Preparation method of antibacterial silver-doped hydroxyapatite microspheres

A hydroxyapatite and silver doped technology, applied in the fields of botanical equipment and methods, chemical instruments and methods, phosphorus compounds, etc., can solve the problems of low utilization rate, waste of empty shells, etc., and achieve added value and good crystallinity. , good biocompatibility

Pending Publication Date: 2019-10-18
SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The present invention is dedicated to solving the problems of a large number of discarded empty shells and low utilization rate of shellfish aquatic products after processing, and provides a method for preparing antibacterial silver-doped hydroxyapatite microspheres with shells as the main calcium source. Simple operation, wide source of raw materials, low cost and easy promotion

Method used

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  • Preparation method of antibacterial silver-doped hydroxyapatite microspheres
  • Preparation method of antibacterial silver-doped hydroxyapatite microspheres
  • Preparation method of antibacterial silver-doped hydroxyapatite microspheres

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] 1) The washed and dried oyster shells are crushed, ground, and screened with a 200-mesh filter to obtain oyster shell powder;

[0038] 2) Take 0.45g of oyster shell powder (Ca 2+ 0.0045mol), use 30ml of 10 vol.% acetic acid solution to dissolve, keep stirring until no bubbles are generated, then centrifuge at 4°C and 9000rpm for 5min, and take the supernatant;

[0039] 3) Dilute the supernatant to 50ml with deionized water, and add 50ml of phosphoric acid solution (0.06M) dropwise at a rate of 1ml / min under continuous stirring;

[0040] 4) After the phosphoric acid solution is added dropwise, add 0.2352g of sodium citrate and 0.085g of silver nitrate (Ag + 0.0005mol) and 6g of urea, and continued to stir for 0.5h to obtain a clear precursor reaction solution;

[0041] 5) Transfer the precursor reaction liquid obtained in step 4) to the reaction kettle, put it in an oven, and conduct a hydrothermal reaction at 90°C for 48 hours;

[0042] 6) After the reaction, take i...

Embodiment 2

[0044] 1) The washed and dried mussel shells are crushed, ground, and screened with a 200-mesh filter to obtain mussel shell powder;

[0045] 2) Take mussel shell powder 0.4g (Ca 2+ 0.004mol), use 20ml of 10 vol.% acetic acid solution to dissolve, keep stirring until no bubbles are generated, then centrifuge at 4°C and 9000rpm for 5min, and take the supernatant;

[0046] 3) Dilute the supernatant to 50ml with deionized water, and add 50ml of phosphoric acid solution (0.06M) dropwise at a rate of 1ml / min under continuous stirring;

[0047] 4) After the phosphoric acid solution is added dropwise, add 0.2352g of sodium citrate and 0.169g of silver nitrate (Ag + 0.001mol) and 6g of urea, and continued to stir for 0.5h to obtain a clear precursor reaction solution;

[0048] 5) Transfer the precursor reaction solution obtained in step 4) to the reaction kettle, put it in an oven, and conduct a hydrothermal reaction at 90°C for 36 hours;

[0049] 6) After the reaction, take it out ...

Embodiment 3

[0051] 1) Crush the washed and dried abalone shells, grind them, and screen them with a 200-mesh filter to obtain abalone shell powder;

[0052] 2) Take 0.3g of abalone shell powder (Ca 2+ 0.003mol), use 10ml of 10 vol.% acetic acid solution to dissolve, keep stirring until no bubbles are generated, then centrifuge at 4°C and 9000rpm for 5min, and take the supernatant;

[0053] 3) Dilute the supernatant to 50ml with deionized water, and add 50ml of phosphoric acid solution (0.06M) dropwise at a rate of 1ml / min under continuous stirring;

[0054] 4) After the phosphoric acid solution is added dropwise, add 0.2352g of sodium citrate and 0.338g of silver nitrate (Ag + 0.002mol) and 6g of urea, and continued to stir for 0.5h to obtain a clear precursor reaction solution;

[0055] 5) Transfer the precursor reaction liquid obtained in step 4) to the reaction kettle, put it in an oven, and conduct a hydrothermal reaction at 90°C for 48 hours;

[0056] 6) After the reaction, take ...

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Abstract

The invention discloses a preparation method of antibacterial silver-doped hydroxyapatite microspheres. The method utilizes shells as a main raw material and a hydrothermal synthesis technique combined with a chelation templating agent to prepare the antibacterial silver-doped hydroxyapatite microspheres. The preparation method provided by the invention is simple, has wide sources of raw materialsand low costs, and is easy to promote; and each obtained microsphere has a good spherical structure, a size of 10 [mu]m, good antibacterial property and a long-lasting bacteriostatic effect, and is expected to be an effective filling restoration material for bones and teeth.

Description

technical field [0001] The invention belongs to the field of material preparation and biomedicine, and in particular relates to a preparation method of antibacterial silver-doped hydroxyapatite microspheres. Background technique [0002] As the main inorganic component of hard parts such as teeth and bones in mammals, hydroxyapatite (Ca l0 (P0 4 ) 6 (OH) 2 , HAP) are widely used in the field of bone tissue engineering due to their excellent biocompatibility, osteoconductivity, bioactivity and ability to directly combine with host bone tissue. However, with the deepening of its research and application, pure hydroxyapatite has been difficult to meet the requirements in some aspects, such as antibacterial properties. Although hydroxyapatite is the most osteoconductive and biocompatible material among other calcium phosphates, its antibacterial properties are limited, and bacterial infection is the main cause of implant failure, so antibacterial treatment of hydroxyapatite ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01B25/32A01N59/16A01N25/08A01N25/34A01P1/00A61K47/02A61L27/12A61L27/54A61L27/02
CPCC01B25/325A01N59/16A01N25/08A01N25/34A61K47/02A61L27/12A61L27/54A61L27/025C01P2004/32C01P2004/61A61L2300/104A61L2300/404A61L2430/02
Inventor 陈景帝黄浩
Owner SHANDONG UNIV
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