Preparation method of 4-propythio-2-nitroaniline

A technology of nitroaniline and o-nitroaniline, which is applied in the field of preparation of 4-propylthio-2-nitroaniline, can solve the problems of affecting the economic benefits of industrial production, poor industrialization feasibility, complicated operation steps, etc. Low, easy to purify, simple production process
CN110498752AActive Publication Date: 2019-11-26SHANDONG GUOBANG PHARMA +1
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Applications(China)
Current Assignee / Owner
SHANDONG GUOBANG PHARMA
Publication Date
2019-11-26

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Abstract

The invention discloses a preparation method of 4-propythio-2-nitroaniline, and solves the technical problems of unreasonable preparation method, high raw material price, high toxicity, complex operation, high cost, large production of three wastes, low yield and unsuitability for industrial production in the prior art. The preparation method of 4-propythio-2-nitroaniline provided by the inventiontakes o-nitroaniline, disulfur dichloride and chloropropane as the raw materials, and carries out condensation reaction and alkylation reaction in order under the action of a catalyst so as to obtain4-propythio-2-nitroaniline. The method can be widely applied technical field of synthesis of albendazole.
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Description

technical field

[0001] The invention belongs to the technical field of albendazole synthesis, in particular to a preparation method of 4-propylthio-2-nitroaniline. Background technique

[0002] Albendazole was developed by Smith Kline Bichem Company (predecessor of GlaxoSmithKline). It is a broad-spectrum thiabendazole anthelmintic drug, which can be used for humans and animals, and can inhibit the growth of parasites. Growth and reproduction, by inhibiting the intestinal tract of worms or absorbing protein in cells, resulting in the inability of worms to take in sugar for survival, depleting the endogenous glycogen of worms, inhibiting the fumarate reductase system, and preventing the production of adenosine triphosphate , so that the worms cannot survive and reproduce, and eventually the worms gradually die due to energy exhaustion. Albendazole has the effect of completely killing hookworm eggs and whipworm eggs and partially killing roundworm eggs, and can also kill and ...

Claims

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