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Polyvinyl imidazole terpolymer based on amphoteric ionization and its preparation method and application

A technology of polyvinylimidazole terpolymer and zwitterion, which is applied in the field of polyvinylimidazole terpolymer and its preparation, can solve the problem of poor improvement of substrate surface hydrophobicity, increase of production cost and Material loss, surface energy increase and other issues, to achieve good antibacterial activity and anti-protein adhesion performance, simple and controllable preparation process, excellent antibacterial effect

Inactive Publication Date: 2021-05-07
EAST CHINA UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are three problems in grafting zwitterionic polymers whose side chains contain ester bonds or amide bonds to the surface of the substrate: (1) the hydrophobicity of the substrate surface cannot be improved, and in some low surface energy After the surface of the substrate is grafted with zwitterionic polymers, the contact angle is greatly reduced and the surface energy is increased; (2) the choice of the substrate varies with the application, which greatly increases the production cost and material loss; (3) the surface of the substrate The grafted zwitterionic polymer will undergo hydrolysis, exfoliating functional groups such as anionic and cationic groups, resulting in the loss of antimicrobial properties on the surface of the substrate
The above problems severely limit the application of this type of zwitterionic polymer in the field of antibacterial films

Method used

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  • Polyvinyl imidazole terpolymer based on amphoteric ionization and its preparation method and application
  • Polyvinyl imidazole terpolymer based on amphoteric ionization and its preparation method and application
  • Polyvinyl imidazole terpolymer based on amphoteric ionization and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] Synthesis of Polyvinylimidazole Terpolymer P(VIm 75 -co-HPMA 10 -co-BA 15 )

[0056] In an anhydrous, argon-protected environment, vinylimidazole Vim (6.79ml), hydroxypropyl methacrylate HPMA (1.70ml) and butyl acrylate BA (2.16ml) were sequentially added to a 100ml three-necked polymerization bottle, Under the condition of heating in an oil bath, the dropwise addition is completed at a temperature of 65°C, mechanically stirred for 0.5h, and again anhydrous and filled with argon, repeated three times, and slowly added dropwise to the polymerization bottle through a constant pressure dropping funnel Anhydrous ethanol solution 16ml, the process of adding is carried out under the protection of argon, stir evenly, vacuumize and fill with argon again (open the air duct connecting the polymerization bottle to the water pump, turn on the vacuum pump of the water pump, and immediately after opening Rotate the piston of the polymerization bottle, pump for about 2-3 minutes, p...

Embodiment 2

[0067] Synthesis of amphoteric ionized polyvinylimidazole terpolymer P(VIm-CH 2 CH 2 SO 3 Na + )Br - -co-PHPMA-co-PBA

[0068] Under the protection of inert protective gas (argon), take 0.1g polyvinylimidazole terpolymer P(VIm 75 -co-HPMA 10 -co-BA 15 ) was dissolved in 8ml of N,N-dimethylformamide under the protection of nitrogen, and after being completely dissolved, under the protection of argon, a mass of polyvinylimidazole terpolymer P(VIm 75 -co-HPMA 10 -co-BA 15 ) three times the amount of 2-bromoethanesulfonic acid sodium salt (SBES) 0.3g, heated in an oil bath to 105°C for 18h, and after the reaction was completed, precipitated with 100ml of glacial ether to obtain a yellow solid, which was placed in a vacuum oven Medium-vacuum drying 24h, obtains based on the amphoteric ionized polyvinylimidazole terpolymer P(VIm-CH 2 CH 2 SO 3 Na + )Br - -co-PHPMA-co-PBA.

[0069] x:y:z=75:10:15.

[0070]

Embodiment 3

[0072] Synthesis of PVCIB-co-PHPMA-co-PBA Based on Zwitterionized Polyvinylimidazole Terpolymer PVCIB-co-PHPMA-co-PBA

[0073] Weigh 0.4g polyvinylimidazole terpolymer P(VIm 75 -co-HPMA 10 -co-BA 15 ) was dissolved in 1ml N,N-dimethylformamide to prepare P(VIm with a concentration of 0.4g / ml 75 -co-HPMA 10 -co-BA 15 ) solution, pour it on a tetrafluoroethylene plate, seal it and place it in a constant temperature drying oven at 40°C to form a film naturally for 24 hours, take out the film and place it on a new tetrafluoroethylene plate, rinse it with deionized water three times , drop 500 μl of 3-bromopropionic acid methanol solution with a concentration of 1.2g / ml, seal it and place it in a constant temperature drying oven at 50°C for 48 hours of reaction. After the reaction is complete, take out the membrane and wash it with deionized water. The solvents and reactants were stored in deionized water at a temperature of 4 °C to obtain PVCIB-co-PHPMA-co-PBA based on amphot...

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Abstract

The invention discloses a polyvinyl imidazole terpolymer based on amphoteric ionization, the structure of which is as follows: the amphoteric ionization based polyvinyl imidazole terpolymer prepared by the present invention has a simple and controllable preparation process, and is easy to A polymer with a specific molecular weight and a predetermined composition structure is obtained, which has good antibacterial activity and anti-protein adhesion performance, and is suitable for the modification of biomedical antibacterial materials.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and relates to a series of amphoteric ionization-based polyvinylimidazole terpolymers and a preparation method and application thereof. Background technique [0002] As a typical organic antibacterial finishing agent, quaternary ammonium compound has been put into use for more than 50 years. It is a cationic surfactant, which is often used as a disinfectant and preservative, and is widely used in surface cleaning, hospital disinfection, etc. each field. The antibacterial properties of quaternary ammonium salt compounds are greatly affected by the number of cationic quaternary ammonium salts in the molecule and the length of the alkyl group. The antibacterial mechanism of quaternary ammonium salts is: the quaternary ammonium salt group is positively charged, and the bacterial cell membrane itself is negatively charged, and the two are combined by electrostatic attraction, which distu...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F226/06C08F220/20C08F220/18C08F8/44A01N43/50A01P1/00C08J7/12C08J7/14C08J5/18C08L39/04
CPCA01N43/50C08F8/44C08F226/06C08J5/18C08J7/12C08J7/14C08J2339/04
Inventor 郎美东尹晓源
Owner EAST CHINA UNIV OF SCI & TECH