, ready for filling.

[0055] Mix 5 parts of carbomer, 10 parts of polyethylene glycol and 5 parts of mannitol, stir evenly, add 50 parts of water for injection, stir, after swelling completely, add the remaining water for injection, adjust with hydrochloric acid solution or sodium hydroxide solution When the pH reaches 6.8, after stirring for 1 hour, add 15 parts of PLGA microspheres and continue stirring for 2 hours to obtain the product.

Embodiment 3

[0057] To 20L mass concentration is 1.0% polyvinyl alcohol 1788 (low viscosity type) aqueous solution, add 15L mass concentration as 10% polylactide (intrinsic viscosity is 2.0dl / g) ethyl acetate solution, stir 15 hours, The stirring speed is 650rpm, and the mixture in the reaction kettle is released; it is filtered, vacuum-dried, and prepared for filling.

[0058] Mix 1.5 parts of carbomer, 5 parts of polyethylene glycol and 5 parts of glycerin, stir evenly, add 50 parts of water for injection, stir, after completely swelling, add 0.3 parts of ethyl p-hydroxybenzoate, 0.5 parts of triethanolamine, and then Add the remaining water for injection, continue to stir for 1 hour, then add 30 parts of PLGA microspheres, continue to stir for 2 hours to obtain the product.

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Abstract

The invention relates to a multipurpose photon cold-set gel and a preparation method thereof, and belongs to the technical fields of medical cosmetology and biomedical treatment. The multipurpose photon cold-set gel provided by the invention mainly comprises the following ingredients in parts by weight on the basis of 100 parts of the ingredients: 2-50 parts of PLGA (poly(lactic-co-glycolic acid)), 0.1-5 parts of carbomer, 1-10 parts of polyethylene glycol, 1-10 parts of an osmotic pressure regulator, 0.1-2 parts of a pH regulator, 0.05-0.5 parts of a bacteriostatic agent and the balance of water for injection. The multipurpose photon cold-set gel prepared in the invention can be used as a coating agent for laser cosmetology, can also be used for injection cosmetology, is good in biocompatibility and does not have cytotoxicity, skin irritation, sensitization and the like; in addition, the preparation method is easy in operation, so that industrial production is conveniently realized.

Description

technical field [0001] The invention belongs to the technical fields of medical cosmetology and biomedicine, and in particular relates to a multipurpose photonic cold gel and a preparation method thereof. Background technique [0002] With the improvement of today's material living standards, more and more people will pay more attention to their quality of life and the pursuit of beauty, which makes my country's cosmetic surgery industry will gradually enter a stage of rapid development. It has become a common phenomenon to correct soft tissue defects and repair aging and wrinkled skin through plastic surgery technology, so as to maintain the perfect and youthful facial shape. [0003] Among various plastic surgery techniques, injection beauty technology accounts for the largest proportion, accounting for about 40% of the entire beauty market. Injection beauty technology is a beauty technology that partially modifies the human body through injection to achieve exquisite loc...

Claims

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Application Information

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IPC IPC(8): A61L27/18A61L27/16A61L27/50A61L27/52A61L27/58A61K41/00
CPCA61L27/18A61L27/16A61L27/52A61L27/50A61L27/58A61K41/00A61L2400/06C08L67/04C08L33/02
Inventor 王月玲
Owner 王月玲