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Articular cartilage repair stent and preparation method and application thereof

A articular cartilage and bone technology, applied in joint implants, joint implants, bone implants, etc., can solve the problems of hyaline cartilage flatness, elastic modulus, and hardness need to be further improved, so as to maintain mechanical properties. , large quantity, good flatness effect

Pending Publication Date: 2019-12-03
BEIJING WANJIE MEDICAL DEVICE CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

When drilling microfracture is used together with existing scaffold materials to treat articular cartilage damage, compared with only drilling microfracture, hyaline cartilage can be generated to overcome the problem of fibrocartilage, but the hyaline cartilage is smooth. degree, modulus of elasticity, and hardness need to be further improved

Method used

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  • Articular cartilage repair stent and preparation method and application thereof
  • Articular cartilage repair stent and preparation method and application thereof
  • Articular cartilage repair stent and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] Embodiment 1, the preparation of articular cartilage repair support

[0056] Such as figure 1 Shown, a kind of articular cartilage repair bracket, it comprises from bottom to top:

[0057] cancellous bone 1;

[0058] first cortical bone 2;

[0059] And, combined with the first platelet-rich plasma gel layer 3 on the upper surface of the first cortical bone 2;

[0060] Wherein: the cancellous bone 1 and the first cortical bone 2 are incompletely decalcified bones.

[0061] Articular cartilage repair scaffold in the present invention treats articular cartilage defect, wherein: cortical bone provides mechanical properties, such as: mechanical stress and elastic modulus, which solves the defects of poor mechanical mechanics of natural biomaterial scaffolds such as silk, fibrin, and human amniotic membrane; The loose porous structure of cancellous bone can recruit and accommodate more bone marrow and bone marrow-derived stem cells released from subchondral bone (such as...

Embodiment 2

[0076] Embodiment 2, the application effect of articular cartilage repair support

[0077] 1) Human bone marrow mesenchymal stem cells (BMSCs) were planted on the articular cartilage repair scaffold prepared in Example 1, and the adhesion, proliferation and secretion of cartilage extracellular matrix of the cells on the scaffold were investigated. The result is as image 3 as shown, image 3 The middle left picture shows the DNA content of human bone marrow mesenchymal stem cells after planting human bone marrow mesenchymal stem cells on the articular cartilage repair scaffold for different days, which can reflect the adhesion and proliferation ability of human bone marrow mesenchymal stem cells on the scaffold. The detection method is PicoGreen fluorescent staining method (PicoGreen double-stranded DNA fluorescence quantitative assay kit, Shanghai Haling Biotechnology Co., Ltd.). image 3 The middle right picture shows the content of glycosaminoglycans secreted by chondrocy...

Embodiment 3

[0084] Embodiment 3, the mechanical performance test of articular cartilage repair scaffold itself

[0085] For the articular cartilage repair scaffold prepared in Example 1, the scaffold material perforated on the articular cartilage repair scaffold prepared in Example 1 (punching is performed between the decalcification step and the cleaning step, the specific method is: perpendicular to The horizontal surface of decalcified cortical bone is laser-drilled with a diameter of 0.1mm, and the distance between the centers of adjacent small holes is 0.5mm. Elastic modulus and hardness were tested. The detection method is the same as the corresponding method in Example 2, but the sample size is different, being 20 (long) * 20 (wide) * 10mm (thick), the obtained results are shown in the table below,

[0086]

[0087]

[0088] Conclusion: In the two test directions of length and thickness, the elastic modulus of the perforated scaffold material and the non-perforated scaffold ...

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Abstract

The invention relates to an articular cartilage repair stent and a preparation method and application thereof. The articular cartilage repair stent comprises, from bottom to top: cancellous bone; a first cortical bone; and a first platelet-rich plasma gel layer, the first platelet-rich plasma gel layer is bonded to an upper surface of the first cortical bone, and the cancellous bone and the firstcortical bone are incompletely decalcified bone. When the articular cartilage repair stent is matched with a microfracture to repair articular cartilage defects, the microfracture provides seed cells,the cancellous bone and the first cortical bone are used as stent materials, the first platelet-rich plasma gel provides growth factors, the resulting new cartilage is hyaline cartilage rather than fibrous cartilage, the new hyaline cartilage is large in number and high in elastic modulus and hardness, and the repair area is complete and has good flatness.

Description

technical field [0001] The invention relates to the field of medical devices, in particular to a scaffold for repairing articular cartilage, a preparation method and application thereof. Background technique [0002] Articular cartilage belongs to hyaline cartilage, which covers the surface of joints and plays an important role in buffering stress, absorbing shocks, lubricating joint surfaces, and preventing wear and tear. Human articular cartilage is an avascular tissue without blood supply. Its nutrition comes from the moisture of the surrounding joint synovial fluid. Once damaged, it is difficult to regenerate. Therefore, cartilage repair has become one of the most challenging clinical problems for orthopedic surgeons. According to the survey results of the Institute of Sports Medicine of Peking University, cartilage damage accounts for more than 40.5% of knee sports injuries, and cartilage damage is often accompanied by joint swelling and pain. There are various causes ...

Claims

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Application Information

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IPC IPC(8): A61F2/30
CPCA61F2/30756A61F2002/30761A61F2310/00359A61F2240/002A61F2002/2835A61F2002/2817
Inventor 张梅陈书香孙雪莲史丰田董喜华胡荣荣杨洁王爱敏孙宇航
Owner BEIJING WANJIE MEDICAL DEVICE CO LTD
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