Plant composition for treating hyperuricemia and gout and plant composition solid granules

A technology of hyperuricemia and composition, which is applied in the fields of food and medicine, can solve problems such as injury, increased risk of stroke, hypersensitivity allergic syndrome, etc., achieves reduction of serum uric acid and urinary uric acid levels, prolonged action time, Immunity-boosting effect

Inactive Publication Date: 2019-11-08
JF PHARMALAND TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] 1. High uric acid increases the risk of hypertension in the Asian population by 57%, increases the risk of total death by 8%, and increases the risk of death from cardiovascular disease by 21%.
[0005] 2. High uric acid increases the risk of coronary heart disease by 9%, and increases the risk of death from coronary heart disease by 16%.
[0006] 3. High uric acid increases the risk of renal function reduction by 21%, and increases the risk of death due to chronic kidney disease by 68%.
[0007] 4. High uric acid increases the risk of stroke by 47%, and increases the risk of stroke death by 26%.
[0010] At present, the treatment of hyperuricemia and gout is mainly based on chemical drugs. For example, allopurinol is a xanthine oxidase inhibitor widely used in clinical practice. It can inhibit the production of uric acid by inhibiting xanthine oxidase, but it may cause Toxic side effects such as liver damage and hypersensitivity allergic syndrome

Method used

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  • Plant composition for treating hyperuricemia and gout and plant composition solid granules
  • Plant composition for treating hyperuricemia and gout and plant composition solid granules

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Effect test

Embodiment 1

[0045] A method for preparing solid particles of a plant composition, by mass percentage, the plant composition, auxiliary materials, isomalt, flavoring agent and essence are mixed uniformly, a 50wt% ethanol aqueous solution is used to prepare a soft material, and an 18-mesh sieve is used to prepare a soft material. Net granulation, drying at 50°C for 4.5 hours to obtain solid particles of plant composition, wherein, in parts by mass, the ratio of plant composition, auxiliary material, isomalt, flavoring agent and essence is 45:35:20: 0.3:0.1, the auxiliary materials are pregelatinized starch and resistant dextrin, and the ratio of pregelatinized starch and resistant dextrin is 15:20 in parts by mass. In parts by mass, the plant composition consists of 1 part of celery seed extract, 1 part of corn silk powder, 1 part of pumpkin powder, 1 part of lotus leaf powder, 1 part of mulberry powder, and 1 part of ginseng powder Mixed with 1 part of grape powder.

Embodiment 2

[0047]A method for preparing solid particles of a plant composition, by mass percentage, the plant composition, auxiliary materials, isomalt, flavoring agent and essence are mixed uniformly, a 60wt% ethanol aqueous solution is used to prepare a soft material, and an 18-mesh sieve is used to prepare a soft material. Net granulation, drying at 50°C for 4 hours to obtain solid particles of plant composition, wherein, in parts by mass, the ratio of plant composition, auxiliary material, isomalt, flavoring agent and essence is 50:40:10: 0.3:0.1, the excipients are sorbitol and resistant dextrin, and the ratio of sorbitol and resistant dextrin is 25:15 in parts by mass. In parts by mass, the plant composition consists of 3 parts of celery seed extract, 5 parts of corn silk powder, 5 parts of pumpkin powder, 5 parts of lotus leaf powder, 3 parts of mulberry powder, and 3 parts of ginseng powder Mixed with 5 parts of grape powder.

Embodiment 3

[0049] A method for preparing solid particles of a plant composition, by mass percentage, the plant composition, auxiliary materials, isomalt, flavoring agent and essence are mixed uniformly, a 75wt% ethanol aqueous solution is used to prepare a soft material, and an 18-mesh sieve is used to prepare a soft material. Net granulation, drying at 45°C for 3 hours to obtain solid particles of plant composition, wherein, in parts by mass, the ratio of plant composition, auxiliary material, isomalt, flavoring agent and essence is 60:30:10: 0.3:0.1, the auxiliary materials are sorbitol and microcrystalline cellulose, and the ratio of sorbitol and microcrystalline cellulose is 20:10 in parts by mass. In parts by mass, the plant composition consists of 10 parts of celery seed extract, 10 parts of corn silk powder, 10 parts of pumpkin powder, 10 parts of lotus leaf powder, 10 parts of mulberry powder, and 10 parts of ginseng powder Mixed with 12 parts of grape powder.

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Abstract

The invention discloses a plant composition for treating hyperuricemia and gout and plant composition solid granules. The plant composition is prepared from celery seed extract, corn silk powder, pumpkin powder, lotus leaf powder, mulberry powder, ginseng powder grape powder by mixing. The plant composition solid granules are mainly prepared from the plant composition. According to the plant composition for treating the hyperuricemia and the gout and the plant composition solid granules, the celery seed extract, the corn silk powder, the pumpkin powder, the lotus leaf powder, the mulberry powder, the ginseng powder and the grape powder are compounded for use to improve the nutritional compositions, and the celery seed extract can significantly reduce the serum uric acid level and the urineuric acid level of the hyperuricemia; the corn silk powder and the lotus leaf powder can accelerate urinary excretion and help uric acid excretion; and the pumpkin powder, the mulberry powder, the ginseng powder and the grape powder have the functions of nourishing the liver and kidney, enhancing immunity and protecting the liver and kidney. The action mechanism of each component is different, multi-component mixing effectively exerts the synergistic effect between the components, the action time is prolonged, the curative effect is enhanced, and the components are homologous to medicine andfood, are safe and have no side effects.

Description

technical field [0001] The invention belongs to the technical field of food and medicine, and specifically relates to a plant composition and solid particles of the plant composition for treating hyperuricemia and gout. Background technique [0002] Hyperuricemia (HUA) is defined as hyperuricemia when fasting blood uric acid levels are higher than 420 μmol / L in men and 360 μmol / L in women on two different days under a normal purine diet. [0003] Uric acid is the terminal metabolite of human purine compounds. Disorders of purine metabolism lead to hyperuricemia. The prevalence of this disease is affected by many factors, which are related to heredity, gender, age, lifestyle, dietary habits, drug treatment and economic development. According to reports on the prevalence of hyperuricemia in various places in recent years, there are currently about 120 million people with hyperuricemia in my country, accounting for about 10% of the total population. trend. [0004] 1. High u...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/899A61K9/16A61P19/06A23L33/00
CPCA23V2002/00A61K9/1652A61K36/23A61K36/258A61K36/42A61K36/605A61K36/62A61K36/87A61K36/899A23L33/00A61P19/06A61K2300/00A23V2200/30A23V2250/21
Inventor 张殿杭魏洪君吕建营
Owner JF PHARMALAND TECH DEV
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