Preparation method of composite nanofibrous membrane loaded with nanozyme and its wound dressing

Abstract

The invention discloses a method for preparing a nano-enzyme-loaded composite nanofiber membrane and a wound dressing. The method for preparing the nano-enzyme-loaded composite nanofiber membrane comprises the steps that (1) 0.1-0.5 part, by weight, of a nanoenzyme is dissolved in 100 parts, by weight, of an aqueous solution of polyvinyl alcohol-acrylamide grafted copolymer with the mass fractionof 5-15% to prepare a spinning solution; (2) the prepared spinning solution is spun into a nanofiber membrane by using an electrostatic spinning method; and (3) and the prepared nanofiber membrane iscross-linked at a temperature of 120 DEG C-150 DEG C for 15-30 min to obtain the nano-enzyme-loaded composite nanofiber membrane. According to the method for preparing the nano-enzyme-loaded compositenanofiber membrane and the wound dressing, the formation of wound crusta can be prevented, newly generated granulation tissue is prevented from sticking, and pain during dressing change is avoided; and the fibrin and necrotic tissue are conveniently dissolved, and the number of changing is reduced; a hypoxic environment is created, and capillary formation is promoted; the release of a variety ofgrowth factors is promoted, and activity is exerted; and wound pain is relieved, and scar formation is reduced.

Description

technical field [0001] The invention relates to a preparation method of a composite nanofiber membrane loaded with nanozyme and a wound dressing thereof, belonging to the technical field of synthetic fibers. Background technique [0002] Surgery, trauma, burns, dermatitis, etc. will all lead to skin damage and defects. Drugs and dressings are often used clinically for skin wound care. Traditional dressings are generally made of cotton, burlap or linen. The problems of this type of dressing are: the wound surface cannot be kept moist, and the dry environment tends to form scabs on the wound surface, which forces epidermal cells to migrate around the scab The dressing fiber is easy to fall off, which is easy to cause foreign body reaction and affects wound healing; the shielding effect of the dressing is poor after being soaked, and pathogens can easily reach the wound through the dressing, causing exogenous infection; the wound granulation tissue is easy to grow into the mesh...

AI Technical Summary

Problems solved by technology

Traditional dressings are generally made of cotton, burlap or linen. The problems of this type of dressing are: the wound surface cannot be kept moist, and the dry environment tends to form scabs on the wound surface, which forces epidermal cells to migrate around the scab The dressing fiber is easy to fall off, which is easy to cause foreign body reaction and affects wound healing; the shielding effect of the dressing is poor after being soaked, and pathogens can easily reach the wound through the dressing, causing exogenous infection; the wound granulation tissue is easy to grow into the mesh of the dressing In the eyes, the wound surface adheres to the dressing, which damages the new granulation tissue and causes pain when changing the dressing; it is inconvenient to use, and the workload of changing the dressing is heavy, etc.

[0003] In order to solve the above problems of traditional dressings, people have developed new dressings. Most of these new dressings form a closed microenvironment on the wound surface to isolate external bacterial infection and absorb wound exudate. Although it solves the problem of absorbing wound exudate , keep the wound surface dry, protect the wound surface from external bacterial infection and other issues, but it is only a simple physical protection, and cannot solve the problem of slow wound healing

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